Qhov sib txawv tseem ceeb ntawm carbimazole thiab methimazole yog tias carbimazole yog ib hom tshuaj tsis muaj zog, hos methimazole yog ib hom tshuaj nquag.
Carbimazole thiab methimazole yog cov tshuaj tseem ceeb heev uas siv los kho cov mob ntsig txog cov thyroid caj pas. Thaum peb noj cov tshuaj carbimazole rau kev kho mob hypothyroidism, nws hloov mus rau hauv nws daim ntawv methimazole hauv lub cev.
YCarbimazole yog dab tsi?
Carbimazole yog ib qho tshuaj uas muaj txiaj ntsig zoo hauv kev kho mob hyperthyroidism. Tom qab nqus tau, cov tshuaj no tau hloov mus rau hauv daim ntawv nquag (uas yog vim li cas nws tau muab faib ua ib qho prodrug). Cov tshuaj nquag ntawm carbimazole yog methimazole. Daim ntawv nquag no, methimazole, tuaj yeem tiv thaiv thyroid peroxidase enzyme los ntawm iodinating thiab coupling cov tyrosine residues ntawm thyroglobulin. Yog li, nws tuaj yeem txo qhov tsim cov thyroid hormones hu ua T3 thiab T4 (thyroxine). Cov tshuaj no yog los ntawm World He alth Organization's List of Essential Medicines.
Daim duab 01: Carbimazole
Hyperthyroidism yog ib yam mob tshwm sim los ntawm kev tsim cov thyroid ntau ntau los ntawm cov thyroid caj pas. Kev kho mob rau tus mob no feem ntau muaj xws li titrating koob tshuaj carbimazole kom txog rau thaum peb tuaj yeem soj ntsuam cov mob euthyroid hauv tus neeg mob lossis tswj cov koob tshuaj carbimazole siab rau kev tawm tsam ntawm endogenous thyroid ntau lawm, tom qab ntawd hloov cov thyroid hormone nrog levothyroxine. Cov txheej txheem no yog hu ua "block thiab hloov" mechanism. Feem ntau, qhov kev kho no yog ua tau li ntawm 18-24 lub hlis.
Txawm li cas los xij, tuaj yeem muaj qee qhov kev mob tshwm sim thiab. Tej yam tshwm sim yog pob khaus thiab pruritus. Peb tuaj yeem kho cov mob no siv cov tshuaj tiv thaiv kab mob thaum noj carbimazole tsis tu ncua. Ntxiv mus, rau cov neeg mob rhiab heev, peb tuaj yeem siv propylthiouracil los hloov.
Methimazole yog dab tsi?
Methimazole lossis thiamazole yog cov tshuaj muaj txiaj ntsig zoo hauv kev kho mob hyperthyroidism. Nws tuaj yeem kho tus kab mob Graves, toxic multinodular goiter, thiab thyrotoxic teebmeem. Nws muaj txoj kev hais lus ntawm kev tswj hwm. Qhov siab tshaj plaws tuaj yeem tau txais tom qab ib lub lim tiam ntawm kev tswj hwm.
Txawm li cas los xij, tuaj yeem muaj qee qhov kev mob tshwm sim ntawm kev siv cov tshuaj no, uas suav nrog khaus, plaub hau poob, xeev siab, mob leeg, o, thiab mob plab. Nws tuaj yeem muaj qee qhov kev mob tshwm sim loj heev, suav nrog cov qe ntshav qis, daim siab tsis ua haujlwm, thiab vasculitis. Yog li ntawd, nws tsis pom zoo kom siv thaum thawj peb lub hlis twg ntawm cev xeeb tub. Tab sis yog tias tsis tuaj yeem zam tau, peb tuaj yeem siv nws hauv peb lub hlis thib ob ntawm cev xeeb tub lossis tom qab, nrog rau thaum pub niam mis.
Daim duab 02: Methimazole
Lub bioavailability ntawm methimazole yog li 93%. Nws cov protein khi yog qhov tsis txaus ntseeg, thiab cov metabolism hauv cov tshuaj tshwm sim hauv daim siab. Tsis tas li ntawd, kev tshem tawm ib nrab-lub neej yog li 5-6 teev, thiab qhov tso tawm tshwm sim hauv lub raum. Cov tshuaj formula ntawm no methimazole yog C4H6N2S, thiab molar mass yog hais txog 114.17 g / mol. Lub melting point yog hais txog 146 degrees Celsius, thiab nws yog me ntsis soluble nyob rau hauv dej.
Thaum xav txog cov txheej txheem ntawm kev ua ntawm methimazole, nws tuaj yeem cuam tshuam cov enzyme thyroperoxidase uas tuaj yeem ua rau cov thyroid hormone synthesis ntawm oxidizing anion iodide rau iodine, hypoiodous acid, thiab enzyme-txuas hypoiodate. Qhov no pab txhawb qhov sib ntxiv ntawm tyrosine residues rau cov tshuaj hormone precursor thyroglobulin. Nws yog ib qho tseem ceeb cov kauj ruam nyob rau hauv lub synthesis ntawm triiodothyronine thiab thyroxine.
Qhov txawv ntawm Carbimazole thiab Methimazole yog dab tsi?
Carbimazole thiab methimazole yog cov tshuaj tseem ceeb heev uas siv los kho cov mob ntsig txog cov thyroid caj pas. Qhov sib txawv tseem ceeb ntawm carbimazole thiab methimazole yog carbimazole yog ib hom tshuaj uas tsis muaj zog, hos methimazole yog ib hom tshuaj nquag.
Cov hauv qab no qhia txog qhov sib txawv ntawm carbimazole thiab methimazole hauv daim ntawv tabular rau kev sib piv ntawm ib sab.
Summary – Carbimazole vs Methimazole
Carbimazole yog ib qho tshuaj uas muaj txiaj ntsig zoo hauv kev kho mob hyperthyroidism. Methimazole los yog thiamazole yog ib yam tshuaj pab kho mob hyperthyroidism. Qhov sib txawv tseem ceeb ntawm carbimazole thiab methimazole yog carbimazole yog ib hom tshuaj uas tsis muaj zog, hos methimazole yog ib hom tshuaj nquag.
