Qhov sib txawv tseem ceeb ntawm alt="" "Image" thiab AST yog qhov"Image" (alanine transaminase) yog ib qho enzyme uas catalyzes hloov ntawm ib pawg amino los ntawm L-alanine mus rau α -ketoglutarate thaum AST (aspartate transaminase) yog ib qho enzyme uas catalyzes hloov ntawm ib pawg amino los ntawm L-aspartate rau α-ketoglutarate. alt="
Daim siab enzymes yog cov proteins uas nquag ua kom muaj tshuaj lom neeg hauv lub cev. Cov tshuaj tiv thaiv no suav nrog kev tsim cov kua tsib, tsim cov tshuaj uas pab ua kom lub plab zom mov, rhuav tshem cov zaub mov thiab co toxins, thiab tawm tsam cov kab mob. Qee lub siab enzymes suav nrog ALP (alkaline phosphatase), "Image" (alanine transaminase), AST (aspartate transaminase), thiab GGT (gamma-glutamyl transferase). Yog tias lub siab raug mob, cov enzymes no tau tso rau hauv cov hlab ntsha. alt="
"Image" (Alanine Transaminase) yog dab tsi? alt="</h2" />
ALT yog ib qho enzyme uas catalyzes hloov ntawm ib pawg amino los ntawm L-alanine mus rau α-ketoglutarate. Cov khoom ntawm no reversible transamination cov tshuaj tiv thaiv yog pyruvate thiab glutamate. alt=""Image" yog ib qho enzyme uas muaj nyob hauv daim siab. Nws yog yav tas los hu ua serum glutamate-pyruvate transaminase lossis serum glutamic-pyruvic transaminase (SGPT). alt=" " "Image" yog thawj tus yam ntxwv ntawm Arthur Karmen thiab cov npoj yaig hauv xyoo 1950. alt=""Image" xav tau cov coenzyme pyridoxal phosphate rau nws cov yeeb yam. Hauv alt=" " "Image" catalyzed cov tshuaj tiv thaiv, pyridoxal phosphate hloov mus rau hauv pyridoxamine hauv thawj theem ntawm cov tshuaj tiv thaiv, thaum cov amino acid hloov mus rau hauv ketoacid."Duab" feem ntau pom hauv daim siab. Nws tseem muaj nyob hauv ntau lub cev nqaij daim tawv thiab ntshav. alt="
Daim duab 01: ALT
Ntxiv mus, ib nrab-lub neej ntawm alt="" "Duab" hauv kev ncig yog nyob ib puag ncig 47 teev. alt=" "Duab" yog tshem tawm los ntawm cov hlwb sinusoidal hauv daim siab. Tsis tas li ntawd, kev nce qib ntawm "Duab" feem ntau qhia tias muaj kev kho mob xws li kab mob siab kab mob siab, ntshav qab zib, mob plawv tsis ua hauj lwm, daim siab puas, teeb meem kab mob, kab mob mononucleosis, lossis myopathy. alt="
AST (Aspartate Transaminase) yog dab tsi?
AST yog ib qho enzyme uas catalyzes hloov ntawm ib pawg amino los ntawm L-aspartate rau α-ketoglutarate. AST kuj catalyzes kev sib hloov ntawm aspartate thiab α-ketoglutarate rau oxaloacetate thiab glutamate. Nws yog ib qho enzyme uas muaj nyob rau hauv daim siab, hlwb, pancreas, lub plawv, ob lub raum, ntsws, thiab cov leeg pob txha. Raws li ib tug prototypical transaminase, lub enzyme AST tso siab rau PLP (pyridoxal phosphate) hloov cov amino pawg los ntawm aspartate mus rau coj keto acid. Muaj ob lub isoenzymes pom rau qhov tshwj xeeb AST enzyme. Lub cytosolic enzyme (GOT1 / cAST) muab tau los ntawm cov qe ntshav liab thiab lub plawv. Lub mitochondrial isoenzyme (GOT2 / mAST) muaj nyob hauv daim siab.
Daim duab 02: AST
Ntxiv mus, qhov enzyme no tau piav qhia thawj zaug los ntawm Arthur Karmen thiab cov npoj yaig hauv xyoo 1954. Lub neej ib nrab ntawm tag nrho AST hauv kev ncig yog nyob ib ncig ntawm 17 teev (qhov nruab nrab 87 teev rau mitochondrial AST). Cov enzyme no tseem raug tshem tawm los ntawm cov hlwb sinusoidal hauv daim siab. Tsis tas li ntawd, nce qib ntawm AST tuaj yeem qhia txog cov kab mob xws li myocardial infarction, mob pancreatitis, mob hemolytic anemia, kub hnyiab, mob raum mob, kab mob musculoskeletal, thiab raug mob.
Dab tsi yog qhov zoo sib xws ntawm "Image" thiab AST? alt="</h2" />
- ALT thiab AST yog ob lub siab enzymes.
- Ob leeg yog transaminase enzymes.
- Ob qho tib si catalyze hloov ntawm ib pawg amino los ntawm amino acid mus rau keto acid sib xws.
- Lawv xav tau PLP (pyridoxal phosphate) rau lawv cov tshuaj tiv thaiv.
- Ob leeg tau piav qhia thawj zaug los ntawm Arthur Karmen.
- ALT / AST feem ntau yog ntsuas hauv kev kho mob raws li biomarker rau daim siab mob.
- Lawv feem ntau yog tshem tawm los ntawm sinusoidal hlwb hauv daim siab.
Qhov txawv ntawm "Image" thiab AST? alt="</h2" />
ALT (alanine transaminase) yog ib qho enzyme uas catalyzes hloov ntawm ib pawg amino ntawm L-alanine mus rau α-ketoglutarate thaum AST (aspartate transaminase) yog ib qho enzyme uas catalyzes hloov ntawm ib pawg amino los ntawm L-aspartate. rau α-ketoglutarate. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm alt="" "Image" thiab AST. Tsis tas li ntawd,"Image" muaj feem ntau hauv daim siab, nrog rau qhov tsis txaus ntseeg pom muaj nyob hauv ob lub raum, lub plawv, thiab cov leeg pob txha. Ntawm qhov tod tes, AST muaj nyob hauv daim siab, lub plawv, cov leeg pob txha, ob lub raum, lub hlwb, thiab cov qe ntshav liab. alt="
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm "Image" thiab AST nyob rau hauv daim ntawv tabular rau ib sab ntawm kev sib piv. alt="
Summary – ALT vs AST
ALT thiab AST yog ob lub siab transaminase enzymes. alt="" "Image" catalyzes kev hloov ntawm ib pawg amino los ntawm L-alanine mus rau α-ketoglutarate, thaum AST catalyzes hloov cov amino pawg los ntawm L-aspartate mus rau α-ketoglutarate. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm"Image" thiab AST. alt="
