Qhov Tseem Ceeb - IGA vs IGG
Immunoglobulins yog hu ua ib hom tshwj xeeb ntawm globular proteins nrog cov qauv nyuaj. Lawv raug tsim los ntawm cov kab mob nyob ua ib qho kev tiv thaiv kab mob thib ob thaum sib cuag nrog cov tshuaj tiv thaiv kab mob txawv teb chaws los yog cov kab mob. Immunoglobulins tseem hu ua cov tshuaj tiv thaiv uas yog cov proteins tshwj xeeb uas tsim los rau cov tshuaj tiv thaiv. Lub tsib chav kawm ntawm cov tshuaj tiv thaiv yog - Immunoglobulin (Ig) A, G, M, E, D. Immunoglobulin A (IgA / IGG) yog ib qho secretory immunoglobulin tam sim no nyob rau hauv mucosal nto, muaj cov J saw thiab secretory polypeptide uas koom nrog. hauv kev ua haujlwm secretory. Immunoglobulin G (IgG / IGG) feem ntau koom nrog hauv kev tawm tsam cov kab mob txawv teb chaws uas suav nrog cov kab mob thiab kab mob. Qhov sib txawv tseem ceeb ntawm IGA thiab IGG yog qhov muaj thiab tsis muaj secretory polypeptide. IGA muaj cov secretory polypeptide los pab txhawb kev zais ntawm cov mucosal qhov chaw whereas IGG tsis muaj secretory muaj nuj nqi yog li, lub J saw yog tsis tuaj.
IGA yog dab tsi?
IGA yog ib hom immunoglobulin uas muaj lub luag haujlwm zais cia. Li no, IGA tuaj yeem pom muaj nyob hauv cov kua qaub xws li qaub ncaug thiab mis nyuj. Txog 50% ntawm cov protein muaj pes tsawg leeg ntawm colostrum yog IGA. Nws kuj yog secreted los ntawm mucosal khaubncaws sab nraud povtseg ntawm gastrointestinal ib ntsuj av thiab ua pa ib ntsuj av. Qhov no muab cov txheej txheem tiv thaiv tawm tsam cov kab mob nkag mus rau hauv plab lossis rau txoj hlab pa.
Daim duab 01: Tus qauv ntawm IGA
Muaj ob chav kawm tseem ceeb ntawm IGA; IGA 1 thiab IGA 2. IGA1 muaj thaj tsam pob khawm ntev dua thiab muaj cov txheej txheem ntxiv ntawm cov amino acids hauv nws cov qauv. Qhov no elongated pob khawm thaj tsam ua rau muaj kev nkag siab ntawm IGA1 rau cov kab mob proteases. Yog li ntawd, nws yog tam sim no feem ntau nyob rau hauv lub serum. IGA2 yog tsim los ntawm thaj tsam pob khawm luv, thiab nws tsis muaj cov amino acid duplicate qauv. Yog li ntawd, nws tsis muaj qhov rhiab heev rau protease. IGA2 yog tam sim no feem ntau nyob rau hauv mucous secreting membranes.
IGA tsim cov qauv dimer uas yog tus yam ntxwv ntawm hom immunoglobulin. Cov monomers tau koom nrog cov qauv hu ua J saw. J saw txuas mus rau cov qauv dimer ntawm kev sib txuas ntawm disulfide. Ib qho polypeptide yog txuam nrog cov qauv dimer uas ua raws li secretory polypeptide tivthaiv ntawm IGA. Lub luag haujlwm tseem ceeb ntawm IGAs yog los tiv thaiv cov khaubncaws sab nraud povtseg ntawm cov co toxins thiab tshuaj lom neeg xws li kab mob thiab kab mob. IGA koom nrog cov tshuaj tiv thaiv tsis zoo los ua kom cov khoom siv tshuaj lom.
IGG yog dab tsi?
IGG yog hom immunoglobulin ntau tshaj plaws nyob hauv lub cev. Nws tseem yog lub ntsiab lus tseem ceeb ntawm circulatory immunoglobulin hauv lub cev. IGG yog tib hom immunoglobulin uas tuaj yeem hla cov placenta thiab ncav cuag tus menyuam hauv plab. IGG muaj plaub polypeptide chains; 2 chains hnyav thiab 2 lub teeb chains uas txuas ua ke los ntawm inter chain disulfide linkages. Txhua cov saw hnyav muaj N-terminal variable domain (VH) thiab peb qhov chaw tas mus li (CH1, CH2, CH3), nrog rau qhov ntxiv "pob khawm" ntawm CH1 thiab CH2. Txhua lub teeb chains muaj N-terminal variable domain (VL) thiab ib qho chaw tas mus li (CL). Lub teeb saw yog txuam nrog VH thiab CH1 domains los tsim Fab caj npab ("Fab"=fragment antigen binding), thiab V cheeb tsam cuam tshuam los tsim thaj tsam antigen-binding. Ntxiv rau IGG kuj tseem muaj thaj chaw khaws cia zoo heev uas muaj glycosylated amino acid ntawm 297th txoj haujlwm.
