Qhov Tseem Ceeb - TH1 vs TH2 Pab Cells
Type 1 T helper (TH1) cells thiab Type 2 T helper (TH2) cells yog ob hom T pab hlwb uas tuaj yeem paub qhov txawv ntawm hom cytokines uas lawv zais cia. TH1 hlwb secrete interferon-γ (IFN-γ) thiab qog necrosis factor-α (TNF-α) thiab feem ntau tiv thaiv kab mob tiv thaiv kab mob intracellular. TH2 hlwb secrete interleukins 4, 5, 10, thiab 13 (IL-4, IL-5, IL-10, thiab IL-13) thiab feem ntau tiv thaiv kab mob tiv thaiv cov kab mob extracellular. Qhov no yog qhov txawv ntawm TH1 thiab TH2.
cov qe ntshav dawb yog ib feem tseem ceeb ntawm peb lub cev tiv thaiv kab mob. Cov hlwb no tiv thaiv peb lub cev los ntawm cov kab mob sib kis thiab txawv teb chaws antigens. Muaj ntau hom qe ntshav dawb. Ntawm lawv, lymphocyte yog subtype. Peb hom lymphocytes muaj nyob rau hauv vertebrate lub cev tiv thaiv kab mob uas yog, T hlwb, B hlwb thiab Natural killer cells. T hlwb los yog thymus hlwb yog ib qho ntawm cov cellular Cheebtsam nyob rau hauv lub adaptive tiv thaiv kab mob. Lawv paub cov antigens txawv teb chaws thiab koom nrog hauv cell mediated tiv thaiv. T hlwb yog tus cwj pwm los ntawm qhov muaj T cell receptors ntawm lub xov tooj ntawm tes. T hlwb los yog T lymphocytes yog ob peb hom loj ntawm lawv T hlwb tseem hu ua CD4+ T hlwb yog ib hom. T pab hlwb nthuav qhia CD4 glycoprotein ntawm lawv lub xovtooj ntawm tes, thiab lawv tau ua haujlwm thaum peptide antigens nthuav tawm los ntawm MHC class II molecules. Thaum ua kom muaj zog, T pab hlwb sib txuas sai sai thiab zais cytokines thiab kev loj hlob yam tseem ceeb uas pab thiab tswj hwm lwm lub cev tiv thaiv kab mob thiab cov lus teb. Helper T hlwb tuaj yeem muab faib ua ntau hom subtypes xws li TH1, TH2, TH3, TFH, TH17 thiab TH9. Cov subtypes no zais cov cytokines sib txawv uas pab txhawb ntau hom kev tiv thaiv kab mob.
TH1 Cells yog dab tsi?
Type 1 T helper (TH1) hlwb yog ib hom pab T hlwb uas txawv ntawm naïve T pab hlwb. TH1 hlwb txawv ntawm lwm cov T pab hlwb ua haujlwm vim muaj kev tso tawm ntawm cov cytokines sib txawv. TH 1 hlwb secrete interferon-γ (IFN-γ) thiab qog necrosis factor-α (TNF-α). Los ntawm qhov cytokine secretion, nws tuaj yeem paub qhov txawv ntawm hom 2 pab hlwb yooj yim.
Daim duab 01: TH1 Cells Keeb Kwm
TH1 hlwb kuj tseem ua kom cov macrophages rhuav tshem cov kab mob uas nyob hauv cov macrophages 'phagosomes. Lawv kuj tseem pab txhawb rau kev ua kom cov cytotoxic T hlwb los rhuav tshem cov kab mob. Los ntawm saib cov haujlwm ntawm TH1 hlwb, nws yog qhov tseeb tias TH1 hlwb feem ntau cuam tshuam nrog kev tiv thaiv kab mob los ntawm cov kab mob intracellular. Thiab tseem TH1 hlwb txhawb B hlwb kom zais cov tshuaj tiv thaiv tshwj xeeb xws li IgG, uas yog tsim nyog los npog cov kab mob ntxiv.
TH2 Cells yog dab tsi?
Type 2 helper T cells (TH2 cells) yog lwm hom T pab hlwb uas txawv ntawm naïve T pab hlwb. TH2 hlwb secrete interleukins 4, 5, 10, thiab 13 (IL-4, IL-5, IL-10, thiab IL-13) thiab feem ntau koom nrog hauv kev tiv thaiv kab mob tiv thaiv kab mob extracellular.
