Qhov sib txawv tseem ceeb ntawm p53 thiab TP53 yog p53 yog cov qog nqaij hlav protein uas tiv thaiv kev loj hlob ntawm cov qog thaum TP53 yog cov noob uas sau rau p53 qog nqaij hlav protein.
P53 thiab TP53 yog cov ntsiab lus tseem ceeb hauv kev tiv thaiv qog nqaij hlav lossis tiv thaiv qog nqaij hlav. TP53 yog cov noob uas sau cov protein p53, uas yog cov qog nqaij hlav. Yog li, TP53 noob qhia thiab tsim isomers ntawm p53 protein. p53 protein tswj lub voj voog ntawm tes thiab ua kom cov genome ruaj khov. Ntxiv mus, nws tiv thaiv genomic mutations uas tuaj yeem ua rau kev loj hlob ntawm cov qog nqaij hlav.
p53 yog dab tsi?
P53 yog 53 kDa hnyav protein uas ua raws li qog nqaij hlav. Yog li, nws tiv thaiv kev loj hlob ntawm qog. Qhov tseeb, nws tswj cov cell faib ntawm cov hlwb uas muaj peev xwm loj hlob yam tsis muaj kev tswj hwm. Tsis tas li ntawd, cov protein no muaj nyob rau hauv lub nucleus ncaj qha, khi nrog DNA. Thaum muaj kev puas tsuaj rau DNA, uas tuaj yeem ua rau qog nqaij hlav, p53 ua rau nws. Tsis tas li ntawd, cov protein no ua rau lwm cov noob los kho qhov kev puas tsuaj yog tias kho tau. Yog tias qhov kev puas tsuaj DNA tsis tuaj yeem kho tau, p53 tiv thaiv lub cell los ntawm kev faib tawm thiab qhia tias nws mus rau apoptosis. Yog li, p53 ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv qog nqaij hlav hauv peb lub cev.
Daim duab 01: p53 protein
Cov kws tshawb fawb hais txog cov protein no ua tus saib xyuas ntawm genome vim nws lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev hloov pauv ntawm genome thiab tiv thaiv peb ntawm qog.
TP53 yog dab tsi?
Tus TP53 yog cov noob uas sau rau p53 qog nqaij hlav protein. Tib neeg TP53 gene codes rau 15 p53 protein isoforms, xws li qhov loj ntawm 3.5 txog 43.7 kDa. Cov proteins no khi nrog genomic DNA thiab tswj cov noob kab lus thiab DNA puas tsuaj los tiv thaiv qog tsim. TP53 noob nyob rau ntawm caj npab luv ntawm chromosome 17 hauv tib neeg genome. Nws yog 20 kb ntev DNA ib ntus. Cov txheej txheem coding tau txais txiaj ntsig zoo hauv vertebrates.
Daim duab 02: TP53 noob ntawm chromosome 17
TP53 noob kev hloov pauv tsim cov mutant p53 proteins. Li-Fraumeni syndrome yog ib yam kab mob uas tsis tshua muaj tshwm sim los ntawm niam txiv mus rau cov xeeb ntxwv. Nws tshwm sim vim muaj kev hloov pauv hauv TP53 noob. Tsis tas li ntawd, qhov mob no ua rau muaj kev pheej hmoo ntawm qee yam mob qog noj ntshav xws li mob qog noj ntshav mis, mob qog nqaij hlav pob txha, leukemia, thiab cov qog nqaij hlav mos, thiab lwm yam. TP53 genetic test yog ib qho kev kuaj ntshav los yog pob txha. Nws ntsuas qhov kev hloov pauv hauv TP53 noob.
Dab tsi zoo sib xws ntawm p53 thiab TP53?
- TP53 noob muaj cov lus qhia caj ces los tsim p53 qog nqaij hlav protein.
- Ob leeg TP53 thiab p53 yog qhov tseem ceeb los tiv thaiv qog nqaij hlav.
- p53 tsub zuj zuj thiab TP53 hloov pauv yog cov cim qhia txog mob qog noj ntshav mis.
- Tsis tas li ntawd, TP53 noob kev hloov pauv ua rau kev tsim khoom thiab sib sau ntawm mutant p53 proteins.
Qhov txawv ntawm p53 thiab TP53 yog dab tsi?
P53 yog protein, hos TP53 yog noob. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm p53 thiab TP53. Qhov tseeb, TP53 noob yog cov noob uas nthuav tawm thiab tsim p53 qog-suppressing protein. Ntxiv mus, p53 protein hnyav ntawm 53kDa. Hauv qhov sib piv, TP53 noob yog 20 kb nucleotide ib ntus.
Cov infographic hauv qab no qhia txog qhov sib txawv ntawm p53 thiab TP53.
Summary – p53 vs TP53
p53 yog ib qho protein uas inhibits qog kev loj hlob. Hauv qhov sib piv, TP53 yog cov noob uas muaj cov ntaub ntawv caj ces los tsim p53 protein. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm p53 thiab TP53. Ntxiv mus, TP53 noob kev hloov pauv ua rau kev tsim cov protein ntau p53, ua rau muaj kev pheej hmoo ntawm ntau cov qog nqaij hlav hauv peb lub cev.
