Qhov sib txawv tseem ceeb ntawm STAT5A thiab STAT5B yog tias STAT5A yog cov protein hauv tib neeg coded los ntawm STAT5A noob thaum STAT5B yog cov protein hauv tib neeg coded los ntawm STAT5B noob.
Signal transducer thiab activator of transcription (STAT) yog ib tsev neeg ntawm universal transcription yam. Lawv yog cov proteins uas pab cov hlwb kom nkag siab thiab teb rau ib puag ncig kev hloov pauv. Lawv kho cov lus teb ntawm tes rau ntau yam cytokines thiab cov tshuaj hormones. Lawv tsuas yog tswj cov kev qhia ntawm cov noob hauv ntau hom cell. Muaj xya hom STAT proteins. Ntawm lawv, STAT5 yog ib tsev neeg muaj ob lub proteins uas muaj feem cuam tshuam. Lawv yog STAT5A thiab STAT5B hauv tib neeg thiab stat5a thiab stat5b hauv nas. Tib neeg STAT5A thiab STAT5B qhia ntau dua 90% ntawm peptide ib ntus zoo sib xws. Yog li ntawd, lawv cov qauv sib txawv tsuas yog 6 amino acids hauv lawv cov DNA binding domains, 20 amino acids hauv lawv C-termini thiab 18 amino acids hauv lawv N-termini. STAT5 cov proteins tau qhib thaum lub sijhawm qhia ntxov tshaj plaws los ntawm IL-2 tsev neeg ntawm cytokines. Qhov no tso cai rau kev xa tawm sai ntawm cov paib los ntawm daim nyias nyias mus rau lub hauv paus hauv kev txiav txim rau cov noob qhia.
STAT5A yog dab tsi?
STAT5A yog protein ntau hauv tib neeg coded los ntawm cov noob SATA5A. Nws yog ib qho ntawm ob qhov sib txuas ntawm cov proteins ntawm STAT5. STAT5A muaj rau lub membrane domains los yog functional units. Lwm yam tshaj li rau lub luag haujlwm, muaj qee qhov tshwj xeeb amino acids uas pab txhawb rau STAT5A. Nws txawv ntawm STAT5B los ntawm ob peb tus lej ntawm cov amino acids.
Daim duab 01: STAT5A
STAT5A kho cov lus teb ntawm ntau cov ligands xws li IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, thiab cov tshuaj hormones sib txawv, thiab lwm yam. Qhov tsis txaus ntawm STAT5A ua rau ntau yam kab mob xws li mob qog noj ntshav thiab myeloproliferative neoplasm..
STAT5B yog dab tsi?
STAT5B yog qhov thib ob uas cuam tshuam nrog cov protein hauv STAT5 tsev neeg. Nws yog ib qho kev hloov pauv. Nws yog coded los ntawm STAT5B noob nyob rau hauv tib neeg. Cov protein no kho cov teeb liab hloov pauv ntawm ntau lub cell ligands xws li IL2, IL4, CSF1, thiab cov tshuaj hormones sib txawv, thiab lwm yam.
Daim duab 02: STAT5B
Ntxiv mus, STAT5B koom nrog hauv TCR signaling, apoptosis, neeg laus mammary gland kev loj hlob, thiab kev sib deev dimorphism ntawm daim siab gene qhia. STAT5B ua lub luag haujlwm lom neeg hauv cov kab mob ua xua, tiv thaiv kab mob, autoimmunities, mob qog noj ntshav, kab mob hematological, mob loj hlob, thiab kab mob ntsws.
Qhov Zoo sib xws ntawm STAT5A thiab STAT5B yog dab tsi?
- STAT5A thiab STAT5B yog qhov kev hloov pauv thoob ntiaj teb.
- Lawv yog kwv tij ntxaib ntawm cov teeb liab transduction thiab transcriptional activation.
- Lawv yog ob qho tib si monomeric proteins
- Txoj kev tsim qauv, lawv pom cov kab ke peptide zoo sib xws ntau dua 90%.
- Ob leeg cov proteins tuaj yeem khi rau tib lub hom phiaj.
- Lawv kho kom haum cov teeb liab rau qhov dav dav ntawm cytokines thiab tyrosine kinase receptors.
- Lawv tswj kev qhia ntawm lub hom phiaj cov noob nyob rau hauv ib hom cytokine tshwj xeeb.
- Ob leeg STAT5A thiab STAT5B yog qhov tseem ceeb rau kev txhim kho ib txwm muaj ntawm txhua tus kab mob lymphoid.
- Ob tug noob uas code rau STAT5A thiab STAT5B tau sib sau ua ke ntawm 17q11.
- Lawv cov noob yog tswj hwm los ntawm Sp-1 cis-element.
Qhov txawv ntawm STAT5A thiab STAT5B yog dab tsi?
Cov noob STAT5A cov lej rau cov protein STAT5A thaum cov noob STAT5B cov lej rau cov protein STAT5B. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm STAT5A thiab STAT5B. Ntxiv mus, STAT5A mediates cov lus teb ntawm ntau cov ligands ntawm tes, xws li IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, thiab ntau yam kev loj hlob hormones, thaum STAT5B protein mediates lub teeb liab kis tau los ntawm ntau lub cell ligands, xws li IL2, IL4, CSF1, thiab cov tshuaj hormones sib txawv.
Cov hauv qab no qhia txog qhov sib txawv ntawm STAT5A thiab STAT5B hauv daim ntawv teev npe.
Summary – STAT5A vs STAT5B
STAT5A thiab STAT5B yog ob qho tib si cov proteins uas pab hauv kev xa cov teeb liab thiab kev ua kom transcription. STAT5A noob lej rau STAT5A thaum STAT5B noob lej rau STAT5B. Ob lub noob tau muab tso rau ntawm 17q11 thiab lawv tau tswj hwm los ntawm Sp-1 cis-element. Ob leeg cov proteins kho cov lus teb ntawm cytokines thiab tyrosine kinase receptors. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm STAT5A thiab STAT5B.
