Qhov sib txawv tseem ceeb ntawm cov kua qaub phosphatase thiab alkaline phosphatase yog cov kua qaub phosphatase yog ib qho phosphatase enzyme uas ua haujlwm zoo nyob rau hauv acidic pH, thaum alkaline phosphatase yog ib qho phosphatase enzyme uas ua haujlwm zoo hauv alkaline pH.
Phosphatase yog cov enzyme uas catalyzes hydrolysis ntawm phosphoric esters (phosphoric acid monoester). Cov tshuaj tiv thaiv no liberates ib qho inorganic phosphate thiab cawv. Phosphatase yog ib qho subcategory ntawm hydrolases. Nws yog ib qho tseem ceeb heev rau kev ua haujlwm lom neeg xws li kev tswj hwm cellular thiab teeb liab. Vim yog qhov nthuav dav ntawm phosphatase hauv kev tswj hwm ntawm tes, nws yog thaj chaw txaus siab rau kev tshawb fawb tshuaj. Phosphatase yog cais raws li qhov tshwj xeeb ntawm cov substrate, cov kab ke homology, thiab kev ua haujlwm zoo. Acid phosphatase thiab alkaline phosphatase yog ob phosphatase enzymes.
YAcid Phosphatase yog dab tsi?
Acid phosphatase yog ib qho phosphatase enzyme uas ua haujlwm zoo hauv acidic pH. Nws yog ib qho enzyme siv los tso cov phosphoryl pawg los ntawm cov molecules thaum lub sij hawm zom mov. Nws tseem tuaj yeem raug cais ntxiv raws li phosphomonoesterase. Acid phosphatase yog khaws cia hauv lysosomes. Acid phosphatase ua haujlwm thaum lysosomes fuse nrog endosomes. Qhov no yog vim lysosomes thiab endosomes yog acidified thaum lawv ua haujlwm. Ib puag ncig acidic tseem ceeb heev rau kev ua haujlwm ntawm cov kua qaub phosphatase enzyme.
Daim duab 01: Acid Phosphatase
Acid phosphatase muaj nyob hauv ntau hom tsiaj thiab nroj tsuag. Hauv tib neeg, ntau hom kua qaub phosphatase muaj nyob hauv cov kabmob sib txawv. Lawv cov qib ntshav qab zib yog siv los ntsuas qhov ua tiav ntawm kev phais kho mob qog noj ntshav prostate. Acid phosphatase kuj tau siv yav dhau los los kuaj mob qog noj ntshav prostate. Tsis tas li ntawd, nws kuj tseem siv los ua tus cim cytogenetic los sib txawv ntawm ob kab mob ntawm cov kab mob qog ntshav qog ntshav qog ntshav (TXL): B-ALL thiab T-ALL.
Cov kab mob hauv av siv cov kua qaub phosphatase kom tau txais cov organic phosphate as-ham. Qee cov cag ntoo tso tawm carboxylates uas ua haujlwm ntawm phosphatase. Yog li ntawd, cov enzyme no pab cov nroj tsuag kom mob phosphorous hauv cov av tsis muaj zaub mov. Ntxiv mus, Norcardia cov kab mob ua kom cov kua qaub phosphatase enzyme thiab siv nws ua cov pa roj carbon.
Alkaline Phosphatase yog dab tsi?
Alkaline phosphatase yog ib qho phosphatase enzyme uas ua haujlwm zoo hauv pH alkaline. Nws yog homodimeric protein enzyme ntawm 86 kDa. Txhua monomer muaj tsib cysteine residues, ob lub zinc atoms, thiab ib tug magnesium atom, uas yog ib qho tseem ceeb heev rau lub catalytic muaj nuj nqi ntawm alkaline phosphatase. Nws muaj peev xwm dephosphorylate compounds. Cov enzyme no muaj nyob rau hauv ob qho tib si prokaryotes thiab eukaryotes. Txawm li cas los xij, muaj cov qauv sib txawv nyob ntawm ib puag ncig cov kab mob no nyob hauv.
Daim duab 02: Alkaline Phosphatase
Hauv tib neeg, nws ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv lub siab thiab kev loj hlob hauv lub cev pob txha. Yog li ntawd, nws cov concentration hauv cov hlab ntsha tuaj yeem siv los ua biomarker los kuaj xyuas kab mob siab thiab osteomalacia. Qhov txawv txav ntawm alkaline phosphatase kuj tseem tuaj yeem qhia txog cov teeb meem ntsig txog lub siab, lub zais zis, lossis pob txha. Ntxiv mus, cov xwm txheej xws li mob raum, kab mob thiab kev noj zaub mov tsis zoo kuj tau pom qhov txawv txav ntawm alkaline phosphatase hauv cov ntshav. Qib Alkaline phosphatase hauv cov ntshav yog txiav txim siab los ntawm kev kuaj ALP.
Dab tsi zoo sib xws ntawm Acid Phosphatase thiab Alkaline Phosphatase?
- Acid phosphatase thiab alkaline phosphatase yog ob hom phosphatase enzymes.
- Ob leeg yog cov proteins ua los ntawm cov amino acids.
- Lawv yog hydrolases.
- Ob leeg muaj kev ua haujlwm ntawm dephosphorylating compounds.
- Lawv muaj nyob hauv prokaryotes thiab eukaryotes.
Qhov txawv ntawm Acid Phosphatase thiab Alkaline Phosphatase yog dab tsi?
Acid phosphatase yog ib qho phosphatase enzyme uas ua haujlwm zoo hauv acidic pH, thaum alkaline phosphatase yog ib qho phosphatase enzyme uas ua haujlwm zoo hauv pH alkaline. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm acid phosphatase thiab alkaline phosphatase. Tsis tas li ntawd, acid phosphatase yog 35 kDa protein, thaum alkaline phosphatase yog 86 kDa protein.
Cov hauv qab no infographic teev qhov sib txawv ntawm cov kua qaub phosphatase thiab alkaline phosphatase hauv daim ntawv tabular rau ib sab sib piv.
Summary – Acid Phosphatase vs Alkaline Phosphatase
Phosphatase enzyme hydrolyzes phosphoric acid monoester rau hauv phosphate ion thiab cawv. Acid phosphatase thiab alkaline phosphatase yog ob hom phosphatase enzymes. Acid phosphatase ua haujlwm zoo hauv acidic pH, thaum alkaline phosphatase ua haujlwm zoo hauv alkaline pH. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm acid phosphatase thiab alkaline phosphatase.
