Qhov sib txawv tseem ceeb ntawm calcitonin thiab parathyroid hormone yog calcitonin yog peptide hormone uas txo cov ntshav cov ntsiab lus calcium, thaum parathyroid hormone yog peptide hormone uas ua rau cov ntshav concentration ntawm calcium.
Cov qib calcium uas ib txwm nyob hauv lub cev yog 8-10 mg / dL (2-2.5 mmol / L). Calcium yog ib qho tseem ceeb tshaj plaws thiab ib qho tseem ceeb ntawm cov zaub mov rau tib neeg lub cev. Tib neeg lub cev xav tau nws los tsim thiab kho cov pob txha thiab cov hniav, pab cov hlab ntsha ua haujlwm, pab txhawb cov leeg nqaij sib koom ua ke, pab ntshav txhaws thiab pab lub plawv ua haujlwm. Yuav luag tag nrho cov calcium hauv tib neeg lub cev yog khaws cia hauv cov pob txha. Cov calcium uas tseem tshuav muaj nyob rau hauv cov kua dej ntxiv (serum) thiab cov ntaub so ntswg zoo li cov leeg pob txha. Calcitonin thiab parathyroid hormone yog ob lub peptide cov tshuaj hormones uas yog qhov tseem ceeb los tswj cov ntshav calcium concentration.
Calcitonin yog dab tsi?
Calcitonin yog peptide hormone secreted los ntawm parafollicular lossis C hlwb ntawm cov thyroid caj pas hauv tib neeg thiab lwm cov chordates. Nws muaj 32 amino acids. Keeb kwm, nws kuj tau hu ua thyrocalcitonin. Calcitonin yog thawj zaug purified thiab nrhiav tau nyob rau hauv 1962 los ntawm Douglas Harold Copp thiab B. Cheney ntawm University of British Columbia, Canada. Lub luag haujlwm tseem ceeb ntawm calcitonin yog txhawm rau txo cov ntshav hauv cov calcium. Calcitonin muaj qhov cuam tshuam rau cov tshuaj parathyroid hormone (PTH). Qhov tseem ceeb ntawm calcitonin hauv tib neeg tsis tau tsim kom zoo raws li nws qhov tseem ceeb hauv lwm yam tsiaj. Qhov no yog vim nws txoj haujlwm ib txwm tsis tseem ceeb hauv kev tswj hwm ntawm calcium homeostasis. Ntxiv mus, nws belongs rau tsev neeg cov protein zoo li calcitonin.
Daim duab 01: Calcitonin
Calcitonin yog tsim los ntawm cov proteolytic cleavage ntawm prepropeptide loj dua. Qhov no prepropeptide yog ib yam khoom ntawm CALC1 noob (CALCA). Calcitonin ua haujlwm zoo li tus antagonist nrog PTH thiab vitamin D3. Kev tso tawm ntawm calcitonin yog txhawb los ntawm kev nce ntawm Ca2+ ions hauv cov ntshav, gastrin, thiab pentagastrin. Calcitonin receptor yog G protein-coupled receptor uas yog nyob rau hauv osteoclasts, ob lub raum, thiab hlwb hlwb. Tsis tas li ntawd, calcitonin assay muaj qhov tseem ceeb ntawm kev kho mob vim nws yog siv los txheeb xyuas cov neeg mob uas muaj cov kab mob nodular thyroid xws li medullary carcinoma ntawm cov thyroid. Nyob rau hauv pharmacology, salmon calcitonin yog siv los kho cov kab mob xws li postmenopausal osteoporosis, hypercalcemia, pob txha metastases, Paget's kab mob, thiab phantom limb mob.
YParathyroid Hormone yog dab tsi?
Parathyroid hormone (PTH) yog ib qho tshuaj peptide uas ua rau cov ntshav qabzib ntau ntawm calcium. Nws yog ib qho tshuaj hormones secreted los ntawm cov hlwb tseem ceeb ntawm cov qog parathyroid, uas tswj cov ntshav calcium concentration los ntawm nws cov nyhuv ntawm cov pob txha, lub raum, thiab txoj hnyuv. PTH feem ntau cuam tshuam rau pob txha kho, uas yog txheej txheem uas cov pob txha pob txha hloov pauv thiab rov tsim dua lub sijhawm.
Daim duab 02: Parathyroid Hormone
PTH yog zais hauv cov lus teb rau cov calcium uas tsis tshua muaj nyob hauv cov ntshav. PTH indirectly nkoos osteoclast kev ua si nyob rau hauv cov pob txha matrix thiaj li yuav tso tawm ntau ionic calcium (Ca2+) mus rau hauv cov ntshav kom elevate lub qes calcium concentration. Ntxiv mus, PTH yog polypeptide muaj 84 amino acids, uas yog ib tug prohormone. Nws yog protein encoded los ntawm PTH noob. Lub molecular loj ntawm PTH yog nyob ib ncig ntawm 9500 Da. Tsis tas li ntawd, muaj ob lub receptors rau PTH: PTH receptor 1 (pob txha thiab lub raum) thiab PTH receptor 2 (central nervous system, pancreas, testes, and placenta).
Dab tsi zoo sib xws ntawm Calcitonin thiab Parathyroid Hormone?
- Calcitonin thiab parathyroid hormone yog ob yam tshuaj peptide.
- Ob leeg cov tshuaj hormones tswj cov ntshav calcium concentration hauv ntau txoj kev.
- Ob leeg cov tshuaj hormones muaj cov receptors tshwj xeeb uas lawv khi.
- Lawv yog cov proteins uas ua los ntawm cov amino acids.
Qhov txawv ntawm Calcitonin thiab Parathyroid Hormone yog dab tsi?
Calcitonin yog peptide hormone uas txo cov ntshav hauv cov calcium, thaum parathyroid hormone yog peptide hormone uas ua rau cov ntshav concentration ntawm calcium. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm calcitonin thiab parathyroid hormone. Tsis tas li ntawd, calcitonin yog cov protein encoded los ntawm CALC1 noob, thaum parathyroid hormone yog protein ntau encoded los ntawm PTH noob.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm calcitonin thiab parathyroid hormone hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Calcitonin vs Parathyroid Hormone
Calcitonin thiab parathyroid hormone yog ob yam tshuaj peptide uas tswj cov ntshav calcium concentration. Calcitonin txo cov ntshav cov ntsiab lus ntawm calcium, thaum cov tshuaj hormones parathyroid tsub kom cov ntshav concentration ntawm calcium. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm calcitonin thiab parathyroid hormone.
