Qhov sib txawv tseem ceeb ntawm cyclosporine thiab cephalosporin yog tias cyclosporine yog tshuaj tiv thaiv kab mob keeb kwm los ntawm fungus Tolypocldium infatum thaum cephalosporin yog β-lactam tshuaj tua kab mob Ameslikas tau los ntawm cov kab mob Acremonium.
Qee cov fungi tsim cov metabolites uas yog tshuaj tseem ceeb. Lawv kuj tuaj yeem raug ntxias los tsim cov metabolites los ntawm biotechnology nrog lub hom phiaj ntawm kev tsim tshuaj. Txawm hais tias cov khoom siv fungi tau siv rau hauv cov tshuaj ib txwm siv ntev dhau los, lub peev xwm los rho tawm cov khoom xyaw muaj txiaj ntsig los ntawm cov kab mob fungi pib nrog kev tshawb pom ntawm penicillin los ntawm Alexander Fleming hauv xyoo 1928. Cov kab mob fungal tau tsim ua tiav rau hauv cov tshuaj lossis hauv kev tshawb fawb suav nrog tshuaj tua kab mob, tshuaj tiv thaiv kab mob, cov roj cholesterol, thiab ergosterol synthesis inhibitors, tshuaj psychotropic, tshuaj tiv thaiv kab mob, thiab fungicides. Cyclosporine thiab cephalosporin yog ob hom active compounds muab rho tawm los ntawm cov tshuaj fungi.
YCyclosporine yog dab tsi?
Cyclosporine yog ib qho tshuaj tiv thaiv kab mob uas tau tsim los ntawm cov kab mob Tolypocldium infatum. Nws yog calcineurin inhibitor. Cyclosporine yog xav kom khi rau cytosolic protein cyclophilin ntawm immunocompetent lymphocytes zoo li T lymphocytes. Qhov no cyclosporine-cyclophilin complex inhibits phosphatase calcineurin, uas nyob rau hauv ib txwm muaj xwm txheej induces tus txheej txheem transcription ntawm interleukin-2. Ntxiv mus, cyclosporine kuj inhibits lymphokine ntau lawm thiab interleukin tso, uas ua rau txo qis kev ua haujlwm ntawm effector T hlwb. Nws yog ib yam khoom ntuj tsim. Feem ntau, nws yog noj los ntawm qhov ncauj los yog txhaj rau hauv cov hlab ntsha. Cyclosporine tuaj yeem siv rau kev kho mob rheumatoid mob caj dab, psoriasis, Crohn's kab mob, nephritic syndrome, thiab hloov khoom nruab nrog cev los tiv thaiv kev tsis lees paub. Tsis tas li ntawd, cyclosporine kuj tseem siv los ua qhov muag tee rau qhov muag qhuav, hu ua keratoconjunctivitis sicca.
Daim duab 01: Cyclosporine
Cov kev mob tshwm sim ntawm cyclosporine muaj xws li ntshav siab, mob taub hau, teeb meem raum, nce plaub hau, thiab ntuav. Lwm cov kev mob tshwm sim hnyav tuaj yeem suav nrog kev pheej hmoo kis mob, teeb meem hauv siab, thiab muaj kev pheej hmoo ntawm lymphoma. Tsis tas li ntawd, cyclosporine yog nyob rau hauv World He alth Organization's List of Essential Medicines.
Cephalosporin yog dab tsi?
Cephalosporin yog tshuaj tua kab mob β-lactam Ameslikas muab los ntawm cov kab mob Acremonium. Ua ke nrog cephamycins, cephalosporins ua ib pawg ntawm β-lactam tshuaj tua kab mob hu ua cephems. Cephalosporins tau pom thawj zaug hauv xyoo 1945 thiab tau muag thawj zaug hauv xyoo 1964. Thawj zaug, aerobic pwm yielding cephalosporin C tau pom hauv hiav txwv ze Su Siccu hauv Sardinia los ntawm Italian kws tshuaj Giuseppe Brotzu xyoo 1945.
Daim duab 02: Cephalosporin
thawj tiam cephalosporins yog cov nquag tawm tsam cov kab mob Gram-zoo li Staphylococcus thiab Streptococcus. Yog li ntawd, lawv tuaj yeem siv rau kev kho mob ntawm daim tawv nqaij thiab cov ntaub so ntswg mos. Ntawm qhov tod tes, cephalosporins ntawm ntau tiam neeg tau nce kev ua haujlwm tawm tsam Gram-negative kab mob nrog txo kev ua haujlwm tiv thaiv kab mob Gram-zoo. Cephalosporins ntawm ntau tiam neeg yog siv rau kev kho mob ntawm bronchitis, pob ntseg kab mob, sinus kab mob, UTIs, gonorrhoea, meningitis, thiab sepsis. Tsis tas li ntawd, cov kev mob tshwm sim ntawm cephalosporins muaj xws li mob plab, xeev siab, ntuav, raws plab, kab mob poov xab, kiv taub hau, ntshav txawv txav, thiab pob khaus lossis khaus.
Dab tsi yog qhov zoo sib xws ntawm Cyclosporine thiab Cephalosporin?
- Cyclosporine thiab cephalosporin yog ob lub ntsiab lus uas tau muab rho tawm los ntawm cov tshuaj fungi.
- Ob lub tebchaw tau txheeb pom nyob rau xyoo 20th Century thiab siv los kho ntau yam kab mob tib neeg
- Cov tshuaj no tuaj yeem noj ntawm qhov ncauj.
- Ob leeg muaj kev phiv.
Qhov txawv ntawm Cyclosporine thiab Cephalosporin yog dab tsi?
Cyclosporine yog tshuaj tiv thaiv kab mob keeb kwm los ntawm cov kab mob Tolypocldium infatum, thaum cephalosporin yog tshuaj tua kab mob β-lactam Ameslikas tau los ntawm cov kab mob Acremonium. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cyclosporine thiab cephalosporin.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm cyclosporine thiab cephalosporin hauv daim ntawv qhia rau kev sib piv ntawm ib sab.
Summary – Cyclosporine vs Cephalosporin
Cyclosporine thiab cephalosporin yog ob lub tebchaw uas tau muab rho tawm los ntawm fungi. Cyclosporine yog ib qho tshuaj tiv thaiv kab mob uas tau tsim los ntawm cov kab mob Tolypocldium infatum, thaum cephalosporin yog tshuaj tua kab mob β-lactam Ameslikas muab los ntawm fungus Acremonium. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm cyclosporine thiab cephalosporin.
