LMWH vs Heparin
LMWH thiab Heparin yog ob qho tib si anticoagulants. Coagulation txhais tau tias tsim cov ntshav txhaws los tiv thaiv cov ntshav poob vim los ntshav ntau dhau. Thaum coagulation tshwm sim hauv cov xwm txheej tsis xav tau thiab qhov chaw hauv peb lub cev (thrombosis) nws yog qhov txaus ntshai heev vim nws tuaj yeem hloov lossis txo cov ntshav mus rau hauv nruab nrog cev thiab tseem ua rau tuag taus. Qhov no tshwm sim thaum soluble protein fibrinogen hloov mus rau fibrin, ib daim ntawv tsis-soluble, thiab nws tsim cov hlab ntsha nrog platelets. Anticoagulants yog siv los inhibit cov txheej txheem no nyob rau hauv cov xwm txheej uas muaj kev pheej hmoo siab xws li lub sijhawm ntev immobilization thiab phais.
LMWH
LMWH - Tsawg Molecular Nyhav Heparin raws li lub npe txhais tau tias yog ib pawg ntawm heparins nrog qhov hnyav molecular. Qhov no tsis yog li cas heparin tshwm sim hauv peb lub cev. LMWH yog tsim los ntawm extracting heparin thiab ces fractionating nws los ntawm txoj kev xws li oxidative depolymerisation, alkaline beta-eliminative cleavage, deaminative cleavage thiab lwm yam.
Los ntawm txhais LMWH muaj heparin ntsev / polysaccharide chains nrog qhov hnyav nruab nrab ntawm 8000 Da. Tsawg kawg, 60% ntawm heparin molecules hauv LMWH hnyav dua 8000Da. Qee cov LMWH heparins muaj nyob rau hauv kev ua lag luam yog Bemiparin, Certoprin, D alteparin thiab lwm yam. Anticoagulant nyhuv yog siab LMWH. Nws yog muab raws li kev txhaj tshuaj subcutaneous. Cov txheej txheem ntawm kev txiav txim yog khi rau Antithrombin thiab nce inhibition ntawm thrombin uas ua rau coagulation thiab anti-factor hu ua Xa. Kev tshuaj xyuas cov teebmeem ntawm LMWH yog ua los ntawm kev ntsuas kev tiv thaiv Xa kev ua haujlwm. Yog tias LMWH muab rau tus neeg mob hnyav hnyav (siab / qis) lossis tus neeg mob lub raum tsis ua haujlwm, kev saib xyuas kom zoo yog qhov yuav tsum tau ua.
Heparin
Heparin tseem hu ua unfractionated heparin yog ua los ntawm polysaccharide chains. Lawv qhov hnyav li ntawm 5000 Da rau ntau tshaj 40000 Da. Qhov no yog li cas heparin ib txwm tshwm sim hauv peb lub cev. Rau kev siv tshuaj heparin yog muab rho tawm los ntawm bovine ntsws los yog porcine hnyuv. Nws yog muab raws li kev txhaj tshuaj intravenous nyob rau hauv ib koob ntau tshaj LMWH.
Heparin yuav tsum tsis txhob siv yog tias ib tus neeg tsis haum lossis muaj ntshav siab, kab mob kab mob hauv lub plawv, hemophilia, kab mob siab, ntshav los ntshav, lossis txawm tias lub caij nyoog poj niam. Tib yam siv rau LMWH. Nws tuaj yeem muaj kev phiv xws li loog, ua tsis taus pa, mob hauv siab, ua daus no, tawv nqaij liab, liab ntawm ob txhais ceg thiab ntau ntxiv thaum noj heparin lossis LMWH. Tab sis cov kev mob tshwm sim yog siab heparin tshaj LMWH. Qee cov tshuaj xws li tshuaj aspirin, ibuprofen lossis cov tshuaj uas tsis yog-steroidal anti-inflammatory yuav tsum tsis txhob siv thaum noj heparin lossis LMWH vim tias lawv nyiam los ntshav.
LMWH vs Heparin
• LMWH polysaccharide chains muaj qhov hnyav molecular dua li heparin.
• LMWH yog tsim los ntawm fractionating heparin, tab sis heparin yog siv raws li nws yog tom qab rho tawm.
• LMWH yog muab raws li kev txhaj tshuaj subcutaneous, tab sis heparin yog muab raws li kev txhaj tshuaj intravenous thiab koob tshuaj siab.
• Kev Ua Haujlwm ntawm LMWH yog ua los ntawm kev saib xyuas kev tiv thaiv kev ua haujlwm Xa, tab sis kev ua haujlwm heparin raug saib xyuas los ntawm APTT coagulation parameter.
• Txoj kev pheej hmoo los ntshav qis qis hauv LMWH dua li hauv heparin.
• LMWH muaj kev pheej hmoo ntawm osteoporosis tsawg dua heparin thaum siv mus ntev.
• LMWH muaj kev phiv tsawg dua li heparin.
