Qhov txawv ntawm Kab Mob Kab Mob Kab Mob thiab Kab Mob Kab Mob Ntshav Qab Zib

2024 Tus sau: Alex Aldridge | [email protected]. Kawg hloov kho: 2023-12-17 13:40

Key Difference – Kab Mob Kab Mob Sib Kis vs Sickle Cell Anemia

Tus kab mob Sickle cell yog ib hom kab mob hemoglobinopathy tshwm sim los ntawm kev hloov pauv hauv beta globin uas txhawb nqa cov polymerization ntawm deoxygenated hemoglobin, ua rau cov cell liab distortion, hemolytic anemia, micro vascular obstruction thiab ischemic cov ntaub so ntswg puas. Sickle cell anemia yog ib hom kab mob loj heev ntawm cov ntshav liab uas tshwm sim los ntawm cov kab mob mob qog nqaij hlav uas hloov pauv ntawm hemoglobin cuam tshuam cov qe ntshav liab mus rau hauv cov duab crescent ntawm cov pa oxygen tsawg. Cov kab mob Sickle cell muaj ib pab pawg ntawm pathological tshwm sim thaum mob kab mob cell anemia yog ib qho kev tshwm sim ntawm cov kab mob kis kab mob. Qhov no yog qhov tseem ceeb ntawm qhov sib txawv ntawm cov kab mob mob qog nqaij hlav thiab mob qog nqaij hlav hauv hlwb.

Kab mob Sickle Cell yog dab tsi?

Tus kab mob Sickle cell yog ib hom kab mob hemoglobinopathy tshwm sim los ntawm kev hloov pauv hauv beta globin uas txhawb nqa polymerization ntawm deoxygenated hemoglobin ua rau cov cell liab distortion, hemolytic anemia, micro vascular obstruction thiab ischemic cov ntaub so ntswg puas.

Hemoglobin muaj cov qauv tetrameric uas yog tsim los ntawm ob khub ntawm alpha thiab beta chains. Cov neeg laus laus laus muaj HbA (α ₂ β_{2) raws li lawv daim ntawv tseem ceeb ntawm hemoglobin. Hauv kab mob mob qog noj ntshav, glutamate residue nyob rau hauv thib rau codon ntawm beta globin noob yog hloov los ntawm valin. Qhov kev hloov pauv no ua rau muaj ntau yam kev hloov pauv thiab kev ua haujlwm hauv hemoglobin molecule. Ntxiv nrog rau HbA, cov tib neeg uas raug mob los ntawm cov kab mob ntawm tes muaj ib yam tshwj xeeb ntawm hemoglobin hauv lawv cov hlwb liab hu ua sickle hemoglobin (HbS).}

Pathogenesis ntawm Sickle Cell Disease

Txias ntws cytosol ntawm cov qe ntshav liab hloov mus rau hauv cov kua nplaum nplaum thaum lub siab ib nrab ntawm cov pa oxygen poob qis dua qib tseem ceeb. Nrog txuas ntxiv deoxygenation, HbS molecules polymerize rau hauv cov fibers ntev hauv cov hlwb liab distorting lawv mus rau hauv cov duab crescent. Qhov no yog lub hauv paus pathological rau cov kev tshwm sim loj xws li mob hemolysis, micro vascular occlusion, thiab cov ntaub so ntswg puas.

Raws li HbS polymers loj hlob, lawv pib herniate los ntawm cov cell liab. Qhov kev hloov kho ntawm cov qe ntshav liab no ua rau muaj kev nkag mus ntawm Ca²⁺ +^{thiab dej. Kev rov ua dua ntawm cov txheej txheem no dehydrates cov qe ntshav liab, ua rau lawv nruj thiab ntom. Thaum kawg lawv dhau los ua cov kab mob uas tsis muaj mob uas tau tshem tawm sai sai ntawm kev ncig los ntawm cov hlab ntsha hemolysis.}

Muaj ntau qhov kev xav txog lub hauv paus pathological ntawm micro vascular occlusions, tab sis qhov tseeb mechanism tsis to taub meej.

