Qhov Tseem Ceeb Qhov Sib Txawv - Kab Mob Cycle Cycle vs Cov Cycle Cell Raws Li
Lub voj voog ntawm tes yog cov xwm txheej uas tshwm sim hauv lub xovtooj, ua rau nws faib thiab sib npaug ntawm DNA thiaj li tsim tau cov ntxhais tshiab. Lub voj voog ntawm tes tuaj yeem pom hauv ob qho tib si kab mob thiab eukaryotes. Hauv cov kab mob, lub voj voog ntawm tes muaj peb theem (B, C, thiab D). "B" theem yog hais txog kev faib cell, "C" theem yog txheeb xyuas DNA replication theem, thiab nyob rau hauv lub "D" theem, lub cell muab faib ua ob tug ntxhais hlwb. Raws li nyob rau hauv eukaryotes, lub voj voog ntawm tes rov muab faib ua peb theem. Lub interphase (G1, G2, thiab S), mitotic theem (M) thiab cytokinesis. Thaum lub sij hawm interphase, lub cell loj hlob los ntawm accumulating cov as-ham xws li proteins thiab duplicates nws DNA. Nyob rau hauv lub interphase, lub cell tab tom npaj rau nws faib. Thaum lub sij hawm mitotic theem, cov chromosomes cais. Hauv cytokinesis, chromosomes thiab cytoplasm cais ua ob lub hlwb tshiab. Qhov no yog lub voj voog ntawm tes. Txhawm rau kom muaj kev faib kom raug, lub xov tooj ntawm tes muaj cov txheej txheem hu ua cell checkpoints (G1 checkpoint, G2 / M checkpoint, thiab Metaphase checkpoint). Qhov chaw kuaj xyuas qhov ua tsis tiav feem ntau ua rau muaj kev hloov pauv uas nws tsim cov qog nqaij hlav qog nqaij hlav nrog kev faib ntau dhau. Qhov sib txawv tseem ceeb ntawm Cancer Cell Cycle thiab Normal Cell Cycle yog tias lub voj voog ntawm cov qog nqaij hlav qog nqaij hlav muaj cov hlwb ntawm cov cell faib tsis tau, ntawm qhov tsis sib xws, cov hlwb hauv lub voj voog ntawm tes muaj peev xwm tswj tau ntawm tes..
Cancer Cell Cycle yog dab tsi?
Hauv kev faib cell, nws yog qhov tseem ceeb tshaj plaws kom muaj kev tswj hwm txhawm rau ua kom tiav cov cell faib kom raug. Cov chaw kuaj xyuas ntawm tes tau koom nrog cov txheej txheem no hauv lub voj voog ntawm tes raws li lawv tsis tu ncua tswj DNA puas, rov ua yuam kev (G1 / S thiab G2 / M checkpoints) thiab kho spindle fiber txuas rau tus muam chromatids (Metaphase checkpoint). Yog tias qhov kev puas tsuaj tsis tuaj yeem kho tau, lub xov tooj ntawm tes yuav raug programmed cell tuag lossis apoptosis.
Daim duab 01: Kev Loj Hlob Cancer
Lub xovtooj ntawm qhov chaw kuaj xyuas tsis ua haujlwm ua rau muaj kev hloov pauv kom qhib tau thiab yog li hloov lub sijhawm ib txwm ntawm kev faib cell. Qhov no yog lub npe hu ua kab mob qog noj ntshav. Ib qho piv txwv nto moo yog tias Tp53 proto-oncogene thiab qog nqaij hlav qog nqaij hlav uas ntes lub voj voog ntawm tes ntawm G1 qhov chaw kuaj xyuas yog tias nws tau kuaj pom muaj kev puas tsuaj DNA. Tab sis DNA kev hloov pauv hloov qhov tshwj xeeb proto-oncogene rau hauv oncogene qhov twg nws yuav tsis ntes lub voj voog ntawm tes txawm tias nws pom DNA puas. Qhov xwm txheej no ua rau muaj kev hloov pauv ntxiv hauv lwm cov noob muaj feem xyuam rau lub xov tooj ntawm tes taw qhia receptors (cell receptors) xws li "Ras" thiab "tyrosine kinase." Thaum kawg nws overexpresses lub xov tooj ntawm tes teeb liab receptors thiab cell signaling thiab li no ua rau ntau cell faib. Feem ntau, mob qog noj ntshav mis, mob qog noj ntshav thiab mob ntsws cancer yog tshwm sim los ntawm cov kab mob uas tau hais los saum no. Hauv cov kab mob qog noj ntshav ntawm cov kab mob qog noj ntshav yuav tshwm sim ua ntej soj ntsuam cov qog nqaij hlav cancer.
Lub voj voog ntawm tes yog dab tsi?
Hauv eukaryotes, lub voj voog ntawm tes ib txwm muab faib ua peb theem. Lub interphase (dua muab faib ua peb theem: G1, G2, thiab S), mitotic theem (M) thiab cytokinesis. Thaum lub sij hawm interphase, lub cell loj hlob, accumulating cov as-ham zoo li protein thiab duplicates nws DNA. Nyob rau hauv lub interphase, lub cell tab tom npaj rau nws faib. "G1" (Gap 1) theem ntawm interphase yog pab rau cov protein synthesis. Thaum nyob rau hauv "S" (Synthesis) theem DNA yog duplicated."G2" theem yog tsim los ntawm kev loj hlob ntawm tes los ntawm kev sib npaug ntawm cov organelles. Thaum lub sij hawm mitotic theem, cov chromosomes cais. Thiab thaum kawg, nyob rau theem cytokinesis, cov chromosomes thiab cytoplasm cais ua ob lub hlwb tshiab uas nws ua tiav ib lub voj voog ntawm tes.
