Qhov sib txawv tseem ceeb ntawm chaperons thiab chaperonins yog cov chaperones ua ntau yam haujlwm xws li folding thiab degradation ntawm cov protein, pab hauv cov protein sib dhos, thiab lwm yam., whereas lub luag haujlwm tseem ceeb ntawm chaperonins yog los pab hauv folding. ntawm cov protein ntau molecules.
Molecular chaperons lossis chaperones yog cov protein molecules uas pab hauv cov txheej txheem ntawm folding proteins rau hauv cov qauv nyuaj. Yog li ntawd, chaperonins yog ib hom chaperone, uas suav nrog cov proteins uas muaj cua sov. Tawm ntawm txhua hom chaperones, chaperonins yog cov proteins uas tau kawm ntau tshaj plaws vim yog lub luag haujlwm tseem ceeb uas nws ua si thaum lub sijhawm muaj protein ntau. Yog li ntawd, qhov kev txiav txim ntawm chaperones thiab chaperonins tiv thaiv cov irreversible aggregation ntawm cov proteins thiab yog li ua rau lawv functionality. Chaperones thiab chaperonins sib txawv me ntsis raws li kev ua haujlwm ntawm ob lub molecules.
Chaperones yog dab tsi?
Chaperones yog cov proteins uas pab hauv kev sib sau cov protein, folding ntawm cov proteins thiab hauv cov txheej txheem degradation ntawm cov protein. Li no, muaj ntau chav kawm ntawm Molecular Chaperones. Cov chaperons uas khi rau qhov chaw hydrophobic ntawm cov proteins pab txhawb lub folding thiab tiv thaiv irreversible aggregation ntawm cov proteins. Ntxiv mus, chaperones tuaj yeem muab faib ua cov chav kawm sib txawv raws li qhov loj me thiab cellular compartment. Chaperonins yog ib qho ntawm cov chav kawm tseem ceeb tshaj plaws ntawm cov chaperones, uas yog cov protein ua kom sov.
Daim duab 01: Chaperon Action
Tsis tas li ntawd, cov kws kho mob tsim nyog rau cov txheej txheem ntawm cov protein degradation. Thaum cov proteins raug misfolding, cov chaperones koom nrog cov txheej txheem ntawm ubiquitination ua rau kev puas tsuaj ntawm cov protein.
Chaperonins yog dab tsi?
Chaperonin yog ib chav kawm ntawm chaperones uas tshwj xeeb koom nrog hauv folding ntawm cov proteins loj. Lawv muaj cov qauv tshwj xeeb. Chaperonins muaj ob lub nplhaib qauv uas tuaj yeem yog homo - dimeric lossis hetero - dimeric. Ob lub nplhaib no tsim ob lub hauv paus kab noj hniav. Txhua lub subunit muaj ib lub npe uas tuaj yeem khi rau hydrophobic nto ntawm cov protein. Thaum qhov kev sib txuas tshwm sim, cov chaperonins coj qhov kev hloov pauv hauv cov protein. Qhov no tso cai rau qhov tseeb folding ntawm cov protein.
Daim duab 02: Chaperonins
Muaj ob pawg loj ntawm chaperonins uas yog pawg I chaperonins thiab pawg II chaperonins. Pab pawg I chaperonins yog prokaryotic thiab feem ntau suav nrog cov kab mob kub nyhiab cov proteins xws li Hsp60 thiab prokaryotic GroEL. Pawg II chaperonins suav nrog Archean thiab eukaryotic chaperonins. Qee pawg II chaperonins yog T-complex-txog polypeptide thiab GroES.
Dab tsi yog qhov zoo sib xws ntawm Chaperones thiab Chaperonins?
- Chaperones thiab Chaperonins yog cov proteins.
- Lawv feem ntau koom nrog hauv cov protein folding.
- Ob leeg khi rau thaj tsam hydrophobic ntawm cov protein.
- Lawv tuaj yeem ua ke hauv vitro thiab tuaj yeem siv ntau yam kev tshawb fawb ntsig txog protein misfolding.
Qhov txawv ntawm Chaperones thiab Chaperonins yog dab tsi?
Chaperones yog cov protein uas koom nrog hauv cov protein folding, degradation thiab sib dhos. Yog li, muaj ob peb subclasses ntawm chaperones raws li mechanism ntawm kev txiav txim. Qee tus koom nrog hauv cov protein folding thaum qee qhov koom nrog hauv kev solubilization ntawm cov proteins sib xyaw. Ntawm qhov tod tes, chaperonins yog ib hom chaperones, uas tshwj xeeb koom nrog hauv cov protein ntau folding. Qhov no yog qhov sib txawv tseem ceeb ntawm chaperons thiab chaperonins. Ntxiv mus, muaj ob pawg ntawm chaperonins; pab pawg I chaperonins thiab pab pawg II chaperonins.
Cov hauv qab no qhia txog qhov sib txawv ntawm cov chaperons thiab chaperonins hauv daim ntawv tabular.
Summary – Chaperones vs Chaperonins
Chaperones yog ib chav dav dav ntawm biomolecules, uas yog cov proteins. Lawv pab nyob rau hauv protein folding, degradation thiab protein los ua ke. Chaperonins yog ib chav kawm ntawm chaperones uas tshwj xeeb ua haujlwm hauv cov protein ntau folding. Yog li, qhov sib txawv tseem ceeb ntawm chaperons thiab chaperonins yog nyob ntawm kev ua haujlwm ntawm ob lub proteins. Lawv kuj txawv ntawm cov qauv. Cov chaperones sib txawv hauv cov qauv whereas cov chaperonins muaj ob lub suab tshwj xeeb.
