Qhov sib txawv tseem ceeb ntawm clastogen thiab aneugen yog tias clastogen induces so hauv chromosomes, ua rau seem ntawm chromosomes ntxiv, tshem tawm, los yog rov kho dua, thaum aneugen cuam tshuam rau kev faib cell thiab mitotic spindle apparatus, ua rau poob lossis nce tag nrho. chromosomes.
Genotoxicity feem ntau tau piav qhia tias yog cov cuab yeej ntawm cov tshuaj tua kab mob ua rau muaj kev puas tsuaj ntawm cov ntaub ntawv caj ces hauv ib lub xovtooj ntawm tes. Qhov no ua rau kev hloov pauv thiab tuaj yeem ua rau mob qog noj ntshav. Cov kev hloov pauv no muaj qhov cuam tshuam ncaj qha lossis tsis ncaj qha rau DNA. Tag nrho cov mutagens yog genotoxic, whereas tsis yog tag nrho cov genotoxic tshuaj yog mutagenic. Clastogen thiab aneugen yog ob yam mutagenic, genotoxic tshuaj.
Clastogen yog dab tsi?
A clastogen yog mutagenic, genotoxic tus neeg sawv cev uas cuam tshuam cov txheej txheem DNA cuam tshuam hauv lub cell. Nws ncaj qha ua rau DNA strand breakages, ua rau deletion, insertion, los yog rearrangement ntawm tag nrho cov chromosome seem. Cov DNA strand breakages yog ib hom mutagenesis, uas tuaj yeem ua rau mob qog noj ntshav yog tias tsis kho. Muaj ntau lub npe clastogens, suav nrog acridine daj, benzene, ethylene oxide, arsenic, phosphine, mimosine, actinomycin D, camptothecin, methotrexate, methyl acrylate, resorcinol, thiab 5-fluorodeoxyuridine. Ntxiv rau qhov ntawd, 1, 2-dimethylhydrazine tseem hu ua colon carcinogen thiab qhia pom tias muaj cov haujlwm clastogenic. Qee cov clastogens tsuas pom muaj cov haujlwm clastogenic hauv qee hom hlwb. Piv txwv li, caffeine nthuav tawm cov haujlwm clastogenic hauv cov nroj tsuag nkaus xwb. Clastogens tuaj yeem cuam tshuam rau niam txiv cov kab mob, uas tuaj yeem ua rau muaj kev cuam tshuam hauv kev loj hlob ntawm fetus.
Daim duab 01: Qhov cuam tshuam ntawm kev raug rau Anegens thiab Clastogens ntawm DNA
Muaj ntau ntau txoj hauv kev rau kev sim rau kev ua haujlwm ntawm clastogens. Ob txoj hauv kev tshaj plaws yog kev tshem tawm (DEL) kev soj ntsuam thiab kuaj micronucleus. Txawm li cas los xij, cov kev sim no siv sijhawm ntev heev. Yog li, cov txheej txheem tshiab rau kev soj ntsuam clastogens yog qhov xav tau heev. Ib qho txheej txheem zoo li no yog kev siv cov kab mob monochromosomal hybrid rau kev kuaj pom cov chromosomes tsis raug.
Aneugen yog dab tsi?
Aneugen yog ib yam tshuaj genotoxic uas ua rau tus ntxhais cell muaj tus lej ntawm chromosomes txawv txav. Qhov xwm txheej no hu ua aneuploidy. Aneugen yog mutagenic, genotoxic tus neeg sawv cev uas cuam tshuam rau lub cell division thiab mitotic spindle apparatus, ua rau poob los yog nce ntawm tag nrho cov chromosomes. Kev cuam tshuam ntawm cov txiv neej rau kev ua neej sib txawv, ib puag ncig lossis kev ua haujlwm raug mob tuaj yeem ua rau muaj kev pheej hmoo ntawm spermatozoa aneuploidy. Cov pa luam yeeb muaj cov tshuaj uas ua rau DNA puas. Yog li ntawd, kev haus luam yeeb kuj tuaj yeem ua rau mob aneuploidy. Nws tau raug txheeb xyuas tias kev haus luam yeeb nce chromosome 13 disomy hauv spermatozoa peb zaug thiab YY disomy los ntawm ob npaug.
Daim duab 02: Fenvalerate
Ntxiv mus, cov tshuaj tua kab xws li fenvalerate thiab carbonyl tau raug txheeb xyuas los ua kom cov spermatozoa aneuploidy. Tsis tas li ntawd, tib neeg feem ntau raug rau cov tshuaj perfluorinated (PFCs). Cov neeg uas tau kis tus kab mob no nyob rau hauv cov ntshav los yog cov hlab ntsha hauv cov ntshav muaj cov phev spermatozoa nrog ntau ntau DNA fragmentation thiab chromosomal aneuploidies.
Dab tsi yog qhov zoo sib xws ntawm Clastogen thiab Aneugen?
- Clastogen thiab aneugen yog ob yam mutagenic, genotoxic tshuaj.
- Ob yam khoom ua rau muaj kev hloov pauv hauv chromosomes.
- Lawv kuj ua rau mob qog noj ntshav.
- Lub genotoxicity ntawm ob yam tshuaj tuaj yeem ntsuas los ntawm kev kuaj hauv vitro micronucleus.
Qhov txawv ntawm Clastogen thiab Aneugen yog dab tsi?
Clastogen yog ib qho mutagenic, genotoxic tus neeg sawv cev uas ua rau tawg hauv chromosomes, ua rau ntu ntawm chromosomes ntxiv, tshem tawm, lossis rov kho dua, thaum aneugen yog mutagenic, genotoxic tus neeg sawv cev uas cuam tshuam rau kev faib cell thiab mitotic spindle apparatus, ua rau poob los yog nce ntawm tag nrho cov chromosomes. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm clastogen thiab aneugen. Tsis tas li ntawd, clastogen tsis ua rau aneuploidy, tab sis aneugen ua rau aneuploidy.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm clastogen thiab aneugen hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Clastogen vs Aneugen
Clastogen thiab aneugen yog ob yam khoom uas ua rau genotoxicity. Clastogen yog ib tug mutagenic, genotoxic tus neeg sawv cev uas induces so nyob rau hauv chromosomes, ua rau seem ntawm chromosomes yuav tsum tau ntxiv, tshem tawm, los yog rearranged. Aneugen yog mutagenic, genotoxic tus neeg sawv cev uas cuam tshuam rau lub cell division thiab mitotic spindle apparatus, ua rau poob los yog nce ntawm tag nrho cov chromosomes. Yog li, qhov no qhia txog qhov sib txawv ntawm clastogen thiab aneugen.
