Y Collagen vs Elastin
Cov ntaub so ntswg sib txuas yog qhov tseem ceeb rau kev khi thiab txuas lwm cov ntaub so ntswg hauv lub cev. Lawv kuj muab lub zog, kev txhawb nqa, thiab zoo rau cov ntaub so ntswg. Cov ntaub so ntswg sib txuas yog ib qho system uas cov hlwb tau tawg mus thoob plaws hauv cov kab mob extracellular. Ntxiv nrog rau cov hlwb, cov fibers tsis soluble protein kuj tau muab tso rau hauv matrix. Lub matrix yog hu ua cov khoom hauv av. Cov ntaub so ntswg yog dav faib nyob rau hauv lub cev, matrix pob txha, tendons thiab ligaments, thiab pob txha mos. Cov ntaub so ntswg sib txuas muaj plaub yam ntaub so ntswg, collagen, elastin, proteoglycans, thiab glycoproteins.
Source: Ruth Lawson, Otago Polytechnic, en.wikibooks
YCollagen
Collagen yog cov protein ntau tshaj plaws pom hauv cov ntaub so ntswg sib txuas. Nws muab lub zog tensile zoo thiab tuav cov hlwb ua ke. Tsis tas li ntawd, nws pab kho cov hlwb, yog li tso cai rau kev loj hlob thiab sib txawv ntawm cov hlwb. Tropocollagen yog lub hauv paus txheej txheem ntawm collagen uas muaj α- chains. Txhua α-chain yog tsim los ntawm peb polypeptidechains twisting ib leeg nyob rau hauv ib tug triple helix los ua ib txoj hlua zoo li cov qauv. Muaj hydrogen bonds ntawm cov chains polypeptide los tuav lawv kom nruj. Txhua ntawm cov saw polypeptide no muaj qhov sib npaug ntev thiab muaj txog 1000 amino acidsresidues. Ntau qhov sib xyaw ua ke ntawm peb zaug ntawm polypeptides hauv α-chains ua rau ntau hom collagen hauv tib neeg cov ntaub so ntswg sib txuas (19 hom collagen tau txheeb xyuas txog tam sim no). Feem ntau ntau hom collagen raug faib rau hauv daim tawv nqaij, leeg, pob txha, pob txha, pob txha pob txha, pob txha mos, intervertebral disk, fetal tawv nqaij, kab mob plawv, placentathiab lwm yam. siab tensile zog hauv collagen. Muaj peb hom inter lossis intramolecular cross-links koom nrog txhawm rau txhim kho cov collagen fibers; Lawv yog aldol condensation, Schiff puag, thiab lysinonorleucine.
Source: wikicommons
Elastin Yaj
Elastin yog tsim los ntawm cov subunit hu ua tropoelastin, uas muaj txog 800 amino acid residues. Kev sib txuas ntawm elastin yog qhov nyuaj dua li cov collagens. Desmosine yog hom loj ntawm cov kab sib txuas uas pom hauv elastin. Lawv yog tsim los ntawm condensation ntawm allysine residues nrog lysine. Elastin feem ntau tshwm sim nrog collagen hauv cov ntaub so ntswg. Nws yog cov roj hmab zoo li cov protein kom nws tuaj yeem ncav cuag li ob peb zaug lawv qhov ntev thiab rov qab mus rau lawv cov qauv qub thiab ntev thaum qhov nro tawm. Vim yog cov cuab yeej no, nws pom muaj ntau nyob rau hauv cov ntaub so ntswg txuam nrog ntsws, cov hlab ntsha thiab ligaments, uas undergo loj expansions. Tsis tas li ntawd, lawv kuj pom muaj nyob rau hauv cov chaw xws li daim tawv nqaij, pob txha pob txha thiab ob peb lwm cov ntaub so ntswg me me.
Qhov txawv ntawm Collagen thiab Elastin yog dab tsi?
• Tsuas muaj ib hom noob caj noob ces ntawm elastin, whereas muaj ntau ntau yam caj ces ntawm collagen.
• Elastin muaj peev xwm txaus rau ncab thiab tom qab kom rov qab thaum collagen tsis muaj peev xwm ncab.
• Collagen tus qauv tseem ceeb tau rov ua dua (Gly-X-Y) ib ntus whereas, hauv elastin, tsis muaj qhov rov ua dua (Gly-X-Y) sequences.
• Sib piv rau collagen, tsis muaj kev tsim ntawm triple helix hauv elastin.
• Hydroxylysine muaj nyob rau hauv collagen, whereas nws tsis muaj nyob rau hauv elastin.
• Glycosylated hydroxylysine muaj nyob rau hauv collagen, whereas nws tsis muaj nyob rau hauv elastin.
• Cov kab sib txuas loj tsim hauv collagen yog intramolecular aldol cross-links, whereas cov hauv elastin yog intramolecular desmosine cross-links.