Daim duab 02: T pab Cell Ua kom
TH2 hlwb muaj peev xwm ua kom B hlwb tsim feem ntau ntawm cov tshuaj tiv thaiv antigens suav nrog IgE thiab qee cov chav kawm ntawm IgG uas khi rau mast hlwb, basophils thiab eosinophils. Thiab tseem TH2 hlwb tau koom nrog kev tso tawm cov neeg nruab nrab hauv zos uas ua rau txham, hnoos, lossis raws plab kom tshem tawm cov kab mob hauv lub cev.
Dab tsi zoo sib xws ntawm TH1 thiab TH2 Pab Cells?
- Ob leeg TH1 thiab TH2 hlwb raug tsim tawm thaum tsis muaj T pab hlwb ua haujlwm hauv cov ntaub so ntswg peripheral lymphoid.
- Ob lub hlwb tsim cytokines uas tsim nyog los qhib lwm lub cev tiv thaiv kab mob.
- Ob leeg muab lub hauv paus rau kev tsim cov tshuaj tiv thaiv tshiab.
- Ob lub hlwb muab lub hauv paus rau kev txhim kho txoj kev kho tshiab rau kev ua xua thiab kab mob autoimmune.
- Ob lub hlwb pib qhia CCR7 (CC chemokine receptor 7).
Qhov txawv ntawm TH1 thiab TH2 Pab Cells yog dab tsi?
TH1 vs TH2 Helper Cells |
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| TH1 hlwb yog ib hom sib txawv T pab hlwb uas feem ntau koom nrog hauv kev tiv thaiv lub cev los ntawm cov kab mob hauv lub cev. | TH2 hlwb yog ib hom kev sib txawv ntawm T pab hlwb uas feem ntau koom nrog kev tiv thaiv lub cev los ntawm cov kab mob extracellular. |
| Hom Cytokine tsim tawm | |
| TH1 hlwb secrete interferon-γ (IFN-γ) thiab qog necrosis factor-α (TNF-α). | TH2 hlwb secrete interleukins 4, 5, 10, thiab 13 (IL-4, IL-5, IL-10, thiab IL-13). |
| TH1 hlwb tsuas yog tiv thaiv kab mob tiv thaiv kab mob hauv lub cev. | TH2 hlwb feem ntau tiv thaiv kab mob tiv thaiv kab mob ntxiv. |
| Lwm yam haujlwm | |
| TH1 hlwb yuav qhib cov macrophages los tua microbes nyob rau hauv macrophages 'phagosomes, qhib cytotoxic T hlwb los tua cov kab mob thiab txhawb B hlwb kom secrete subclasses ntawm IgG tshuaj tiv thaiv. | TH2 hlwb yuav txhawb nqa B hlwb los tsim ntau hom tshuaj tiv thaiv, suav nrog IgE thiab qee cov subclasses ntawm IgG cov tshuaj tiv thaiv thiab tso tawm cov neeg kho mob hauv zos uas ua rau txham, hnoos, lossis raws plab thiab pab tshem tawm cov kab mob extracellular microbes thiab cov kab mob loj dua los ntawm cov kab mob epithelial. lub cev. |
Summary –TH1 vs TH2 Helper Cells
T pab hlwb yog ib lub hlwb tseem ceeb hauv kev tiv thaiv kab mob. Lawv qhib B hlwb, macrophages thiab cytotoxic T hlwb los tsim cov tshuaj tiv thaiv tawm tsam txawv teb chaws antigens, rhuav tshem cov microbes noj thiab ua kom cov kab mob kis tau raws li. Hom 1 pab T hlwb thiab hom 2 pab T hlwb yog ob subtypes ntawm pab T hlwb. Ob hom no ua haujlwm sib txawv thiab tuaj yeem sib txawv los ntawm hom cytokines lawv zais cia. Th1 hlwb secrete interferon-γ (IFN-γ) thiab qog necrosis factor-α (TNF-α) thaum Th2 hlwb secrete interleukins 4, 5, 10, thiab 13 (IL-4, IL-5, IL-10, thiab IL. -13). Th1 hlwb nqa tawm cell mediated tiv thaiv thaum TH2 hlwb muab humoral tiv thaiv. Qhov no yog qhov txawv ntawm TH1 thiab TH2 hlwb.
