Qhov txawv ntawm filgrastim thiab lenograstim yog tias filgrastim yog recombinant methionyl tib neeg G CSF uas tau qhia los ntawm E. coli thaum lenograstim yog glycosylated recombinant tib neeg G CSF uas yog qhia los ntawm Suav hamster zes qe menyuam kab.
Granulocyte colony-stimulating factor (G CSF) yog cov protein uas zais los ntawm ntau lub hlwb xws li endothelial cells, monocytes thiab fibroblasts hauv peb lub cev. Cov noob uas codes rau G CSF muaj nyob rau hauv chromosome 17. G CSF txhawb cov pob txha pob txha los tsim ntau neutrophils, uas yog cov qe ntshav dawb uas tawm tsam cov kab mob. G CSF kuj yog tsim los ntawm recombinant DNA technology nyob rau hauv thiaj li yuav muab rau cov neeg mob uas muaj mob loj congenital los yog mob neutropenia. Filgrastim thiab lenograstim yog ob lub recombinant human granulocyte colony-stimulating yam uas muaj rau kev kho mob siv. Filgrastim yog tsim nyob rau hauv E. coli. Lenograstim yog tau los ntawm Suav hamster zes qe menyuam. Ob leeg filgrastim thiab lenograstim yog cytokine proteins. Lenograstim yog ib tug tag nrho glycosylated molecule thaum filgrastim yog ib tug uas tsis yog-glycosylated molecule.
Filgrastim yog dab tsi?
Filgrastim (r-metHuG-CSF) yog ib tug neeg recombinant G CSF uas yog ib tug kws kho mob siv los kho cov neutrophil tsawg. Nws yog tsim los siv cov kab mob qhia (E. coli) system. Nws yog cytokine protein uas muaj qhov hnyav molecular ntawm 18,800 d altons. Muaj ntau lub npe lag luam xa mus rau cov tshuaj no. Lawv yog Neupogen, Granix, Zarxio thiab Granulocyte-colony-stimulating factor. Qhov tseeb, filgrastim yog cov tshuaj txhawb nqa uas txhawb kev tsim cov granulocytes hauv cov neeg mob uas muaj cov qe ntshav dawb tsawg. Ntxiv mus, filgrastim pab kom paub tab thiab qhib neutrophils. Tsis tas li ntawd, nws txhawb kev tso tawm ntawm neutrophils los ntawm cov pob txha pob txha. Filgrastim ua kom rov qab los ntawm neutrophils los ntawm kev txo cov theem ntawm neutropenic, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob tau txais kev kho mob.
Daim duab 01: Filgrastim
Filgrastim tuaj yeem txhaj lossis infuse rau hauv cov leeg. Feem ntau, cov tshuaj no yuav tsum khaws cia hauv lub tub yees thiab yuav tsum tau tshem tawm ntawm lub tub yees 30 feeb ua ntej txhaj tshuaj. Qhov tseem ceeb tshaj plaws, nws yuav tsum tsis txhob shaken lossis khaws cia nyob rau hauv lub hnub ncaj qha. Qhov koob tshuaj filgrastim txawv ntawm cov tib neeg nyob ntawm qhov siab, qhov hnyav, kev noj qab haus huv lossis lwm yam teeb meem kev noj qab haus huv (ib hom mob qog noj ntshav lossis mob tau kho).
Lenograstim yog dab tsi?
Lenograstim yog (rHuG-CSF) glycosylated recombinant daim ntawv ntawm tib neeg granulocyte colony-stimulating factor. Nws yog ib daim ntawv ntawm cytokine protein tau los ntawm Suav hamster zes qe menyuam hlwb. Yog li ntawd, kev qhia ntawm lenograstim yog ua nyob rau hauv mammalian hlwb, tsis zoo li filgrastim, uas yog ua nyob rau hauv cov kab mob hlwb. Ntxiv mus, tsis zoo li filgrastim, uas yog ib qho aglycosylated molecule, lenograstim yog tag nrho glycosylated molecule.
Daim duab 02: Lenograstim – Granocyte
Lub npe lag luam ntawm lenograstim yog Granocyte. Nws yog ib qho immunostimulator zoo ib yam li filgrastim. Lenograstim yog siv los txo qhov kev pheej hmoo ntawm tus kab mob ua rau tuag taus hauv cov neeg mob neutropenia. Nws yog feem ntau siv nyob rau hauv kev kho mob ntawm mob hnyav neutropenia. Lenograstim kuj tseem pab kho neutrophil hauv cov neeg mob uas hloov cov pob txha pob txha. Ntxiv mus, nws stimulates zus tau tej cov peripheral ntshav qia hlwb rau autologous hloov.
Dab tsi zoo sib xws ntawm Filgrastim thiab Lenograstim?
- Ob leeg filgrastim thiab lenograstim yog cov ntaub ntawv sib txuas ntawm tib neeg granulocyte colony-stimulating yam uas yog kho tau zoo rau tib neeg txoj kev loj hlob.
- Lawv tau muab los ntawm kev txhaj tshuaj ntev ntev los yog subcutaneous infusion lossis txhaj tshuaj.
- Lawv yog ib pawg cytokine ntawm cov proteins uas muaj roj ntsha.
- Ob leeg yog immunostimulators.
Qhov txawv ntawm Filgrastim thiab Lenograstim yog dab tsi?
Filgrastim thiab lenograstim yog ob txoj kev kho mob uas siv rau hauv cov tshuaj tua kab mob uas ua rau neutropenia, ua kom cov neutrophil rov qab los tom qab haematopoietic qia cell transplantation thiab peripheral ntshav qia cell mobilization hauv cov neeg mob qog noj ntshav. Ob leeg yog ib daim ntawv recombinant ntawm G CSF. Filgrastim yog ib qho uas tsis yog-glycosylated molecule uas tau nthuav tawm hauv E. coli thaum lenograstim yog tag nrho glycosylated molecule uas tau qhia nyob rau hauv Suav hamster cell kab (mammalian hlwb). Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm filgrastim thiab lenograstim.
Hauv qab infographic teev ntau qhov sib txawv ntawm filgrastim thiab lenograstim hauv daim ntawv teev npe.
Summary – Filgrastim vs Lenograstim
Filgrastim thiab lenograstim yog ob qho tib si recombinant tib neeg granulocyte colony-stimulating yam. Filgrastim yog tsim nyob rau hauv E. coli qhia tshuab, thiab nws yog ib tug uas tsis yog-glycosylated molecule. Lenograstim yog tsim nyob rau hauv Suav hamster cell kab, thiab nws yog ib tug tag nrho glycosylated molecule. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm filgrastim thiab lenograstim. Ob leeg yog tsim los siv cov thev naus laus zis DNA recombinant, thiab lawv muaj rau kev siv tshuaj kho mob. Lawv tau dav siv los kho neutropenia. Lawv raug muab rau cov neeg mob los ntawm kev txhaj tshuaj ntev ntev los yog kev txhaj tshuaj subcutaneous.
