Qhov sib txawv tseem ceeb ntawm NNRTI thiab NRTI yog tias NNRTI ua haujlwm los ntawm kev tsis sib tw tiv thaiv kev thim rov qab ntawm tus kab mob HIV thaum NRTI ua haujlwm los ntawm kev sib tw tiv thaiv kev thim rov qab ntawm tus kab mob HIV.
NNRTI (non-nucleoside thim rov qab transcriptase inhibitor) thiab NRTI (nucleoside thim rov qab transcriptase inhibitor) yog ob chav kawm ntawm cov tshuaj tiv thaiv kab mob. Lawv yog siv rau kev kho mob ntawm AIDS (tau txais lub cev tsis muaj zog). Ob leeg NNRTI thiab NRTI cuam tshuam nrog cov txheej txheem ntawm RNA rau DNA thim rov qab ntawm tus kab mob. Txawm li cas los xij, lawv cov txheej txheem sib txawv kiag li.
NNRTI yog dab tsi?
Non-nucleoside thim rov qab transcriptase inhibitor (NNRTI) yog ib chav kawm ntawm cov tshuaj tiv thaiv kab mob siv rau kev kho mob AIDS. NNRII ua haujlwm los ntawm kev sib tw tsis sib tw inhibiting qhov rov qab transcriptase ntawm tus kab mob HIV. Cov tshuaj tiv thaiv kab mob HIV yog cov chav kawm ntawm cov tshuaj HIV. NNRTI khi rau thiab thaiv cov kab mob HIV rov qab transcriptase enzyme. HIV siv rov qab transcriptase los hloov nws RNA rau DNA. Thaiv rov qab transcriptase thiab thim rov qab transcription tiv thaiv HIV los ntawm replicating.
Figure 01: NNRTI
Lub luag haujlwm ntawm kev ua ntawm chav kawm tshuaj no txawv kiag li ntawm lwm chav kawm tshuaj tiv thaiv kab mob. NNRTI cov tshuaj khi ncaj qha rau HIV thim rov qab transcriptase ntawm qhov chaw hydrophobic chaw deb ntawm lub enzyme qhov chaw ua haujlwm los tsim cov kev hloov pauv uas tiv thaiv substrate khi ntawm ib qho enzyme. Lawv muaj cov tshuaj tiv thaiv kab mob ntau dua li cov nucleoside analogue inhibitors thiab tau txais txiaj ntsig zoo dua. Tsis tas li ntawd, cov tshuaj tiv thaiv rau cov chav kawm tshuaj no tshwm sim los ntawm ib qho kev hloov pauv hauv qhov rov qab transcriptase enzyme, uas txo cov kev sib txuas ntawm cov tshuaj mus rau qhov chaw hydrophobic binding. Lawv muaj txiaj ntsig zoo thaum lawv tau siv ua ke nrog tsawg kawg ob yam tshuaj tiv thaiv kab mob.
NNRTIs yog chav kawm thib peb ntawm cov tshuaj tiv thaiv kab mob uas tau tsim. Cov chav kawm ntawm cov tshuaj no tau piav qhia thawj zaug ntawm Rega Institute for Medical Research (Belgium). Tsis tas li ntawd, qee qhov piv txwv ntawm NNRTIs suav nrog Efavirenz, Nevirapine, Delavirdine, Etravirine, Rilpivirine, thiab Doravirine.
NRTI yog dab tsi?
Nucleoside thim rov qab transcriptase inhibitor (NRTI) yog ib chav kawm ntawm cov tshuaj tiv thaiv kab mob siv rau kev kho mob AIDS. Nws kuj ua haujlwm los ntawm kev sib tw inhibiting qhov rov qab transcriptase ntawm tus kab mob HIV. Nws yog thawj chav kawm ntawm cov tshuaj tiv thaiv kab mob tsim. NRTI cov chav kawm tshuaj ua haujlwm sib txawv, tab sis ib txoj hauv kev tseem ceeb yog kev sib tw nrog kev rov qab transcriptase rau lawv cov kev cuam tshuam nrog cov khoom siv caj ces HIV. Cov tshuaj no muaj cov qauv nucleoside thiab nyob ntawm phosphorylation rau kev ua ub no. Muaj ob hom kab mob HIV: HIV-1 thiab HIV-2. NRTIs muaj txiaj ntsig zoo rau ob hom HIV-1 thiab HIV-2.
Figure 02: NRTI
Muaj ntau yam FDA pom zoo NRTIs. Lawv suav nrog Abacavir, Emtricitabine, Lamivudine, Tenofovir alafenamide, Tenofovir disoproxil fumarate, thiab Zidovudine. Feem ntau cov neeg uas muaj tus kab mob HIV siv ntau tshaj ib NRTI ib zaug. Tsis tas li ntawd, NRTIs tuaj yeem ua rau muaj kev puas tsuaj mitochondrial, uas ua rau muaj ntau yam xwm txheej tsis zoo xws li cov tsos mob lactic acidosis.
NNRTI thiab NRTI yog dab tsi?
- NNRTI thiab NRTI yog ob chav kawm ntawm cov tshuaj tiv thaiv kab mob siv rau kev kho mob AIDS.
- NNRTI thiab NRTI cuam tshuam nrog cov txheej txheem ntawm RNA rau DNA thim rov qab.
- Ob leeg yog cov chav kawm siv tshuaj tiv thaiv kab mob HIV-1.
NNRTI thiab NRTI qhov txawv yog dab tsi?
NNRTI yog ib chav kawm ntawm cov tshuaj tiv thaiv kab mob siv rau kev kho mob AIDS thiab ua haujlwm los ntawm kev tsis sib tw tiv thaiv kev thim rov qab ntawm tus kab mob HIV, thaum NRTI yog ib chav kawm ntawm cov tshuaj tiv thaiv kab mob siv rau kev kho mob AIDS thiab ua haujlwm los ntawm kev sib tw. inhibiting qhov rov qab transcriptase ntawm tus kab mob HIV. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm NNRTI thiab NRTI. Tsis tas li ntawd, NNRTI muaj kev tiv thaiv kab mob ntau dua thiab tiv taus zoo dua NRTI.
Cov hauv qab no qhia txog qhov sib txawv ntawm NNRTI thiab NRTI hauv daim ntawv teev npe rau kev sib piv ntawm ib sab.
Summary – NNRTI vs NRTI
NNRTI thiab NRTI yog ob chav tshuaj tiv thaiv kab mob. NNRTI ua haujlwm los ntawm kev tsis sib tw inhibiting qhov rov qab transcriptase ntawm tus kab mob HIV, thaum NRTI ua haujlwm los ntawm kev sib tw inhibiting rov qab transcriptase ntawm tus kab mob HIV. Yog li, qhov no yog qhov txawv ntawm NNRTI thiab NRTI.
