Qhov sib txawv tseem ceeb ntawm Prostaglandin E1 thiab E2 yog qhov prostaglandin E1 (PGE1) yog ib qho tshuaj tiv thaiv kab mob thaum Prostaglandin E2 (PGE2) yog qhov ua rau mob.
Prostaglandins yog cov tshuaj lipid-derived uas muaj cov haujlwm zoo li tshuaj hormones. Lawv tuaj yeem ua raws li autocrine lossis paracrine tebchaw ua rau muaj kev tawm tsam lossis kev sib koom ua ke hauv cov kabmob muaj sia. Prostaglandin E1 thiab prostaglandin E2 yog ob hom, thiab lawv txawv ntawm kev ua haujlwm hauv qhov mob. Ob leeg prostaglandin E1 thiab E2 yog tib tsev neeg ntawm prostaglandin E2, thiab lawv lub hauv paus ntawm cov tshuaj tiv thaiv thiab lawv cov teebmeem tseem tsis tau meej meej. Lawv yog siv rau hauv kev kho mob ntawm ntau yam biochemical mechanisms nyob rau hauv creatures.
YProstaglandin E1 yog dab tsi?
Prostaglandin E1 (PGE1) muab los ntawm omega 6 fatty acids. Txawm li cas los xij, cov kws kho mob xa nws li alprostadil. Nws yog ib txwm tshwm sim los tiv thaiv inflammatory yam uas ua haujlwm los txo qhov mob. Nws ua los ntawm prostaglandin E2 receptor, txawm hais tias txoj hauv kev ntawm ligand khi thiab nws cov txheej txheem tseem tsis tau meej meej. PGE1 yog ib qho tseem ceeb hauv kev kho mob erectile kawg, qhov twg PGE1 txhaj rau hauv noov ua kev kho mob. Tsis tas li ntawd, PGE1 yog vasodilator thiab ua haujlwm los ntawm kev qhib cov hlab ntsha los ntawm kev so ntawm cov leeg nqaij.
Daim duab 01: Prostaglandin E1
Cov kev mob tshwm sim ntawm kev tswj hwm ntawm PGE1 suav nrog qhov mob ntawm tes, los ntshav ntawm qhov chaw txhaj tshuaj thiab cov teebmeem xws li ntshav siab, ua tsis taus pa thiab kub taub hau.
YProstaglandin E2 yog dab tsi?
Prostaglandin E2 (PGE2) yog lipid-derived natural prostaglandin uas ua haujlwm zoo li qhov ua rau muaj qhov ua rau ua rau mob ntawm Wnt txoj kev taw qhia. Lub receptor ntawm PGE2 belongs rau prostaglandin E2 tsev neeg receptor.
Dinoprostone yog ib qho tshuaj uas muaj prostaglandin E2. Yog li ntawd, cov tshuaj no yog siv raws li ib tug tshuaj rau induce mob mob, induce los ntshav tom qab yug me nyuam thiab induce lub cev xeeb tub. PGE2 kuj tau muab rau cov menyuam mos uas muaj lub plawv tsis xws luag thiab ua rau qhib thiab ua kom cov hlab ntsha.
Daim duab 02: Prostaglandin E2
Ntxiv mus, cov kev mob tshwm sim ntawm PGE2 kev tswj hwm suav nrog ua npaws, raws plab thiab ntuav. Thaum muab tshuaj thaum lub sij hawm yug me nyuam, nws induces ntau uterine contractions.
Dab tsi yog qhov zoo sib xws ntawm Prostaglandin E1 thiab E2?
- Prostaglandin E1 thiab E2 muab los ntawm arachidonic acid.
- Ob leeg yog hom omega 6 fatty acids.
- Lawv ua raws li cov tshuaj hormones hauv kev tswj cov kev taw qhia.
- Prostaglandin E1 thiab E2 sib koom tib yam receptor.
- Ob leeg muaj kev phiv tom qab kev tswj hwm raws li kev kho mob. Tsis tas li ntawd, lawv qhia qee qhov kev cuam tshuam tshwj xeeb ib yam nkaus.
- Lawv ua phem rau ib leeg.
Qhov txawv ntawm Prostaglandin E1 thiab E2 yog dab tsi?
Prostaglandin E1 thiab E2 yog ob hom prostaglandins thiab lawv ob leeg sib koom tib receptors. Txawm li cas los xij, PGE1 yog ib qho tshuaj tiv thaiv kab mob thaum PGE2 yog qhov ua rau mob. Qhov no yog qhov sib txawv tseem ceeb ntawm prostaglandin E1 thiab E2. Lwm qhov sib txawv ntawm prostaglandin E1 thiab E2 yog nyob rau hauv lawv txoj haujlwm hauv kev kho mob. Kev siv ntau ntawm prostaglandin E1 yog los kho erectile kawg whereas kev siv ntau ntawm prostaglandin E2 yog ua kom uterine contractions thiab pab hauv kev yug menyuam.
Summary – Prostaglandin E1 vs E2
Prostaglandins ua lub luag haujlwm tseem ceeb hauv kev ntsuas kev ua haujlwm biochemical hauv cov kab mob muaj sia. Yog li, lawv yog lipid-derived ntev-chain fatty acids uas muaj cov qauv monomer ntawm omega 6 fatty acids. Yog li ntawd, ob hom, PGE1 thiab PGE2, muaj nyob rau hauv prostaglandin E2 receptor tsev neeg thiab ua haujlwm antagonistically. PGE1 yog ib qho tshuaj tiv thaiv kab mob, qhov PGE2 yog qhov ua rau muaj qhov ua rau mob. PGE1 siv nyob rau hauv kev kho mob ntawm erectile kawg thaum PGE1 siv los ntxias cov neeg ua haujlwm thaum lub sijhawm xa khoom. Qhov no yog qhov txawv ntawm prostaglandin E1 thiab E2.
