Qhov sib txawv tseem ceeb ntawm nicotinamide riboside thiab nicotinamide mononucleotide yog nicotinamide riboside yog pyridine nucleoside uas zoo ib yam li vitamin B3,thaum nicotinamide mononucleotide yog nucleotide derived, nicotinamide, nicotinamide riboside, thiab niacin.
Nicotinamide riboside thiab nicotinamide mononucleotide yog ob qho khoom ua ntej molecules rau kev sib txuas ntawm nicotinamide adenine dinucleotide (NAD+). Nws yog ib qho tseem ceeb heev rau lub cev metabolism. NAD+ qib txo qis thaum laus. Nrog rau kev kho dua tshiab ntawm NAD+ qib hauv lub cev, nws pom tias tsiaj tuaj yeem ncua lawv txoj sia thiab txhawb kev noj qab haus huv.
Nicotinamide Riboside yog dab tsi?
Nicotinamide riboside (NR) yog pyridine nucleoside uas zoo ib yam li vitamin B 3. Nws ua haujlwm ua ntej rau nicotinamide adenine dinucleotide (NAD +). Qhov hnyav molecular ntawm nicotinamide riboside yog 255.25 g / mol. Nws yog thawj zaug piav nyob rau hauv 1944 raws li ib tug loj hlob yam (factor V) rau Hemophilus influenzae kab mob, uas nyob thiab nyob ntawm cov ntshav. Vim nws zoo sib xws rau vitamin B3, nws yog categorized nyob rau hauv tsev neeg ntawm vitamin B3. Cov tsev neeg no kuj muaj niacin thiab niacinamide. Nicotinamide riboside muaj nyob rau hauv txiv hmab txiv ntoo, zaub, nqaij, thiab mis nyuj. Hauv lub cev, nws hloov mus rau hauv cov tshuaj tseem ceeb hu ua NAD +. NAD + tseem ceeb heev rau ntau cov txheej txheem hauv tib neeg lub cev. NAD + qib qis tuaj yeem ua rau muaj teeb meem kev noj qab haus huv ntau. Noj nicotinamide riboside tuaj yeem nce qib ntawm NAD + hauv tib neeg lub cev.
Daim duab 01: Nicotinamide Riboside
Tib neeg ib txwm siv nicotinamide riboside los tiv thaiv kev laus thiab kho cov roj cholesterol siab, ntshav siab, Alzheimer's kab mob, rog rog, thiab rau ntau lub hom phiaj. Nicotinamide riboside feem ntau yog noj hauv qhov ncauj. Cov kev mob tshwm sim ntawm kev noj tshuaj ntau dhau ntawm nicotinamide riboside tuaj yeem suav nrog xeev siab, tsam plab, thiab teeb meem ntawm daim tawv nqaij xws li khaus thiab tawm hws.
Nicotinamide Mononucleotide yog dab tsi?
Nicotinamide mononucleotide (NMN) yog nucleotide muab los ntawm ribose, nicotinamide, nicotinamide riboside, thiab niacin. Tib neeg ib txwm muaj cov enzymes uas tuaj yeem siv NMN los tsim NADH (nicotinamide adenine dinucleotide). Hauv cov nas, NMN tuaj yeem nkag mus rau hauv cov hnyuv me thiab hloov mus rau NAD + los ntawm Slc12a8 transporter. NMN yog ib txwm muaj nyob rau hauv txiv hmab txiv ntoo thiab zaub xws li edamame, broccoli, zaub qhwv, dib, thiab avocado. Raws li NADH yog ib qho cofactor rau cov txheej txheem hauv mitochondria thiab rau Sirtuins (SIRTs) thiab poly (ADP-ribose) polymerases (PARPs), NMN tau lees tias yuav muaj peev xwm tiv thaiv kab mob thiab tiv thaiv kev laus. Cov kev tshawb fawb tsis ntev los no tau pom tias NMN txhim kho cov leeg nqaij insulin rhiab heev hauv cov poj niam uas mob ntshav qab zib mellitus thiab txhim kho lub peev xwm aerobic hauv cov neeg nyiam ua haujlwm. Txawm li cas los xij, kev noj ntau dhau ntawm NMN tuaj yeem ua rau muaj kev cuam tshuam rau cov kabmob xws li lub raum, daim siab, pancreatic β-hlwb, thiab cov hlwb hauv cov ntshav thiab tuaj yeem ua rau xeev siab, plab, tsis xis nyob, thiab mob taub hau.
Daim duab 02: Nicotinamide Mononucleotide
Cov qauv molecular ntawm NMN thiab NR yog kwv yees tib yam. Txawm li cas los xij, lawv txawv vim tias NMN muaj cov pab pawg phosphate ntxiv, ua rau nws loj dua molecule. Tsis tas li ntawd, ob qho tib si NR thiab NMN tuaj yeem degraded los ntawm enzymes xws li CD38. Tab sis qhov enzyme no tuaj yeem cuam tshuam los ntawm cov tebchaw xws li CD38-IN-78c.
Dab tsi zoo sib xws ntawm Nicotinamide Riboside thiab Nicotinamide Mononucleotide?
- Nicotinamide riboside thiab nicotinamide mononucleotide yog ob qho khoom ua ntej molecules rau kev sib txuas ntawm nicotinamide adenine dinucleotide.
- Ob leeg pom muaj nyob hauv txiv hmab txiv ntoo thiab zaub.
- Lawv tuaj yeem siv tau los ua cov tshuaj ntxiv los txhim kho qib ntawm NAD + hauv tib neeg lub cev.
- Ob leeg NR thiab NMN tuaj yeem degraded los ntawm enzymes xws li CD38.
- Cov molecules no tuaj yeem ua rau muaj kev phiv hauv tib neeg lub cev vim kev noj ntau dhau.
Qhov txawv ntawm Nicotinamide Riboside thiab Nicotinamide Mononucleotide yog dab tsi?
Nicotinamide riboside yog pyridine nucleoside uas zoo ib yam li cov vitamin B 3,thaum nicotinamide mononucleotide yog nucleotide muab los ntawm ribose, nicotinamide, nicotinamide riboside, thiab niacin. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm nicotinamide riboside thiab nicotinamide mononucleotide. Tsis tas li ntawd, nicotinamide riboside yog cov molecule me me, thaum nicotinamide mononucleotide yog cov molecule loj dua nrog cov phosphate pawg.
Cov hauv qab no qhia txog qhov sib txawv ntawm nicotinamide riboside thiab nicotinamide mononucleotide hauv daim ntawv qhia rau kev sib piv ntawm ib sab.
Summary – Nicotinamide Riboside vs Nicotinamide Mononucleotide
Nicotinamide riboside thiab nicotinamide mononucleotide yog ob lub precursor molecules rau synthesis ntawm nicotinamide adenine dinucleotide. NAD + tseem ceeb heev rau cov metabolism hauv tib neeg lub cev. Nicotinamide riboside yog pyridine nucleoside uas zoo ib yam li vitamin B 3. Tsis zoo li NMN, NA tsis muaj phosphate pawg. Nicotinamide mononucleotide yog nucleotide muab los ntawm ribose, nicotinamide, nicotinamide riboside, thiab niacin. Yog li, qhov no qhia txog qhov sib txawv ntawm nicotinamide riboside thiab nicotinamide mononucleotide.
