Qhov sib txawv tseem ceeb ntawm cov noob ntxiv thiab hloov cov noob yog qhov sib ntxiv ntawm cov noob yog qhov ntxig ntawm cov noob los ntawm cov noob uas tsis yog homologous recombination thaum lub noob hloov yog hloov cov noob endogenous los ntawm homologous recombination.
Gene therapy yog ib txoj kev siv cov noob los kho cov kab mob caj ces. Yog li, nws cuam tshuam txog kev taw qhia lossis xa cov noob rau hauv cov neeg mob lub cell. Hauv lwm lo lus, kev kho cov noob muaj xws li hloov lossis ntxiv cov noob nyob rau hauv qhov chaw ntawm cov noob tsis raug lossis kab mob. Hauv cov txheej txheem no, xaiv cov noob raug rau kev hloov lossis ntxiv yog qhov tseem ceeb. Yog li ntawd, txoj kev kho noob tseem tsis tau ua tiav 100% rau kev kho mob tib neeg. Ntau yam kab mob caj ces tsis tuaj yeem kho nrog kev kho noob. Tab sis kev kho noob yog ib qho kev kho mob zoo rau ob peb kab mob xws li cov leeg nqaij dystrophy thiab cystic fibrosis, thiab lwm yam.
Dab tsi yog Gene Ntxiv?
Gene ntxiv yog ib txoj hauv kev zoo tshaj plaws hauv kev kho noob. Nws yog cov txheej txheem ntawm kev ntxig lossis tsuas yog ntxiv cov noob los ntawm kev sib txuas tsis yog homologous. Cov gene ntxiv tuaj yeem yog cov ntawv luam tawm ntawm cov noob tsis zoo. Gene ntxiv txheej txheem yuav tsum muaj vector system. Viral lossis non-virus raws li vectors tau ua tiav siv rau qhov xwm txheej no. Retroviruses yog cov vectors ua tau zoo tshaj plaws uas tau sim mus txog rau tam sim no rau cov txheej txheem gene ntxiv vim lawv qhov hloov tau zoo rau kev xa cov noob rau hauv cov hlwb.
Daim duab 01: Kev Kho Mob Ntshav
Ntxiv mus, nrog rau kev sib piv rau kev hloov noob caj noob ces, ntxiv cov noob tau zoo dua. Txawm li cas los xij, muaj ntau yam zoo ib yam. Ib qho tsis zoo yog qhov tsis sib haum xeeb ntawm cov noob rau hauv cov genome. Vim li no, cov noob caj noob ces yuav raug qhia yuam kev lossis tsis tsim nyog.
Kev Hloov Gene yog dab tsi?
Gene hloov yog ib qho txheej txheem ntawm kev hloov cov noob endogenous ntawm nws qhov chaw qub hauv genome. Nws suav nrog homologous recombination. Siv cov noob hloov, nws muaj peev xwm tshem tawm cov noob, tshem tawm exons, ntxiv cov noob thiab qhia cov kev hloov pauv, thiab lwm yam.
Tsis tas li ntawd, kev hloov noob caj noob ces tuaj yeem ua tau mus tas li lossis xwm yeem. Yog li ntawd, kev tsim cov vector yog qhov tseem ceeb rau cov txheej txheem no vim tias vector yuav tsum xa cov noob tshiab rau hauv qhov chaw ntawm lub genome. Tsis tas li ntawd, kev hloov pauv yog cov txheej txheem yooj yim uas qhia cov noob tshiab rau hauv tus tswv tsev. Qhov tseem ceeb tshaj, kev hloov cov noob yog ib qho kev hloov pauv ntawm cov pob txha pob txha lossis cov qia hlwb.
Dab tsi yog qhov zoo sib xws ntawm Gene Addition and Gene Replacement?
- Gene ntxiv thiab hloov cov noob yog ob txoj kev kho noob.
- Siv ob lub tswv yim, cov noob tuaj yeem nkag mus rau cov nroj tsuag, microbes, thiab tsiaj ua tiav.
Dab tsi yog qhov txawv ntawm Gene Addition and Gene Replacement?
Ib qho kev ntxig lossis ntxiv ntawm cov noob los ntawm qhov tsis yog homologous recombination yog cov txheej txheem ntawm cov noob ntxiv. Ntawm qhov tod tes, kev hloov ntawm cov noob tsis zoo nrog cov noob muaj tseeb los ntawm homologous recombination yog cov txheej txheem ntawm kev hloov cov noob. Tsis tas li ntawd, kev ntxiv cov noob muaj txiaj ntsig zoo dua li kev hloov cov noob. Cov nram qab no infographic nthuav tawm qhov sib txawv ntawm cov noob ntxiv thiab hloov noob hauv daim ntawv tabuar.
Summary – Gene Addition vs Gene Replacement
Gene ntxiv thiab hloov cov noob yog ob lub tswv yim ntawm kev kho noob. Nyob rau hauv tas li ntawd mus gene, ib tug gene yog tso thaum nyob rau hauv lub gene hloov, ib tug gene yog hloov. Ob lub tswv yim yuav tsum muaj vector system los qhia cov noob. Ntxiv mus, vim cov txheej txheem no, peb tuaj yeem kho thiab tiv thaiv kab mob caj ces. Qhov no yog qhov txawv ntawm cov noob ntxiv thiab hloov cov noob.
