Qhov sib txawv tseem ceeb ntawm prostaglandins thiab leukotrienes yog tias prostaglandins yog tsim los ntawm txhua hom cell thiab txhua qhov chaw ntawm lub cev uas cuam tshuam nrog kev raug mob thiab mob thaum leukotrienes yog tsim los ntawm leukocytes.
Eicosanoids yog tsev neeg ntawm bioactive lipid mediators. Lawv yog oxygenated 20-carbon fatty acids synthesized los ntawm kev noj zaub mov tseem ceeb fatty acids. Lawv koom nrog kev tswj hwm ntawm array ntawm physiological thiab pathological teb. Tsis tas li ntawd, lawv pom muaj zog inflammatory zog thiab pab nyob rau hauv txoj kev loj hlob thiab kev tswj ntawm immunological thiab inflammatory teb. Prostaglandins thiab leukotrienes yog ob hom eicosanoids muab los ntawm arachidonic acid. Prostaglandins txhim kho cov vascular permeability cuam tshuam ntawm histamine thiab bradykinin thaum leukotrienes mediate leukocyte tsub zuj zuj thaum mob hnyav.
YProstaglandins yog dab tsi?
Prostaglandins yog tsev neeg ntawm 20 carbon fatty acid eicosanoids. Lawv yog synthesized los ntawm arachidonic acid ntawm cyclooxygenase ntawm qhov chaw ntawm cov ntaub so ntswg puas los yog kab mob. Yog li ntawd, lawv yog tsim nyob rau hauv tag nrho cov feem ntau ntawm tes thiab tag nrho cov qhov chaw ntawm lub cev uas cuam tshuam nrog kev raug mob thiab mob. Lawv tau faib thoob plaws hauv lub cev.
Daim duab 01: Prostaglandin
Txawm li cas los xij, prostaglandins yog luv luv. Lawv tawg sai sai. Prostaglandins tswj cov txheej txheem xws li mob, ntshav khiav, ntshav txhaws thiab induction ntawm kev ua haujlwm hauv peb lub cev. Tsis tas li ntawd, prostaglandins tswj cov poj niam cev xeeb tub. Lawv ua haujlwm los ntawm kev ua haujlwm ntawm cov receptors tshwj xeeb.
Leukotrienes yog dab tsi?
Leukotrienes yog lwm pab pawg eicosanoids uas ua raws li tus neeg kho mob inflammatory. Leukocytes xws li mast hlwb, eosinophils, thiab lwm yam. tsim leukotrienes los ntawm oxidation ntawm arachidonic acid. Ib qho enzyme hu ua arachidonate 5-lipoxygenase catalyzes cov txheej txheem synthesis. Kev tsim cov leukotrienes feem ntau yog nrog los ntawm kev tsim cov histamine thiab prostaglandins.
Daim duab 02: Leukotrienes
Muaj ob hom leukotrienes. Thawj pab pawg ntawm leukotrienes ua haujlwm nyob rau hauv cov xwm txheej uas mob yog nyob ntawm neutrophils. Pab pawg thib ob ntawm leukotrienes ua rau eosinophil thiab mast cell-induced bronchoconstriction hauv hawb pob. Zuag qhia tag nrho, leukotrienes yog cov tshuaj tseem ceeb hauv ob qho tib si inflammatory teb thiab ua rau mob hawb pob thiab ua xua.
Dab tsi yog qhov zoo sib xws ntawm Prostaglandins thiab Leukotrienes?
- Prostaglandins thiab leukotrienes yog cov tshuaj kho mob.
- Lawv yog eicosanoids.
- Lawv yog tsim los ntawm arachidonic acid.
- Kev tsim cov leukotrienes feem ntau yog nrog los ntawm kev tsim cov histamine thiab prostaglandins.
- Ob hom kev koom tes hauv kev txhim kho thiab kev tswj hwm ntawm kev tiv thaiv kab mob thiab kab mob.
Qhov txawv ntawm Prostaglandins thiab Leukotrienes yog dab tsi?
Prostaglandins thiab leukotrienes yog ob pawg ntawm eicosanoids. Prostaglandins yog tsim los ntawm yuav luag txhua hom cell ntawm lub cev thaum leukotrienes yog tsim los ntawm leukocytes. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm prostaglandins thiab leukotrienes. Tsis tas li ntawd, prostaglandins yog tsim los ntawm phospholipase A2 / cyclooxygenase txoj hauv kev los ntawm arachidonic acids, thaum leukotrienes yog tsim los ntawm 5-lipoxygenase txoj kev los ntawm arachidonic acid.
Ntxiv mus, ua haujlwm, prostaglandins yog qhov tseem ceeb hauv vasodilation, o thiab kev tswj hwm ntawm kev cog lus ntawm cov leeg nqaij. Hauv qhov sib piv, leukotrienes koom nrog hauv kev mob hawb pob thiab ua xua thiab ua kom muaj kev tiv thaiv kab mob.
Hauv qab infographic qhia txog qhov sib txawv ntawm prostaglandins thiab leukotrienes.
Summary – Prostaglandins vs Leukotrienes
Prostaglandins thiab leukotrienes yog ob ntawm plaub hom eicosanoids, uas yog bioactive lipid mediators. Lawv yog tsim los ntawm 20-carbon polyunsaturated fatty acids hu ua arachidonic acids. Prostaglandins yog tsim los ntawm txhua hom hlwb hauv peb lub cev. Hauv kev sib piv, leukotrienes tsuas yog tsim los ntawm leukocytes. Prostaglandins tuaj yeem nthuav cov hlab ntsha, tuaj yeem tswj kev mob, tuaj yeem ua rau mob thiab ua rau kub taub hau. Leukotrienes pab txhawb rau cov mob xws li mob hawb pob, mob caj dab thiab ua xua. Yog li, qhov no qhia txog qhov sib txawv ntawm prostaglandins thiab leukotrienes.
