Qhov sib txawv tseem ceeb ntawm cov protein kinase A thiab protein kinase C yog cov protein kinase A yog ib hom protein kinase uas nyob ntawm cyclic AMP, thaum protein kinase C yog ib pawg ntawm cov protein kinases uas teb rau lipid signaling..
Kinase yog ib qho enzyme uas catalyzes hloov ntawm phosphate pab pawg neeg los ntawm high-zog, phosphate-dawb molecules rau tej substrates. Peb hu cov txheej txheem no phosphorylation. Kinases tswj feem ntau ntawm cellular txoj kev, nrog rau cov teeb liab transduction. Protein kinases yog ib hom kinases uas catalyze protein phosphorylation los yog hloov phosphate mus rau cov protein substrate. Cov enzymes tswj kev ua haujlwm lom neeg ntawm cov protein los ntawm phosphorylation ntawm cov amino acids tshwj xeeb nrog phosphate pawg los ntawm ATP. Thaum phosphorylation tshwm sim, cov proteins uas tsis muaj zog hloov mus rau cov protein ntau vim yog qhov hloov pauv hloov pauv. Protein kinase C thiab protein kinase A yog ob hom protein kinase tsev neeg uas muaj nyob rau hauv subfamily: AGC kinase ntawm protein kinases.
YProtein Kinase A yog dab tsi?
YProtein kinase A yog ib hom protein kinase uas nyob ntawm cyclic AMP. Li no, nws tseem hu ua cyclic AMP-dependent protein kinase lossis A kinase. Nws lub luag haujlwm tseem ceeb yog phosphorylate proteins nrog phosphate pawg. Txij li cov protein kinase A yog nyob ntawm cyclic AMP, nws cov haujlwm yog tswj hwm los ntawm cov qib hloov pauv ntawm cyclic AMP hauv cov hlwb. Ntxiv mus, protein kinase A ua raws li qhov kawg effector rau ntau yam tshuaj hormones uas ua haujlwm los ntawm kev sib tw AMP teeb liab. Yog li, qhov enzyme no yog lub luag haujlwm rau tag nrho cov lus teb ntawm tes.
Daim duab 01: Protein Kinase A
Structurally, protein kinase A yog ib tug heterotetramer muaj li ntawm ob subunits: catalytic subunit thiab ib tug tswj subunit. Kev ua haujlwm ntawm cov protein kinase A kuj tuaj yeem txo lossis cuam tshuam los ntawm cov protein kinase inhibitors. Cov inhibitors feem ntau ua raws li pseudosubstrates rau catalytic subunit.
YProtein Kinase C yog dab tsi?
Protein kinase C yog ib tsev neeg ntawm cov protein kinases thiab teb rau lipid signaling. Lub subfamily muaj kaum tsib isozymes hauv tib neeg. Isozymes txawv ntawm tus xa xov thib ob. Protein kinase C muaj ob lub ntsiab lus: lub chaw tswj hwm thiab catalytic domain. Qhov tseeb, protein kinase C yog ib qho kev ua haujlwm ntau ntawm cov protein serine kinase uas koom nrog ntau yam kev ua haujlwm neuronal.
Daim duab 02: Protein Kinase C
Ntxiv mus, Protein kinase C ua raws li lub hauv paus ntawm ntau qhov tseem ceeb ntawm tes taw qhia cascades. Tsis tas li ntawd, cov protein kinase C yog lub luag haujlwm rau kev tswj hwm kev hloov pauv, kho cov kab mob tiv thaiv kab mob, tswj kev loj hlob ntawm tes thiab hloov cov qauv membrane.
Dab tsi zoo sib xws ntawm Protein Kinase A thiab Protein Kinase C?
- Ob leeg protein kinase A thiab protein kinase C yog AGC kinases.
- Yog li, lawv nyob rau ib tsev neeg ntawm cov protein kinases hu ua AGC kinase.
- Lawv ua lub luag haujlwm tseem ceeb hauv ntau lub teeb liab hloov pauv hauv cov kab mob nyob.
- Structurally, lawv muaj ob lub subunits ua tus tswj hwm thiab lub catalytic domain.
- Lawv cov haujlwm tuaj yeem cuam tshuam los ntawm cov protein kinase inhibitors.
Qhov txawv ntawm Protein Kinase A thiab Protein Kinase C yog dab tsi?
Protein kinase A thiab protein kinase C yog ob tsev neeg ntawm cov protein kinases uas yog AGC kinases. Protein kinase A yog ib qho protein kinase uas nyob ntawm cyclic AMP thiab ua qhov kawg effector rau ntau yam tshuaj hormones. Lub caij no, cov protein kinase C yog cov protein kinase uas teb rau lipid signaling. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cov protein kinase A thiab protein kinase C.
Summary – Protein Kinase A vs Protein Kinase C
Protein kinase yog ib qho enzyme uas hloov lwm cov proteins los ntawm kev ntxiv ib pab pawg phosphate rau lawv. Protein kinase A thiab protein kinase C yog ob lub tsev neeg ntawm AGC kinases ntawm cov protein kinases. Protein kinase A yog nyob ntawm cyclic AMP. Hauv qhov sib piv, protein kinase C yog ib hom kinase uas kho cov teeb liab hloov pauv los ntawm hydrolyzing lipids. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cov protein kinase A thiab protein kinase C.
