Qhov sib txawv tseem ceeb ntawm thyroglobulin thiab antithyroglobulin yog tias thyroglobulin yog cov protein ua los ntawm cov thyroid caj pas, thaum antithyroglobulin yog cov tshuaj tiv thaiv kab mob lossis cov protein uas tau tsim los teb rau thyroglobulin los ntawm lub cev tiv thaiv kab mob.
Thyroglobulin thiab antithyroglobulin yog ob qho proteins tseem ceeb uas cuam tshuam rau kev ua haujlwm ntawm cov thyroid caj pas. Cov thyroid caj pas yog cov qog endocrine pom nyob rau hauv cov vertebrates. Hauv tib neeg, nws yog nyob rau pem hauv ntej ntawm lub caj dab thiab muaj ob lub lobes txuas. Cov thyroid caj pas kuj nyob hauv qab Adas lub kua. Cov haujlwm ua haujlwm ntawm cov thyroid caj pas yog spherical-shaped thyroid follicle. Cov thyroid follicle yog lined nrog follicular hlwb (thyrocytes) thiab qee zaus parafollicular hlwb. Ntxiv mus, thyroid caj pas secretes peb cov tshuaj hormones, suav nrog triiodothyronine (T3), thyroxine, (T4), thiab calcitonin. Cov thyroid hormones cuam tshuam cov protein synthesis thiab kev loj hlob thiab kev loj hlob ntawm cov menyuam yaus, thaum calcitonin plays lub luag haujlwm hauv calcium homeostasis.
YThyroglobulin yog dab tsi?
Y Thyroglobulin yog cov protein ua los ntawm cov thyroid caj pas. Cov protein no muaj qhov hnyav molecular ntawm 660 kDa. Nws kuj yog ib qho dimeric glycoprotein tsim los ntawm follicular hlwb ntawm cov thyroid. Thyroglobulin yog siv tag nrho hauv cov thyroid caj pas. Tib neeg thyroglobulin yog homodimer ntawm subunits, nrog rau txhua tus muaj 2768 amino acids.
Daim duab 01: Thyroglobulin
Thyroglobulin protein yog nyob rau hauv tag nrho cov vertebrates, thiab nws yog lub ntsiab precursor rau cov thyroid hormones. Cov thyroid hormones yog tsim thaum thyroglobulin's tyrosine residues ua ke nrog iodine, thiab cov protein yog tom qab cleaved. Txhua thyroglobulin protein molecule muaj li ntawm 100 txog 200 tyrosine residues. Tab sis tsuas yog ib tug me me ntawm cov tyrosine residues raug iodination los ntawm thyroperoxidase nyob rau hauv follicular colloid. Tsis tas li ntawd, cov metabolism hauv thyroglobulin tshwm sim hauv daim siab ntawm cov thyroid caj pas rov ua dua ntawm thyroglobulin. Lub thyroglobulin circulating muaj ib nrab-lub neej ntawm 65 teev. Tsis tas li ntawd, thyroglobulin tau pom tias muaj kev cuam tshuam nrog kev khi immunoglobulin proteins.
YAntithyroglobulin yog dab tsi?
Antithyroglobulin yog ib qho tshuaj tiv thaiv kab mob lossis cov protein uas tau ua los teb rau thyroglobulin los ntawm lub cev tiv thaiv kab mob. Feem ntau, antithyroglobulin tsis pom hauv lub cev. Txawm li cas los xij, antithyroglobulin tuaj yeem tshwm sim hauv 1 ntawm 10 tus neeg ib txwm muaj me me. Feem ntau ntawm cov tshuaj antithyroglobulin tuaj yeem pom hauv cov neeg mob uas muaj cov thyroid carcinoma. Lub xub ntiag ntawm cov tshuaj tiv thaiv no tuaj yeem ua rau qis qis (lossis tsis tshua muaj qhov tsis tseeb siab) qib ntawm thyroglobulin qhia.
Tib neeg yuav xav tau qhov kev sim hu ua thyroglobulin antibody test yog tias tus kws kho mob xav tias lawv muaj cov thyroid teeb meem. Thyroglobulin antibodies tuaj yeem pom nyob rau hauv cov neeg uas muaj cov thyroid teeb meem xws li cov thyroid tsis ua haujlwm (hypothyroidism) lossis cov thyroid ntau dhau (hyperthyroidism). Thyroglobulin antibodies tua thyroglobulin proteins thiab tuaj yeem rhuav tshem cov thyroid caj pas. Ntxiv mus, antithyroglobulin pom nyob rau hauv cov neeg mob Hashimoto's thyroiditis los yog Graves's disease. Tsis tas li ntawd, cov tshuaj antithyroglobulin kuj pom nyob rau hauv cov neeg mob uas muaj Hashimoto's encephalopathy, uas yog cov kab mob neuroendocrine cuam tshuam nrog tab sis tsis tshwm sim los ntawm Hashimoto's thyroiditis.
Dab tsi zoo sib xws ntawm Thyroglobulin thiab Antithyroglobulin?
- Thyroglobulin thiab antithyroglobulin yog ob qho proteins tseem ceeb uas cuam tshuam rau kev ua haujlwm ntawm cov thyroid caj pas.
- ob leeg yog tsim los ntawm cov amino acids.
- Lawv tuaj yeem sib tham sib.
- Lawv tuaj yeem ntsuas tau los ntawm kev ntsuas tshwj xeeb hauv chav kuaj.
Qhov txawv ntawm Thyroglobulin thiab Antithyroglobulin yog dab tsi?
Thyroglobulin yog cov protein ua los ntawm cov thyroid caj pas, thaum antithyroglobulin yog cov tshuaj tiv thaiv kab mob lossis cov protein uas tau tsim los teb rau thyroglobulin los ntawm lub cev. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm thyroglobulin thiab antithyroglobulin. Tsis tas li ntawd, thyroglobulin yog ntsuas los ntawm kev ntsuas thyroglobulin, thaum antithyroglobulin ntsuas los ntawm kev ntsuas antithyroglobulin.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm thyroglobulin thiab antithyroglobulin hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Thyroglobulin vs Antithyroglobulin
Thyroid yog npauj npaim-zoo li cov qog endocrine uas zaum qis rau pem hauv ntej ntawm caj dab. Thyroglobulin thiab antithyroglobulin yog ob qho tseem ceeb cov proteins uas tuaj yeem cuam tshuam kev ua haujlwm ntawm cov thyroid caj pas. Thyroglobulin yog ib qho protein ua los ntawm cov thyroid caj pas, thaum antithyroglobulin yog ib qho tshuaj tiv thaiv kab mob uas tau ua los ntawm cov tshuaj tiv thaiv kab mob thyroglobulin. Yog li, qhov no qhia txog qhov sib txawv ntawm thyroglobulin thiab antithyroglobulin.
