Qhov sib txawv tseem ceeb ntawm Robertsonian thiab kev hloov pauv sib txuas yog tias Robertsonian translocation yog hais txog kev sib pauv ntawm cov khoom siv caj ces ntawm tsib tus khub acrocentric chromosome, uas ua rau txo qis ntawm tus lej chromosome ib txwm nyob hauv ib lub xovtooj, thaum sib pauv hloov pauv mus rau kev sib pauv hloov pauv. Cov khoom siv caj ces ntawm cov chromosomes uas tsis yog homologous, uas tsis ua rau muaj kev hloov pauv ntawm tus lej chromosome.
Kev hloov pauv caj ces yog qhov tshwm sim ntawm kev sib pauv cov khoom siv caj ces ntawm chromosomes. Vim yog translocation, genetic cov ntaub ntawv rearrange ntawm chromosomes. Qee qhov kev hloov pauv tsis ua rau nce lossis poob. Hauv cov lus yooj yim, kev sib pauv cov khoom siv caj ces tshwm sim yam tsis muaj cov khoom siv caj ces ntxiv lossis ploj lawm. Lawv yog balanced translocations. Nyob rau hauv sib piv, unbalances translocations ua rau tsis sib npaug ntawm cov khoom siv caj ces, ua rau trisomy lossis monosomy ntawm ib ntu chromosome. Li no, nws ua rau ploj lawm lossis ntxiv cov noob hauv chromosomes.
Robertsonian Translocation yog dab tsi?
Robertsonian translocation yog hom chromosomal txawv txav uas tshwm sim vim kev sib pauv ntawm chromosome ntu ntawm acrocentric chromosomes. Yog li, hom chromosomal abnormality no feem ntau tshwm sim nyob rau hauv acrocentric chromosome khub uas suav nrog 13, 14, 15, 21 thiab 22. Hauv hom no, qee qhov chromosome tseem txuas nrog lwm tus. Lawv tuaj yeem pom cytologically thiab tuaj yeem txo tus lej chromosome thaum lub caj npab luv luv vim yog fusion ntawm caj npab ntev ntawm ob acrocentric chromosomes. Yog li ntawd, feem ntau cov neeg uas muaj Robertsonian translocation tsuas muaj 45 chromosomes nyob rau hauv txhua lub hlwb.
Daim duab 01: Robertsonian Translocation
Tus neeg nqa khoom ntawm Robertsonian hloov chaw noj qab haus huv. Txawm li cas los xij, teeb meem yuav tshwm sim hauv lawv cov menyuam. Down syndrome thiab Patau syndrome yog ob qhov xwm txheej zoo li no tshwm sim hauv cov menyuam yaus vim Robertsonian hloov chaw. Ntxiv nrog rau cov tsos mob no, Robertsonian hloov chaw kuj tseem tuaj yeem ua rau muaj teeb meem tsis muaj menyuam, tseem yug menyuam thiab nchuav menyuam.
Kev hloov pauv hloov pauv yog dab tsi?
Kev hloov pauv hloov pauv yog qhov pauv lossis hloov pauv ntawm chromosome ntu ntawm cov chromosomes uas tsis yog homologous. Nyob rau hauv reciprocal translocation, kev sib pauv ntawm chromosome ntu tshwj xeeb tshaj yog tshwm sim ntawm ob chromosomes uas tsis koom rau tib khub ntawm chromosomes. Piv txwv li, ib qho kev hloov pauv sib txawv yuav tshwm sim ntawm chromosomes 1 thiab 19. Txij li thaum cov khoom siv chromosome pauv ntawm ob lub chromosomes uas tsis yog homologous, ob lub chromosomes translocated yog tsim. Tsis tas li ntawd, qhov chaw ntawm centromere thiab qhov ntau thiab tsawg ntawm chromosomes yuav txawv heev vim muaj kev sib hloov pauv.
Daim duab 02: Kev hloov pauv hloov pauv hloov pauv
Nyob rau hauv kev sib npaug sib npaug, tsis muaj qhov pom tseeb ntawm cov khoom siv caj ces. Yog li ntawd, kev sib txuas lus sib txuas tsis yog ib txwm ua rau muaj kab mob. Txawm li cas los xij, nws yuav ua rau muaj teeb meem tsis muaj menyuam thiab nchuav menyuam.
Dab tsi yog qhov zoo sib xws ntawm Robertsonian thiab Kev Hloov Kev Sib Raug Zoo?
- Ob qho tib si Robertsonian thiab kev sib txuas lus sib txuas yog chromosomal abnormalities.
- Lawv tshwm sim los ntawm kev sib pauv cov khoom siv caj ces ntawm chromosomes.
- Ob leeg ua rau nchuav menyuam, teeb meem tsis muaj menyuam, thiab lwm yam.
Dab tsi yog qhov txawv ntawm Robertsonian thiab Reciprocal Translocation?
Robertsonian translocation tshwm sim hauv acrocentric chromosomes thiab ua rau txo tus lej chromosome. Nyob rau hauv sib piv, reciprocal translocation tshwm sim nyob rau hauv nonhomologous chromosomes, thiab nws tsis ua rau txo tus naj npawb ntawm chromosome. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm Robertsonian thiab kev hloov pauv sib txawv. Tsis tas li ntawd, qhov kev hloov pauv sib txawv yog ntau dua li Robertsonian translocation.
Hauv qab infographics qhia ntau qhov kev sib piv ntsig txog qhov sib txawv ntawm Robertsonian thiab kev sib txuas lus sib txuas.
Summary – Robertsonian vs Reciprocal Translocation
Robertsonian translocation thiab reciprocal translocation yog ob hom chromosomal translocations. Robertsonian translocation tshwm sim hauv acrocentric chromosome khub. Ntawm no, genetic cov ntaub ntawv pauv ntawm acrocentric chromosomes, ua rau poob ntawm caj npab luv thiab fusing lub caj npab ntev ua ke. Nyob rau hauv reciprocal translocation, chromosome fragments pauv los yog sib pauv ntawm nonhomologous chromosomes tsim ob translocated chromosomes. Yog li, tsis muaj qhov pom tseeb ntawm cov khoom siv caj ces poob hauv kev hloov pauv hloov pauv. Yog li, qhov no xaus cov ntsiab lus ntawm qhov sib txawv ntawm Robertsonian thiab kev hloov pauv sib txawv.
