Qhov sib txawv tseem ceeb ntawm tTG IgA thiab tTG IgG yog qhov tTG IgA yog ib qho kev sim siv los ntawm cov kws kho mob los kuaj cov kab mob celiac raws li kev tshawb pom ntawm transglutaminase IgA cov tshuaj tiv thaiv hauv tib neeg, thaum tTG IgG yog ib qho kev sim siv los ntawm cov kws kho mob. kuaj mob celiac raws li kev tshawb pom ntawm transglutaminase IgG cov tshuaj tiv thaiv hauv tib neeg.
kab mob Celiac yog ib qho kev tiv thaiv kab mob uas lub cev tiv thaiv kab mob tawm tsam nws cov ntaub so ntswg thaum tib neeg noj gluten. Qhov no ua rau cov hnyuv me (lub plab) puas thiab ua rau tsis muaj peev xwm noj cov as-ham. Kab mob Celiac tuaj yeem ua rau muaj ntau yam tsos mob, nrog rau raws plab, mob plab, thiab tsam plab. Tissue transglutaminase yog lub hom phiaj autoantigen hauv kab mob celiac. Cov tshuaj tiv thaiv no tau pom tias yog cov tshuaj tiv thaiv pom tau los ntawm cov tshuaj tiv thaiv kab mob (anti-transglutaminase antibodies: IgA, IgG) tshwj xeeb rau kab mob celiac. tTG IgA thiab tTG IgG yog ob qhov kev kuaj sim siv los kuaj kab mob celiac raws li kev tshawb pom ntawm cov tshuaj tiv thaiv transglutaminase hauv tib neeg.
TG IgA yog dab tsi?
tTG IgA yog ib qho kev sim siv los ntawm cov kws kho mob los kuaj xyuas kab mob celiac raws li kev tshawb pom ntawm transglutaminase IgA cov tshuaj tiv thaiv hauv tib neeg. Kab mob Celiac yog ib hom kab mob autoimmune uas lub cev tiv thaiv kab mob yuam kev "gluten" (uas yog ib qho protein nyob rau hauv nplej, barley, rye, thiab oats) raws li ib tug txawv teb chaws invader. Tus kab mob no cuam tshuam txog li 1% ntawm cov neeg thoob ntiaj teb. Ntawm no, lub cev tiv thaiv kab mob ua rau autoantibodies uas tawm tsam cov enzyme cov ntaub so ntswg transglutaminase (tTG) hauv cov hnyuv. tTG deamidates glutamine residues, tsim cov epitopes uas ua rau kom muaj kev sib raug zoo ntawm gluten protein rau cov tshuaj tiv thaiv T hlwb. Qhov no pib ua kom lub cev tiv thaiv kab mob hloov pauv.
Daim duab 01: Cov Kab Mob Celiac
tTG IgA kev ntsuam xyuas suav nrog kev kuaj pom cov ntaub so ntswg transglutaminase IgA cov tshuaj tiv thaiv uas tshwj xeeb rau kab mob celiac. Cov tib neeg uas muaj qhov nruab nrab mus rau qhov zoo tshaj plaws yog nyiam muaj kab mob celiac. Cov neeg mob no yuav tsum tau mus kuaj biopsy kom paub meej tias qhov kev kuaj mob. Tsis tas li ntawd, kev kho mob rau tus kab mob celiac yog kev noj zaub mov tsis muaj gluten. Hauv cov neeg mob feem ntau, kev noj zaub mov tsis muaj gluten txo qis qib ntawm autoantibodies thiab txhim kho atrophy.
TG IgG yog dab tsi?
tTG IgG yog ib qho kev kuaj mob uas kuaj xyuas kab mob celiac raws li kev nrhiav cov tshuaj tiv thaiv transglutaminase IgG hauv tib neeg. Qhov no yog ua tshwj xeeb rau cov tib neeg uas tsis muaj IgA.
Daim duab 02: Kev mob plab hnyuv mucosa uas ua rau Villous Atrophy
Nyob rau hauv cov tib neeg uas muaj qhov nruab nrab kom muaj txiaj ntsig zoo rau IgG autoantibodies, kev kuaj mob ntawm tus kab mob celiac yog ua tau. Cov neeg mob no yuav tsum tau mus kuaj biopsy kom paub meej tias qhov kev kuaj mob. Txawm li cas los xij, tTG IgG tsis tshua muaj siab thiab tsis tshua muaj tshwj xeeb thaum piv rau tTG IgA xeem.
Dab tsi yog qhov zoo sib xws ntawm tTG IgA thiab tTG IgG?
- tTG IgA thiab tTG IgG yog ob qhov kev kuaj sim rau kev kuaj mob celiac raws li kev tshawb pom ntawm cov tshuaj tiv thaiv transglutaminase.
- Ob qhov kev xeem yog kev kuaj serological.
- Lawv nyob ntawm seb muaj cov enzyme tshwj xeeb hu ua cov ntaub so ntswg transglutaminase
- Ob qhov kev sim yog enzyme-txuas immunosorbent assays.
- Tom qab ua tiav ob qhov kev sim, cov neeg mob yuav tsum tau mus kuaj ntshav kom paub meej tias qhov kev kuaj mob.
Qhov txawv ntawm tTG IgA thiab tTG IgG yog dab tsi?
tTG IgA yog ib qho kev sim siv los ntawm cov kws kho mob txhawm rau kuaj kab mob celiac raws li kev tshawb pom ntawm transglutaminase IgA cov tshuaj tiv thaiv hauv tib neeg, thaum tTG IgG yog ib qho kev sim siv los ntawm cov kws kho mob los kuaj kab mob celiac raws li kev tshawb pom ntawm transglutaminase IgG cov tshuaj tiv thaiv hauv cov neeg. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm tTG IgA thiab tTG IgG. Tsis tas li ntawd, tTG IgA yog qhov kev ntsuam xyuas tseem ceeb rau cov kab mob celiac, thaum tTG IgG tsis yog qhov kev ntsuam xyuas tseem ceeb rau tus kab mob celiac thiab ua tau tsuas yog thaum cov neeg mob tsis txaus hauv IgA autoantibodies.
Cov hauv qab no qhia txog qhov sib txawv ntawm tTG IgA thiab tTG IgG hauv daim ntawv teev npe rau kev sib piv ntawm ib sab.
Summary – tTG IgA vs tTG IgG
tTG IgA thiab tTG IgG yog ob qhov kev kuaj mob serological rau kev kuaj mob celiac raws li kev tshawb pom ntawm cov tshuaj tiv thaiv transglutaminase. tTG IgA kuaj kuaj kab mob celiac raws li kev tshawb pom ntawm transglutaminase IgA cov tshuaj tiv thaiv hauv tib neeg. Ntawm qhov tod tes, tTG IgG kuaj kuaj kab mob celiac raws li kev tshawb pom ntawm transglutaminase IgG cov tshuaj tiv thaiv hauv tib neeg. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm tTG IgA thiab tTG IgG.
