Qhov sib txawv tseem ceeb ntawm folinic acid thiab methylfolate yog tias folicic acid yog ib qho metabolically active daim ntawv folate whereas lub methylfolate yog ib tug biologically active daim ntawv ntawm folate.
Ob qho tib si folinic acid thiab methylfolate yog hom tshuaj uas peb siv los kho cov kab mob sib txawv ntawm qib cellular. Lub ntsiab lus ntawm folinic acid yog leucovorin, uas peb tuaj yeem noj los ntawm qhov ncauj, txhaj rau cov leeg lossis cov leeg. Lub ntsiab lus ntawm methylfolate yog Levomefolic acid, uas peb tuaj yeem noj ntawm qhov ncauj, transdermal, subcutaneous txoj kev. Tsis tas li ntawd, qhov sib txawv tseem ceeb ntawm folinic acid thiab methylfolate yog lawv siv. Cov tshuaj folinic acid yog tshuaj los txo cov tshuaj lom ntawm methotrexate thiab pyrimethamine. Txawm li cas los xij, methylfolate yog tshuaj rau DNA kev tsim tawm, lub voj voog cysteine, thiab kev tswj hwm ntawm homocysteine.
Folinic Acid yog dab tsi?
Folinic acid lossis leucovorin yog cov tshuaj uas peb siv los txo cov tshuaj lom ntawm methotrexate thiab pyrimethamine. Nws yog ib daim ntawv metabolically active ntawm folate. Ntawm lwm yam kev siv cov tshuaj no, peb tuaj yeem siv los kho mob qog noj ntshav (yuav tsum siv qhov no nrog 5-fluorouracil). Tsis tas li, nws tuaj yeem kho qhov tsis muaj folate thiab. Txoj kev ntawm kev tswj hwm cov tshuaj no yog qhov ncauj, txhaj tshuaj rau cov leeg, thiab txhaj tshuaj rau cov leeg.
Daim duab 01: Cov qauv tshuaj ntawm Folinic Acid
Cov tshuaj formula ntawm cov khoom xyaw nquag ntawm cov tshuaj no yog C 20H23N7 O7,thiab molar mass yog 473.44 g / mol. Lub melting point ntawm no compound yog 245 ° C thiab nyob rau hauv kub saum toj no melting point, lub compound decomposes. Li no tsis muaj qhov kub hnyiab rau qhov sib xyaw no.
Thaum xav txog cov kev mob tshwm sim ntawm cov tshuaj no, nws suav nrog teeb meem pw tsaug zog, ua xua thiab ua npaws feem ntau. Txawm li cas los xij, kev tswj hwm ntawm txoj hauv kev intrathecal tuaj yeem ua rau muaj kev cuam tshuam loj heev lossis txawm tias tuag. Ntxiv mus, cov folic acid tuaj yeem hloov mus rau methylfolate.
Methylfolate yog dab tsi?
Methylfolate lossis Levomefolic yog cov tshuaj uas peb siv rau kev tsim DNA, lub voj voog cysteine thiab kev tswj hwm ntawm homocysteine. Tsis tas li ntawd, nws yog lub hauv paus, kev ua haujlwm lom neeg ntawm folate. Tsis tas li, cov tshuaj no muaj txiaj ntsig zoo hauv cov tshuaj methylation ntawm homocysteine los tsim methionine thiab tetrahydrofolate. Txoj kev ntawm kev tswj hwm rau cov tshuaj no suav nrog ntawm qhov ncauj, transdermal, subcutaneous txoj kev. Tsis tas li ntawd, cov tshuaj no muaj ntau yam dej soluble thiab yog li, tuaj yeem tawm ntawm lub raum.
Daim duab 02: Cov Qauv Tshuaj ntawm Methylfolate
Saib cov khoom siv tshuaj, cov tshuaj formula ntawm cov khoom xyaw nquag ntawm cov tshuaj no yog C20H25N 7O6,thiab molar mass yog 459.46 g / mol. Xav txog cov kev mob tshwm sim, cov kev mob tshwm sim ntawm cov tshuaj no muaj xws li khaus khaus, mob nqaij, mob pob qij txha, pob txuv, pob khaus thiab lwm yam kev tsis haum tshuaj.
Qhov txawv ntawm Folinic Acid thiab Methylfolate yog dab tsi?
Folinic acid thiab methylfolate yog ob hom folate. Qhov sib txawv tseem ceeb ntawm folinic acid thiab methylfolate yog tias folinic acid yog ib qho metabolically active daim ntawv folate thaum methylfolate yog ib hom tshuaj lom neeg ntawm folate. Tsis tas li ntawd, raws li lwm qhov sib txawv tseem ceeb ntawm folinic acid thiab methylfolate, peb tuaj yeem hais tias kev siv folinic acid yog txo cov tshuaj lom ntawm methotrexate thiab pyrimethamine whereas methylfolate yog tshuaj rau DNA kev tsim tawm, cysteine cycle, thiab kev tswj hwm homocysteine.
Ntxiv mus, txoj hauv kev ntawm kev tswj hwm kuj tuaj yeem sib txawv ntawm ib leeg. Yog li, qhov sib txawv ntawm folic acid thiab methylfolate raws li kev tswj hwm yog tias rau folic acid, nws yog los ntawm lub qhov ncauj, txhaj rau cov leeg lossis cov leeg thaum rau methylfolate nws yog ntawm qhov ncauj, transdermal, subcutaneous txoj kev.
Summary – Folinic Acid vs Methylfolate
Folinic acid thiab methylfolate yog ob hom tshuaj uas peb tuaj yeem siv los kho cov kab mob sib txawv ntawm qib cellular. Hauv cov ntsiab lus, qhov sib txawv tseem ceeb ntawm folinic acid thiab methylfolate yog cov folinic acid yog ib hom metabolically nquag ntawm folate whereas methylfolate yog ib hom tshuaj lom neeg ntawm folate.