Qhov Tseem Ceeb Qhov Sib Txawv - Kab Mob Kab Mob Sib Kis vs Sickle Cell Anemia

Daim duab 01: Kab mob Sickle cell yog los ntawm tus qauv autosomal recessive.

Tshuaj Kho Mob Ntawm Kab Mob Kab Mob

Tus kab mob Sickle cell muaj ntau qhov kev kuaj mob tshwm sim. Qee tus neeg raug cuam tshuam tuaj yeem ua rau tuag taus thaum qee tus tuaj yeem muaj cov tsos mob me me xwb.

(Ob leeg mob mob hlwb thiab mob mob qog noj ntshav muaj ntau yam kev kho mob tshwm sim uas tau tham nyob rau hauv nqe lus "kev kho mob ntawm cov kab mob ntshav qab zib")

Kev kuaj mob ntawm tus kab mob Sickle Cell

Hemoglobin electrophoresis kom pom tias muaj HbS
Dithionate test
Kev kuaj mob ua ntej yug menyuam yog ua tau los ntawm kev tshuaj xyuas ntawm tus menyuam hauv plab DNA tau los ntawm amniocentesis.

Sickle Cell Anemia yog dab tsi?

Cov kab mob loj heev ntawm cov ntshav liab uas tshwm sim los ntawm cov kab mob qog nqaij hlav uas cov kab mob hloov pauv ntawm hemoglobin cuam tshuam cov qe ntshav liab mus rau hauv cov duab crescent ntawm qis qis qis yog hu ua mob qog nqaij hlav.

(Pathogenesis ntawm sickle cell anemia tau tham nyob rau hauv nqe lus "pathogenesis ntawm sickle cell kab mob".)

Qhov txawv ntawm Sickle Cell Disease thiab Sickle Cell Anemia

Daim duab 02: Kabmob Cells

Tshuaj Kho Mob Ntawm Sickle Cell Anemia

Cov yam ntxwv kho mob yog qhov mob hnyav hemolytic anemia punctuated los ntawm kev kub ntxhov. Yuav muaj plaub hom kev kub ntxhov.

1. Vaso Occlusive Crises

Vaso occlusive kev kub ntxhov yog ntau dua li lwm tus thiab raug predisposed los ntawm yam xws li kab mob, acidosis, lub cev qhuav dej thiab deoxygenation. Vim yog qhov txhaws ntawm cov hlab ntsha, cov ntshav muab rau qee qhov chaw ntawm lub cev, tshwj xeeb tshaj yog rau cov extremities, raug cuam tshuam. Yog li ntawd, infarcts tshwm sim hauv cov cheeb tsam no, ua rau muaj kev mob hnyav. Muaj ib yam mob hu ua txhais tes taw syndrome qhov twg tus neeg mob yws ntawm qhov mob hnyav ntawm qhov kawg. Qhov no tshwm sim vim yog infarcts nyob rau hauv cov pob txha me me ntawm libs.

2. Visceral Sequestration Crises

Cov kev kub ntxhov no tshwm sim los ntawm qhov mob thiab cov ntshav ntim hauv lub cev. Anemia exacerbates mus rau theem hnyav thaum muaj teeb meem visceral sequestration. Mob hauv siab mob yog qhov teeb meem txaus ntshai tshaj plaws ntawm qhov teebmeem no. Cov neeg mob raug mob ntawm lub hauv siab thiab dyspnea. X-ray hauv siab yuav qhia pom muaj cov kab mob pulmonary infiltrates.

3. Aplastic Crises

Cov no tshwm sim tom qab kis tus kab mob parvo thiab qee zaum vim tias tsis muaj folate thiab. Aplastic crises yog tus cwj pwm los ntawm qhov poob ntawm hemoglobin tam sim ntawd feem ntau yuav tsum tau txhaj tshuaj.

