Qhov sib txawv tseem ceeb ntawm HER2 thiab BRCA yog HER2 yog cov noob muaj nyob rau hauv chromosome 17 hauv tib neeg uas muaj kev hloov pauv somatic los ua rau mob qog noj ntshav tsis muaj keeb, thaum BRCA sawv cev rau ob lub noob BRAC1 thiab BRCA2 tam sim no hauv chromosome 17 thiab 13, Raws li txoj cai, qhov kev hloov pauv ntawm cov kab mob ua rau mob qog noj ntshav ntawm lub mis.
mob qog noj ntshav mis yog hom mob qog noj ntshav uas tshwm sim los ntawm cov ntaub so ntswg ntawm lub mis. Nws yog feem ntau pom nyob rau hauv cov poj niam thoob plaws lub ntiaj teb no. Cov cim qhia suav nrog kev hloov pauv ntawm lub mis, pob hauv lub mis, thiab cov pob liab liab ntawm daim tawv nqaij. Kev txhawb nqa loj rau kev paub txog kev mob qog noj ntshav mis thiab kev tshawb fawb nyiaj txiag tau tsim kev pom zoo ntawm kev mob qog noj ntshav mis. Muaj ntau hom mob qog noj ntshav mis vim yog somatic thiab kev hloov pauv ntawm cov noob tseem ceeb. HER2 thiab BRCA yog cov noob uas hloov mus ua mob qog noj ntshav.
HER2 yog dab tsi?
HER2 yog cov noob muaj nyob hauv caj npab ntev ntawm chromosome 17 (17q12) hauv tib neeg. Cov noob no mutates somatically ua rau mob qog noj ntshav tsis muaj keeb. HER2 sawv cev rau human epidermal growth factor gene. Nws yog cov noob uas tsim cov protein nyob rau saum npoo ntawm lub mis. Cov protein no ua rau cov cell loj hlob. Cov noob yog cov hauv paus ntawm cov noob caj noob ces, thiab lawv dhau los ntawm niam txiv mus rau cov xeeb ntxwv. Hauv qee yam mob qog noj ntshav, xws li mob qog noj ntshav mis, HER2 noob hloov pauv thiab ua cov ntawv luam ntxiv ntawm cov noob. Qhov no hu ua over-amplification.
Daim duab 01: HER2
Thaum qhov no tshwm sim, HER2 noob ua rau HER protein ntau dhau lawm, uas ua rau lub mis faib thiab loj hlob sai heev. Cov qog nqaij hlav hauv lub mis uas muaj cov protein ntau HER2 muaj npe hu ua HER2 zoo. Tsis tas li ntawd, cov qog nqaij hlav hauv lub mis uas muaj qib qis ntawm HER2 protein yog hu ua HER tsis zoo. Kwv yees li 20% ntawm cov qog nqaij hlav mis yog HER2 zoo. Kev kuaj mob ntawm tus mob no tuaj yeem ua los ntawm kev kuaj ntshav biopsy, immunohistochemistry, in-situ fluorescence hybridization, thiab HER2 noob hloov pauv. Feem ntau cov poj niam uas muaj HER2 zoo mob qog noj ntshav yuav tau txais cov tshuaj khomob thiab trastuzumab (anti-HER2 antibody) raws li kev kho.
BRCA yog dab tsi?
BRCA1 thiab BRCA2 yog ob lub noob sib txawv uas muaj nyob hauv chromosomes 17 thiab 13, feem. BRCA sawv cev rau cov noob qog nqaij hlav cancer mis. Kev mob qog noj ntshav ntawm lub mis tshwm sim vim yog kev hloov pauv ntawm cov kab mob ntawm ob lub noob no. Cov kev tshawb fawb DNA txuas thawj zaug tau txheeb xyuas cov noob BRAC1 hauv xyoo 1990. Tom qab ntawd, xyoo 1994, BRCA2 noob tau txheeb xyuas. Ob lub noob no yog cov qog nqaij hlav qog nqaij hlav uas tswj kev loj hlob ntawm tes thiab kev tuag ntawm tes. Cov ntawv hloov pauv ntawm BRCA1 lossis BRCA2 noob ua rau muaj kev pheej hmoo rau ntau hom qog noj ntshav. BRCA1 gene mutation ua rau muaj kev pheej hmoo ntawm lub mis, zes qe menyuam, thiab qog nqaij hlav prostate. Ntawm qhov tod tes, BRCA2 cov noob hloov pauv ua rau muaj kev pheej hmoo ntawm lub mis, zes qe menyuam, pancreatic, prostate, mob qog noj ntshav, thiab melanoma.
Daim duab 02: BRCA
Tsuas yog ib feem me me ntawm cov tib neeg (kwv yees li 0.25% ntawm cov pejxeem) nqa cov ntawv hloov pauv ntawm BRCA1 lossis BRCA2 noob. Kev kuaj BRCA gene yog kuaj ntshav txhawm rau txheeb xyuas cov kev hloov pauv hauv BRCA cov noob caj noob ces. FDA pom zoo Olaparib yog ib yam tshuaj uas kho mob cancer mis metastatic nrog ib tug germline BRCA hloov.
Qhov Zoo sib xws ntawm HER2 thiab BRCA yog dab tsi?
- HER2 thiab BRCA yog ob lub noob uas hloov pauv, ua rau mob qog noj ntshav.
- Cov ntawv luam ib txwm ntawm cov noob no tswj kev loj hlob ntawm tes.
- Ob hom HER2 thiab BRCA1 yog nyob hauv chromosome 17 ntawm tib neeg.
- Mutated HER2 thiab BRCA cov noob tuaj yeem ua rau ntau hom qog nqaij hlav dua li mob qog noj ntshav hauv tib neeg.
Qhov txawv ntawm HER2 thiab BRCA yog dab tsi?
HER2 yog cov noob muaj nyob rau hauv chromosomes 17 hauv tib neeg thiab hloov pauv somatically ua rau mob qog noj ntshav ntawm lub mis, thaum BRAC1 thiab BRCA2 (BRCA) yog ob lub noob muaj nyob rau hauv chromosomes 17 thiab 13, raws li kev hloov pauv ntawm cov kab mob, ua rau cov qog nqaij hlav hauv lub mis. mob qog noj ntshav. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm HER2 thiab BRCA. Tsis tas li ntawd, kwv yees li 20% ntawm cov qog nqaij hlav cancer mis yog vim HER2 kev hloov pauv, thaum txog li 5 txog 10% ntawm cov qog nqaij hlav mis yog vim BRCA kev hloov pauv.
Cov infographic hauv qab no teev qhov sib txawv ntawm HER2 thiab BRCA hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – HER2 vs BRCA
mob qog noj ntshav mis yog hom mob qog noj ntshav uas qee lub hlwb ntawm lub mis sib txawv txawv txav los tsim cov qog. Mob qog noj ntshav mis muaj ob qho tib si tau los thiab tsis yog los ntawm qhov ua rau. HER2 thiab BRCA yog cov noob sib txawv uas hloov mus ua mob qog noj ntshav. HER2 tau txais kev hloov pauv ntawm somatic los ua mob qog noj ntshav ntawm lub mis, thaum BRCA cuam tshuam cov kab mob hloov pauv los ua cov qog nqaij hlav hauv lub mis. Yog li, qhov no qhia txog qhov sib txawv ntawm HER2 thiab BRCA.