Daim duab 02: Cov qauv dav dav ntawm IGG
IGG muaj plaub chav kawm loj xws li IgG1, IGG2, IGG3, thiab IGG4. IGG1 yog cov subclass tshaj plaws. Nws yog cov tshuaj tiv thaiv tam sim ntawd ua rau hauv lub cev thaum muaj kab mob los ntawm cov kab mob los yog tus kab mob. IGG2 yog tsim nyob rau hauv teb rau cov kab mob capsular antigens. Cov tshuaj tiv thaiv no teb rau cov carbohydrate-based antigens. Nws tuaj yeem ua rau cov kab mob uas muaj cov carbohydrate raws li antigens. IGG3 yog ib qho tshuaj tiv thaiv kab mob tiv thaiv kab mob uas feem ntau tsim los teb rau tus kab mob kis. IGG3 yog cov tshuaj tiv thaiv tseem ceeb uas tsim los teb rau cov pab pawg ntshav antigens. IGG4 cov tshuaj tiv thaiv yog tsim los teb rau cov kab mob ntev.
Qhov Zoo sib xws ntawm IGA thiab IGG yog dab tsi?
- Ob leeg yog tsim los ntawm kev tiv thaiv kab mob thib ob.
- Ob leeg yog tsim los teb rau cov tshuaj antigens lossis cov cim antigenic tsim hauv
- Ob leeg yog qhov tshwj xeeb heev.
- Ob leeg muaj plaub lub saw hlau polypeptide; 2 cov saw hnyav thiab 2 lub teeb sawb.
- Ob leeg koom nrog kev tawm tsam cov kab mob thiab kab mob.
Qhov txawv ntawm IGA thiab IGG yog dab tsi?
IGA vs IGG |
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| IGA yog ib qho tshuaj tiv thaiv uas muaj nyob rau hauv cov kua qaub thiab cov mucous membranes thiab tawm tsam cov kab mob thiab cov kab mob kis. | IGG yog ib qho tshuaj tiv thaiv uas tsim los ua lub cev tiv thaiv kab mob thib ob koom nrog kev sib ntaus sib tua tiv thaiv kab mob kis kab mob thiab kab mob. |
| faib | |
| IGA yog nyob rau hauv cov mucous daim nyias nyias thiab lub cev secretions xws li qaub ncaug thiab mis nyuj. | IGG yog nyob rau hauv tag nrho cov intra thiab ntxiv vascular ntaub so ntswg. |
| Txoj Kev Hnyav Hnyav | |
| IGA muaj Alpha hnyav saw. | IGG muaj Gamma hnyav saw. |
| Hauv cov ntshav, IGA concentration yog 0.6 - 3 mg / ml. | Nyob rau hauv Serum, IGG concentration yog 6 - 13 mg/ml. |
| J Chain | |
| Present in IGA. | Absent in IGG. |
| Secretory Polypeptide | |
| Present in IGA. | Absent in IGG. |
| Muaj peev xwm hla tus placenta | |
| IGA tsis tuaj yeem hla tus placenta. | IGG tuaj yeem hla tus placenta. |
Summary – IGA vs IGG
Ob leeg IGA thiab IGG yog tsim nyob rau hauv lub cev raws li kev tiv thaiv kab mob thib ob. Lawv yog cov tshuaj tiv thaiv tshwj xeeb uas ua los ntawm kev khi rau ib qho antigen tshwj xeeb. Qhov sib txawv loj ntawm ob lub immunoglobulins yog nyob ntawm kev ua haujlwm ntawm kev zais cia. IGA tam sim no yog cov kua dej secretory thiab nyob rau hauv cov mucous secreting membranes whereas, IGG yog cov ntau tshaj immunoglobulin nyob rau hauv cov ntshav. Ob leeg muaj peev xwm tiv thaiv cov kab mob microbial. Qhov no yog qhov txawv ntawm IGA thiab IGG.
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