Qhov sib txawv tseem ceeb ntawm cov roj (cholesterol) zoo thiab cov roj (cholesterol) phem yog cov roj (cholesterol) zoo tshem tawm lwm hom roj cholesterol los ntawm peb cov hlab ntsha, txo qhov kev pheej hmoo ntawm cov kab mob plawv thaum cov roj (cholesterol) phem tsim nyob rau hauv cov phab ntsa ntawm peb cov hlab ntsha, ua rau lawv nqaim thiab ua rau. mob plawv thiab mob stroke.
Kev nce ntawm cov kab mob tsis sib kis thoob plaws ntiaj teb nyob rau tsib xyoos dhau los ua rau cov roj cholesterol yog cov ntsiab lus kub, thiab muaj kev kub ntxhov ntawm cov tib neeg los sau cov ntaub ntawv raug txog cov roj cholesterol. Cov roj (cholesterol) yog ib hom tshuaj muaj nyob hauv cov tsiaj. Nws yog macromolecule tsim los ntawm fatty acids thiab steroids. Cov roj (cholesterol) ua lub luag haujlwm tseem ceeb hauv kev tswj hwm kev noj qab haus huv los ntawm kev tsim cov cell membranes thiab cov tshuaj hormones xws li estrogen thiab testosterone. Nws kuj ua hauj lwm raws li ib tug intracellular tub txib. Endogenous tsim cov roj cholesterol feem ntau tshwm sim hauv daim siab. Cov zaub mov ua kom tiav cov roj cholesterol ntxiv.
Cov roj (cholesterol) zoo yog dab tsi?
Cov roj cholesterol zoo yog cov lipoproteins siab ntom ntom (HDL), thiab nws tsim kev tiv thaiv ntawm cov hlab plawv. Cov roj (cholesterol) zoo rho tawm lwm hom roj cholesterol los ntawm cov phab ntsa ntawm cov hlab ntsha thiab thauj lawv mus rau daim siab kom tso tawm raws li cov kua tsib. Yog li, lawv tiv thaiv kev tsim cov atherosclerotic plaques thiab txo qhov kev pheej hmoo ntawm cov kab mob plawv xws li mob plawv, mob stroke, thiab lwm yam. Yog li ntawd, qib HDL siab pab txhawb lub neej ntev thiab txo qhov mob. Hauv qhov sib piv, qib qis ntawm HDL yog lub luag haujlwm rau kev mob plawv thiab mob stroke ntau dua.
Daim duab 01: Cov roj (cholesterol) zoo thiab phem
Kev hloov pauv kev ua neej zoo thiab tshuaj noj xws li nicotinic acid, gemfibrozil, estrogen thiab statins tuaj yeem pab txhawb qib HDL.
Cov roj (cholesterol) phem yog dab tsi?
Cov roj (cholesterol) phem, lossis cov lipoproteins tsawg-density (LDL), nqa cov roj (cholesterol) tshiab los ntawm lub siab mus rau lwm cov ntaub so ntswg hauv lub cev. Nws ua rau atheroma tsim ua ntej, nce mus rau atherosclerosis nrog rau cov hlab ntsha nqaim thiab ua rau cov kab mob plawv (lub plawv nres thiab mob stroke) thaum muaj hnub nyoog ntxov, thiab tuag. HDL txo qhov kev pheej hmoo ntawm atheroma los ntawm kev tshem cov roj cholesterol los ntawm cov hlab ntsha. Tab sis, thaum qib HDL poob qis, LDL qib nce mus, ua rau muaj kev hem thawj saum toj no.
Daim duab 02: Atheroma
Kev hloov pauv txoj kev ua neej zoo thiab kev siv tshuaj raws li cov tshuaj statin, thiab rau qib qis dua nrog fibrates, nicotinic acid, gemfibrozil thiab resins zoo li cholestyramine tuaj yeem txo qis LDL.
Dab tsi yog qhov zoo sib xws ntawm cov roj (cholesterol) zoo thiab cov roj (cholesterol) phem?
- Cov no yog ob hom lipoproteins uas muaj rog thiab cov proteins.
- Cov roj (cholesterol) zoo tshem tawm cov roj (cholesterol) phem los ntawm cov hlab ntsha.
- Yog li, cov roj cholesterol zoo tswj cov qib ntawm cov cholesterol tsis zoo.
- Tsis tas li ntawd, cov qib zoo ntawm cov roj (cholesterol) zoo thiab qhov tsis zoo yog qhov tsim nyog txhawm rau txo qis kev pheej hmoo ntawm cov kab mob plawv.
- Ntxiv mus, lawv muaj qhov zoo sib xws hauv cov pleev ntawm cov qib molecular nrog cov taub hau hydrophilic jutting thiab hydrophobic / lipophilic tails jutting rau hauv cov lus zais cov roj cholesterol.
Qhov txawv ntawm cov roj (cholesterol) zoo thiab cov cholesterol phem yog dab tsi?
Cov roj (cholesterol) zoo (HDL) pab tshem tawm lwm hom roj cholesterol los ntawm cov hlab ntsha thaum cov roj cholesterol phem (LDL) tsim nyob rau hauv cov phab ntsa ntawm cov hlab ntsha, ua rau cov kab mob plawv. Qhov no yog qhov sib txawv tseem ceeb ntawm cov roj (cholesterol) zoo thiab cov roj (cholesterol) phem. Kev ua haujlwm, qib HDL yuav tsum nyob rau hauv qhov siab thiab qib LDL yuav tsum nyob rau hauv qhov qis, kom muaj kev noj qab haus huv zoo. Lwm qhov sib txawv ntawm cov roj (cholesterol) zoo thiab cov roj (cholesterol) phem yog HDL thauj cov roj cholesterol los ntawm cov ntaub so ntswg mus rau lub siab kom tawm, thaum LDL thauj lawv los ntawm lub siab mus rau cov ntaub so ntswg kom tso.
Tsis tas li ntawd, muaj lwm qhov sib txawv ntawm cov roj (cholesterol) zoo thiab cov roj (cholesterol) phem raws li cov tshuaj siv los txo LDL thiab nce HDL cholesterol. Hauv kev txo qis LDL qib, cov tshuaj statin muaj lub luag haujlwm tseem ceeb hauv kev ua si, thaum nce qib HDL nws yog feeb. Tsis tas li ntawd, nicotinic acids, fibrates, thiab gemfibrozil muaj feem cuam tshuam rau kev nce HDL, thaum nws txo qis hauv LDL qib los ntawm qhov tsis txaus ntseeg. Ntxiv mus, resin cholestyramine ua kom txo qis LDL qib, tab sis nws tsis cuam tshuam rau qib HDL.
Summary - Cov roj (cholesterol) zoo vs cov roj (cholesterol) phem
Cov roj cholesterol zoo thiab phem yog ob hom roj cholesterol. Cov roj cholesterol zoo yog cov lipoproteins siab ceev thaum cov roj cholesterol tsis zoo yog lipoproteins tsawg. Qib siab ntawm cov roj (cholesterol) phem yog lub luag haujlwm rau atherosclerosis, ua rau mob hnyav thiab tuag taus. Hauv qhov sib piv, qib siab ntawm cov roj cholesterol zoo yog lub luag haujlwm rau kev noj qab haus huv thiab tsis tshua muaj kev pheej hmoo ntawm cov kab mob plawv. Ntau tshaj ib qho tshuaj yog tsim nyog los txo qis LDL qib, thiab nce qib HDL hauv qhov tseem ceeb. Yog li, qhov no yog cov ntsiab lus ntawm cov roj (cholesterol) zoo thiab cov roj (cholesterol) phem.