4. Hemolytic Anemia Y

Lwm yam kev kho mob ntawm Sickle Cell Anemia

Ntshav pob txha hauv qis qis.
Spleen loj thaum me nyuam mos tab sis maj mam txo qhov loj vim yog infarcts (autosplenectomy).
Pulmonary hypertension.

Kev kuaj mob ntawm Sickle Cell Anemia

qib hemoglobin feem ntau yog 6-9g / dL.
Ntseeg cov mob mob thiab lub hom phiaj hauv cov ntshav zaj duab xis.
Kev tshuaj ntsuam xyuas mob rau cov tshuaj xws li dithionate yog qhov zoo thaum cov ntshav deoxygenated.
Hauv HPLC, HbSS raug kuaj pom raws li daim ntawv tseem ceeb ntawm hemoglobin thiab HbA tsis pom.

Kev Kho Mob Mob Mob Ntshav Qab Zib

Kev zam txim rau qhov paub tias ua rau muaj kev kub ntxhov.
khoom noj khoom haus zoo thiab huv.
YPneumococcal, Haemophilus thiab tshuaj tiv thaiv kab mob meningococcal.
Kev kub ntxhov yuav tsum tau kho raws li tus mob, hnub nyoog thiab kev ua raws li cov tshuaj ntawm tus neeg mob.

Dab tsi zoo sib xws ntawm Sickle Cell Disease thiab Sickle Cell Anemia?

Ob leeg mob mob hlwb thiab mob qog noj ntshav yog tshwm sim los ntawm tib yam kev hloov caj ces uas cuam tshuam rau beta globin chains thiab yog li cov qauv thiab kev ua haujlwm ntawm hemoglobin.
Vim mob mob ntshav qab zib mob ntshav qab zib yog ib qho kev tshwm sim ntawm cov kab mob mob qog nqaij hlav, lawv kuj qhia cov yam ntxwv kho mob.

Dab tsi yog qhov txawv ntawm Kab Mob Kab Mob Kab Mob thiab Kab Mob Ntshav Qab Zib?

Sickle Cell Disease vs Sickle Cell Anemia
Tus kab mob Sickle cell yog ib hom kab mob hemoglobinopathy tshwm sim los ntawm kev hloov pauv hauv beta-globin uas txhawb nqa cov polymerization ntawm deoxygenated hemoglobin, ua rau cov cell liab distortion, hemolytic anemia, micro vascular obstruction thiab ischemic cov ntaub so ntswg puas	Sickle cell anemia yog ib hom kab mob loj heev ntawm cov ntshav liab uas tshwm sim los ntawm cov kab mob mob qog nqaij hlav uas cov kab mob hloov pauv ntawm hemoglobin cuam tshuam cov qe ntshav liab mus rau hauv cov duab crescent ntawm cov pa oxygen tsawg.
Pathological tshwm sim
Tus kab mob Sickle cell muaj ntau yam kab mob tshwm sim.	Sickle cell anemia yog ib qho kev tshwm sim ntawm cov kab mob mob qog nqaij hlav.

Summary – Kab mob Cell VS Sickle Cell Anemia

Ob tus kab mob mob qog noj ntshav thiab mob qog nqaij hlav mob ntshav qab zib yog cov kab mob tshwm sim thiab kev kho kom raug tuaj yeem pab txhawb kev ua neej nyob ntawm tus neeg mob. Cov kab mob Sickle cell muaj ib pab pawg ntawm pathological tshwm sim thaum mob kab mob cell anemia yog ib qho kev tshwm sim ntawm cov kab mob kis kab mob. Qhov no yog qhov sib txawv tseem ceeb ntawm cov kab mob kis kab mob thiab mob qog nqaij hlav mob ntshav qab zib.

Download PDF Version of Sickle Cell Disease vs Sickle Cell Anemia

Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline hom phiaj raws li cov ntawv sau tseg. Thov download PDF version ntawm no Qhov txawv Ntawm Kab Mob Kab Mob thiab Kab Mob Kab Mob Sickle Cell Anemia.