Qhov sib txawv tseem ceeb ntawm bullous pemphigoid thiab pemphigus vulgaris yog qhov bullous pemphigoid yog ib qho mob autoimmune ntawm daim tawv nqaij tshwm sim vim yog autoantibodies tiv thaiv hemidesmosomes, thaum pemphigus vulgaris yog autoimmune tawv nqaij mob tshwm sim vim autoantibodies tiv thaiv desmoglein.
Kab mob autoimmune yog ib qho teeb meem uas tib neeg lub cev tawm tsam nws tus kheej. Hauv qhov no, cov tshuaj tiv thaiv tawm tsam cov ntaub so ntswg noj qab haus huv es tsis txhob muaj teeb meem. Qhov no ua rau muaj ntau yam tsos mob sib txawv thiab muaj kev phom sij rau cov pob qij txha, cov kab mob hauv nruab nrog cev, thiab daim tawv nqaij. Bullous pemphigoid thiab pemphigus vulgaris yog ob hom kab mob autoimmune ntawm daim tawv nqaij.
Bullous Pemphigoid yog dab tsi?
Bullous pemphigoid yog ib qho mob autoimmune ntawm daim tawv nqaij uas tshwm sim vim autoantibodies tawm tsam hemidesmosomes. Cov hemidesmosomes yog multiprotein complexes uas pab kom ruaj khov adhesion ntawm basal epithelial hlwb mus rau hauv qab daus daim nyias nyias. Nws yog ib qho tsis tshua muaj kab mob ntawm daim tawv nqaij feem ntau cuam tshuam rau cov neeg laus. Bullous pemphigoid feem ntau pib ua khaus, tsa pob khaus ntawm daim tawv nqaij. Raws li nws loj hlob, nws hloov mus rau hauv cov hlwv loj tsim ntawm daim tawv nqaij. Tus mob no yuav kav ntev li ob peb xyoos thiab qee zaum tuaj yeem ua teeb meem loj.
Daim duab 01: Bullous Pemphigoid
Bullous pemphigoid tsis kis tau, tshwm sim los ntawm kev ua xua, lossis cuam tshuam los ntawm kev noj haus lossis kev ua neej. Qee lub sij hawm nws tau txuas rau cov tawv nqaij puas tsuaj los ntawm tshav ntuj los yog noj qee yam tshuaj. Cov tsos mob thiab cov tsos mob yuav muaj xws li khaus tawv nqaij lub lis piam los yog hli ua ntej hlwv tshwm sim, hlwv loj uas tsis yooj yim rupture thaum kov, ib txwm tawv nqaij nyob ib ncig ntawm lub hlwv, reddish los yog tsaus dua li qub, eczema, thiab hlwv me me los yog mob nyob rau hauv lub qhov ncauj los yog lwm yam mucous daim nyias nyias.
Bullous pemphigoid tuaj yeem kuaj tau los ntawm kev kuaj lub cev, kuaj ntshav, lossis kuaj tawv nqaij. Tsis tas li ntawd, kev kho mob rau bullous pemphigoid tuaj yeem suav nrog cov tshuaj xws li corticosteroids, tshuaj steroids-sparing (azathioprine), thiab lwm yam tshuaj uas tawm tsam qhov mob (methotrexate).
Pemphigus Vulgaris yog dab tsi?
Pemphigus Vulgaris yog ib qho mob autoimmune ntawm daim tawv nqaij uas tshwm sim vim autoantibodies tawm tsam desmoglein. Desmoglein yog ib qho zoo li cadherin adhesion molecule uas pab tswj cov ntaub so ntswg ncaj ncees. Cov proteins no kuj pab txhawb kev sib txuas lus ntawm tes-rau-cell. Nws yog ib hom kab mob autoimmune tsawg. Pemphigus Vulgaris feem ntau cuam tshuam rau cov neeg muaj hnub nyoog thawj koom ruam 30 txog 60 xyoo.
Daim duab 02: Pemphigus Vulgaris
Nws ua rau pob khaus ntawm daim tawv nqaij thiab cov mucous membranes thoob plaws lub cev. Pemphigus Vulgaris tuaj yeem cuam tshuam rau lub qhov ncauj, qhov ntswg, caj pas, qhov muag, thiab qhov chaw mos. Cov hlwv ib txwm mob tab sis tsis khaus. Ntxiv mus, hlwv hauv qhov ncauj lossis caj pas yuav ua rau nws nqos thiab noj tsis yooj yim. Cov xwm txheej no feem ntau pom nyob rau hauv cov neeg Yudais thiab Khab Khab dua li lwm haiv neeg, xav tias yog vim li cas caj ces. Pemphigus Vulgaris tuaj yeem kuaj tau los ntawm kev kuaj lub cev, kuaj tawv nqaij, kuaj ntshav, thiab kuaj ntshav. Tsis tas li ntawd, cov kev kho mob rau pemphigus vulgaris muaj xws li tshuaj xws li corticosteroids, steroid-sparing immunosuppressant tshuaj (azathioprine, mycophenolate, thiab cyclophosphamide), thiab lwm yam tshuaj xws li dapsone, intravenous immunoglobulins, los yog rituximab.
Dab tsi zoo sib xws ntawm Pemphigoid thiab Pemphigus Vulgaris?
- Bullous pemphigoid thiab pemphigus vulgaris yog ob hom kab mob autoimmune ntawm daim tawv nqaij.
- Ob leeg yog cov tawv nqaij tsis tshua muaj.
- Nyob rau hauv ob qho xwm txheej, hlwv ntawm daim tawv nqaij tuaj yeem txheeb pom.
- Ob daim tawv nqaij mob tuaj yeem kuaj tau los ntawm kev kuaj lub cev.
- Lawv tuaj yeem kho tau los ntawm cov tshuaj xws li corticosteroids.
Qhov txawv ntawm Bullous Pemphigoid thiab Pemphigus Vulgaris yog dab tsi?
Bullous pemphigoid yog ib qho mob autoimmune ntawm daim tawv nqaij uas tshwm sim vim autoantibodies tiv thaiv hemidesmosomes, thaum pemphigus vulgaris yog ib qho mob autoimmune ntawm daim tawv nqaij uas tshwm sim vim autoantibodies tiv thaiv desmoglein. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm bullous pemphigoid thiab pemphigus vulgaris. Tsis tas li ntawd, bullous pemphigoid feem ntau tuaj yeem pom hauv cov neeg muaj hnub nyoog 50 txog 80 xyoo. Ntawm qhov tod tes, pemphigus vulgaris feem ntau pom nyob rau hauv cov neeg muaj hnub nyoog 30 txog 60 xyoo.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm bullous pemphigoid thiab pemphigus vulgaris hauv daim ntawv tabular rau kev sib piv ntawm ib sab.
Summary – Bullous Pemphigoid vs Pemphigus Vulgaris
Bullous pemphigoid thiab pemphigus vulgaris yog ob yam kab mob autoimmune tsis tshua muaj tawv nqaij. Bullous pemphigoid tshwm sim vim autoantibodies tawm tsam hemidesmosomes, thaum pemphigus vulgaris tshwm sim vim autoantibodies tawm tsam desmoglein. Hauv ob qho xwm txheej, hlwv tuaj yeem pom ntawm daim tawv nqaij. Yog li, qhov no qhia txog qhov sib txawv ntawm bullous pemphigoid thiab pemphigus vulgaris.
