Qhov sib txawv tseem ceeb ntawm neostigmine thiab pyridostigmine yog qhov neostigmine yog cov tshuaj muaj zog tshaj li pyridostigmine rau kev kho mob myasthenia gravis.
Myasthenia gravis yog ib qho mob autoimmune. Hauv qhov xwm txheej no, autoantibodies rhuav tshem kev sib txuas ntawm cov hlab ntsha thiab cov leeg, ua rau cov leeg pob txha tsis muaj zog. Yog li, myasthenia gravis cuam tshuam rau cov leeg ntawm lub cev. Cov leeg no, tshwj xeeb tshaj yog cov uas tswj lub qhov muag, qhov ncauj, caj pas, thiab ceg ceg. Qhov ncauj acetylcholine esterase inhibitors yog siv los kho myasthenia gravis. Neostigmine thiab pyridostigmine yog ob qhov ncauj acetylcholine esterase inhibitors siv rau kev kho mob myasthenia gravis.
Neostigmine yog dab tsi?
Neostigmine yog tshuaj muaj zog dua siv rau kev kho mob myasthenia gravis. Nws yog muag raws li hom npe bloxiverz. Nws kuj yog ib qho tshuaj siv rau kev kho mob ntawm lwm yam kab mob xws li Ogilvie syndrome thiab tso zis tso zis yam tsis muaj qhov thaiv. Ntxiv mus, nws kuj yog siv rau hauv tshuaj loog los xaus cov teebmeem ntawm cov tshuaj uas tsis yog-depolarising neuromuscular thaiv cov tshuaj. Feem ntau, cov tshuaj no yog muab los ntawm kev txhaj tshuaj, xws li mus rau hauv cov leeg, cov leeg lossis hauv qab ntawm daim tawv nqaij. Tom qab txhaj tshuaj Neostigmine, cov teebmeem feem ntau loj tshaj li ntawm 30 feeb thiab kav ntev txog 4 teev. Neostigmine cuam tshuam thiab tiv thaiv kev tawg ntawm acetylcholine (neurotransmitter) los ntawm acetylcholinesterase enzyme. Tsis tas li ntawd, neostigmine indirectly stimulates nicotinic thiab muscarinic receptors. Neostigmine khi rau anionic thiab ester site ntawm acetylcholinesterase enzyme, yog li thaiv cov enzyme los ntawm kev rhuav tshem cov acetylcholine molecules ua ntej cov molecules mus txog postsynaptic membrane receptors.
Daim duab 01: Neostigmine
Cov kev mob tshwm sim vim kev siv cov tshuaj no suav nrog xeev siab, nce qaub ncaug, mob plab, mob plawv dhia qeeb, ntshav siab tsis muaj zog, thiab ua xua. Neostigmine yog thawj patented nyob rau hauv 1931, thiab nws yog nyob rau hauv lub World He alth Organization cov npe ntawm cov tshuaj tseem ceeb.
YPyridostigmine yog dab tsi?
Pyridostigmine yog cov tshuaj tsis muaj zog siv rau kev kho mob myasthenia gravis. Nws kuj yog siv los kho cov zais zis tsis zoo. Cov tshuaj no yog siv ua ke nrog atropine los xaus cov teebmeem ntawm neuromuscular thaiv cov tshuaj uas tsis yog-depolarizing. Pyridostigmine feem ntau yog muab rau qhov ncauj. Txawm li cas los xij, nws tuaj yeem muab tau los ntawm kev txhaj tshuaj. Cov teebmeem ntawm pyridostigmine ib txwm pib li ntawm 45 feeb thiab kav ntev txog 6 teev.
Daim duab 02: Pyridostigmine
Cov kev mob tshwm sim ntawm cov tshuaj no suav nrog xeev siab, raws plab, tso zis ntau zaus, thiab mob plab. Cov kev mob tshwm sim loj dua ntawm pyridostigmine suav nrog ntshav siab, tsis muaj zog, thiab ua xua. Ntxiv mus, nws tsis paub meej tias kev siv cov tshuaj no thaum cev xeeb tub puas muaj kev nyab xeeb lossis tsis zoo rau tus menyuam hauv plab.
Tsis tas li ntawd, pyridostigmine yog ib qho acetylcholinesterase enzyme inhibitor hauv cholinergic tsev neeg ntawm cov tshuaj. Cov tshuaj no ua haujlwm los ntawm kev thaiv qhov kev txiav txim ntawm acetylcholinesterase enzyme, thiab nws nce qib ntawm acetylcholine. Pyridostigmine yog thawj patented nyob rau hauv 1945, thiab nws yog nyob rau hauv lub World He alth Organization cov npe ntawm cov tshuaj tseem ceeb.
Dab tsi yog qhov zoo sib xws ntawm Neostigmine thiab Pyridostigmine?
- Neostigmine thiab pyridostigmine yog ob qhov ncauj acetylcholine esterase inhibitors siv rau kev kho mob myasthenia gravis.
- Ob cov tshuaj ua haujlwm los ntawm kev thaiv qhov kev ua ntawm acetylcholinesterase enzyme thiab nce qib ntawm acetylcholine.
- Ob qho tshuaj muaj nyob hauv World He alth Organization's List of Essential Medicines.
- Lawv tau siv tshuaj loog kom xaus cov teebmeem ntawm cov tshuaj uas tsis yog-depolarising neuromuscular thaiv cov tshuaj.
Qhov txawv ntawm Neostigmine thiab Pyridostigmine yog dab tsi?
Neostigmine yog cov tshuaj muaj zog dua siv rau kev kho mob myasthenia gravis, thaum pyridostigmine yog cov tshuaj tsis muaj zog siv rau kev kho mob myasthenia gravis. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm neostigmine thiab pyridostigmine. Tsis tas li ntawd, neostigmine tau patented hauv 1931, thaum pyridostigmine tau patented hauv 1945.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm neostigmine thiab pyridostigmine hauv daim ntawv teev npe rau kev sib piv ntawm ib sab.
Summary – Neostigmine vs Pyridostigmine
Neostigmine thiab pyridostigmine yog ob qhov ncauj acetylcholine esterase inhibitors. Lawv tsuas yog siv rau kev kho mob ntawm myasthenia gravis. Neostigmine yog ib qho tshuaj muaj zog tshaj li pyridostigmine rau kev kho mob myasthenia gravis. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm neostigmine thiab pyridostigmine