Daim duab 02: Kev faib tawm ntawm lub cev thiab kev faib cov kabmob kheesxaws
Yuav kom muaj kev faib kom raug, lub xovtooj ntawm tes muaj cov txheej txheem hu ua cell checkpoints raws li tau hais hauv qab no.
- G1/S checkpoint- tswj thiab kho DNA puas thiab rov ua yuam kev.
- G2/M checkpoint- tswj DNA kev ncaj ncees thiab kho DNA puas.
- Metaphase checkpoint- tshuaj xyuas seb txhua tus viv ncaus chromatids puas raug xa mus rau spindle microtubules.
Yog li, cov chaw kuaj xyuas tseem ceeb heev. Thiab qhov ua tsis tiav feem ntau ua rau kev hloov pauv qhov twg nws tsim cov qog nqaij hlav qog noj ntshav nrog kev faib ntau dhau.
Dab tsi zoo sib xws ntawm Cancer Cell Cycle thiab Ib Cycle Cell Cycle?
- Cell division tshwm sim nyob rau hauv ob qho tib si txheej txheem.
- Cells ntau ntau hauv ob txoj kev.
- Kev loj hlob tshwm sim tuaj yeem pom nyob rau hauv ob qho tib si mob qog noj ntshav thiab lub voj voog ntawm tes.
Dab tsi yog qhov txawv ntawm Kab Mob Cycle Cycle thiab Lub Cycle Cell Li Cas?
Cancer Cell Cycle vs Normal Cell Cycle |
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| Cancer cell cycle yog ib lub voj voog ntawm tes uas cov hlwb faib tsis tau. | Lub voj voog ntawm tes li qub yog lub voj voog ntawm tes uas tswj kev faib cell. |
| Cell Communication | |
| Cov hlwb tsis sib txuas lus nrog lwm cov hlwb thaum lub sijhawm mob qog noj ntshav. | Cov hlwb sib txuas lus nrog cov neeg nyob sib ze thiab ua cov lus teb hauv lub voj voog ntawm tes. |
| Checkpoints | |
| Cov chaw kuaj xyuas tsis zoo, thiab cov chaw kuaj xyuas cov protein tau hloov pauv hauv lub voj voog qog nqaij hlav. | Cov chaw kuaj xyuas tswj lub voj voog ntawm tes raws li txoj hauv kev raug. |
| Cell Repair thiab Cell Death | |
| Cells tsis kho, thiab lawv tsis raug apoptosis thaum lub sij hawm mob qog noj ntshav. | Txhua lub xovtooj kho lossis raug mob ntawm tes apoptosis thaum lub voj voog ntawm tes. |
| Maturation (Differentiation) | |
| Cov hlwb hauv lub voj voog qog nqaij hlav cancer tsis paub tab (tsis txawv txav). | Cov hlwb yog matured nyob rau hauv ib txwm cell voj voog. |
| Cov qog nqaij hlav cancer tsis muaj qhov nplaum thiab yog li ntab mus. | Cov hlwb hauv lub voj voog ntawm tes ib txwm muaj cov nplaum nplaum thiab ua ke ua ke. |
| cuam tshuam rau lub cev tiv thaiv kab mob | |
| Cov hlwb hauv lub voj voog qog nqaij hlav cancer yog evading lub cev tiv thaiv kab mob. | Cov hlwb hauv lub voj voog ntawm tes thaum raug puas lawm lawv raug tshem tawm los ntawm lub cev tiv thaiv kab mob. |
| Angiogenesis | |
| Cov hlwb hauv lub voj voog qog nqaij hlav qog nqaij hlav tau txais kev kho mob angiogenesis txawm tias tsis tsim nyog. | Cov hlwb hauv lub voj voog ntawm tes ib txwm raug mob angiogenesis tsuas yog ib feem ntawm kev loj hlob ib txwm. |
| Muaj peev xwm Metastasize (Spread) | |
| Cov hlwb hauv lub voj voog qog nqaij hlav cancer metastasize. | Lub cev ib txwm khaws cia rau hauv ib qho chaw. |
Summary – Cancer Cell Cycle vs Normal Cell Cycle
Lub voj voog ntawm tes yog qhov xwm txheej uas tshwm sim hauv lub xov tooj ntawm tes, ua rau nws faib thiab sib npaug ntawm DNA txhawm rau tsim cov ntxhais tshiab. Lub voj voog ntawm tes tuaj yeem pom hauv ob qho tib si kab mob thiab eukaryotes. Vim muaj kev hloov pauv tas mus li, lub voj voog ntawm tes poob nws tuav los tswj kev faib tawm ntawm tes. Li no nws tshwm sim cov qog nqaij hlav cancer thiab kev loj hlob ntawm qog nqaij hlav. Qhov sib txawv tseem ceeb ntawm Cancer Cell Cycle thiab Normal Cell Cycle yog tias lub voj voog ntawm cov qog nqaij hlav qog nqaij hlav muaj cov hlwb ntawm cov cell faib tsis tau, piv txwv li, cov hlwb hauv lub voj voog ntawm tes muaj peev xwm tswj tau ntawm tes.
Download the PDF Version of Cancer Cell Cycle vs Normal Cell Cycle
Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov rub tawm PDF version ntawm no Qhov txawv Ntawm Kab Mob Cycle Cycle thiab Lub Cycle Cell Cycle
