Qhov sib txawv tseem ceeb ntawm cisplatin thiab transplatin yog tias cisplatin tsim ntau DNA abduct ntau dua li transplatin.
Cisplatin thiab transplatin yog cov qauv isomers ntawm ib leeg. Cisplatin yog cis isomer ntawm Dichlorodiammineplatinum (II) thaum transplatin yog trans isomer ntawm tib lub tebchaw. Ntawm no, cis isomer muaj cov tshuaj tseem ceeb, tab sis transplatin tsis yog siv ntau.
Cisplatin yog dab tsi?
Cisplatin yog cis isomer ntawm Dichlorodiammineplatinum (II). Nws yog hom tshuaj kws khomob uas peb siv tau los kho mob qog noj ntshav. Qee hom mob qog noj ntshav uas peb tuaj yeem kho nrog cov tshuaj no muaj xws li qog nqaij hlav qog nqaij hlav, qog nqaij hlav zes qe menyuam, mob qog noj ntshav mis, mob ntsws cancer, qog hlwb, thiab lwm yam. Lub npe lag luam ntawm cov tshuaj no yog Platinol. Txoj kev ntawm kev tswj hwm rau cov tshuaj no yog kev tswj hwm txoj hlab ntshav raws li lub sij hawm luv luv infusion hauv ib txwm saline rau kev kho mob malignancies.
Txawm li cas los xij, muaj ntau cov kev mob tshwm sim uas cov neeg mob ntsib thaum siv cov tshuaj no. Qee qhov piv txwv muaj raws li hauv qab no;
- Nephrotoxicity - lub raum puas yog ib qho kev txhawj xeeb loj txog kev siv cisplatin. Thaum tus neeg mob lub raum ua haujlwm tsis zoo, koob tshuaj yuav tsum raug txo. Txawm li cas los xij, kev tso dej txaus tuaj yeem tiv thaiv tus mob no rau qee qhov.
- Neurotoxicity - paj hlwb puas yog lwm qhov kev txhawj xeeb tseem ceeb txog cisplatin. Cov kab mob uas muaj feem cuam tshuam txog paj hlwb muaj xws li pom kev pom thiab hnov lus tsis zoo. Ob qho xwm txheej no tuaj yeem tshwm sim sai tom qab kev kho mob pib
- Ntaus thiab ntuav
- Ototoxicity - tsis hnov lus yog lwm qhov kev mob tshwm sim tseem ceeb ntawm kev kho cisplatin. Qhov tseem ceeb tshaj plaws, tsis muaj kev kho mob sab nraud los tiv thaiv tus mob no.
- Electrolyte cuam tshuam - cisplatin tuaj yeem ua rau hypomagnesemia, hypokalemia, thiab hypocalcemia.
Feem ntau, cisplatin ua haujlwm los ntawm cuam tshuam nrog DNA replication, uas theoretically txhais tau tias cov tshuaj no tuaj yeem ua rau mob qog noj ntshav. Tom qab kev tswj hwm ntawm cov tshuaj, ib qho tshuaj chlorine ion hauv cov tshuaj maj mam hloov los ntawm cov dej molecule, thiab nws ua rau dej ntws. Qhov kev sib cais ntawm cov tshuaj chloride no yog qhov zoo vim tias intercellular chloride ion concentration yog feem ntau tsuas yog 2-3%. Tom qab ntawd, cov dej molecule hauv cov tshuaj no tuaj yeem raug tshem tawm los ntawm nitrogenous bases ntawm DNA, zoo dua guanine. Yog li ntawd, cisplatin crosslinks nrog DNA nyob rau hauv ntau txoj kev.
Dab tsi yog Transplatin?
Transplatin yog trans isomer ntawm Dichlorodiammineplatinum (II). Cov tshuaj formula ntawm cov compound yog trans-PtCl2(NH3)2 Nws tshwm sim ua ib qho daj khoom nrog dej solubility tsawg heev. Txawm li cas los xij, solubility ntawm cov compound hauv DMF hnyav heev.
Txoj tshuaj muaj peev xwm tsim tau los ntawm kev kho mob [Pt(NH3)4]Cl2nrog hydrochloric acid. Ntau qhov kev tshwm sim ntawm cov tshuaj no qhia tau tias muaj kev cuam tshuam. Cov compound maj mam dhau los ua hydrolysis hauv cov kua dej, muab cov sib xyaw ua ke ntawm aqua complex thiab qee lwm cov tshuaj sib txuas. Ntxiv mus, oxidation ntxiv ntawm transplatin muab trans -PtCl4(NH3)2 piv rau cis isomer, cov tshuaj no tsis muaj cov tshuaj tseem ceeb.
Qhov txawv ntawm Cisplatin thiab Transplatin yog dab tsi?
Cisplatin thiab transplatin yog cov qauv isomers ntawm ib leeg. Qhov sib txawv tseem ceeb ntawm cisplatin thiab transplatin yog tias cisplatin tsim ntau DNA abduct ntau dua li transplatin. Thaum muab piv rau ib leeg, cisplatin muaj txiaj ntsig zoo hauv cov tshuaj ua tshuaj tiv thaiv kab mob, tab sis transplatin tsis muaj cov tshuaj tseem ceeb. Ntxiv mus, cisplatin tsis yog dej-soluble thaum transplatin yog dej-soluble mus rau ib qho kev txiav txim siab. Thaum yaj hauv dej, transplatin nkag mus rau hydrolysis.
Hauv qab infographic qhia txog qhov sib txawv ntawm cisplatin thiab transplatin.
Summary – Cisplatin vs Transplatin
Cisplatin thiab transplatin yog cov qauv isomers ntawm ib leeg. Qhov sib txawv tseem ceeb ntawm cisplatin thiab transplatin yog tias cisplatin tsim ntau DNA abduct ntau dua li transplatin. Cisplatin yog ib qho tseem ceeb raws li cov tshuaj tiv thaiv kab mob, thaum transplatin tsis muaj cov tshuaj tseem ceeb.
