Qhov sib txawv tseem ceeb ntawm MEN1 thiab MEN2 yog tias MEN 1 (ntau yam endocrine neoplasia 1) yog ib qho kab mob caj ces uas ua rau cov qog nqaij hlav hauv lub caj pas pituitary, caj pas parathyroid, thiab txiav txiav, thaum MEN 2 (ntau yam endocrine neoplasia 2.) yog ib qho kab mob caj ces uas ua rau cov qog nqaij hlav hauv cov thyroid caj pas, lub caj pas parathyroid, lossis qog adrenal.
Cov kab mob endocrine yog tsim los ntawm cov qog thiab cov hlwb uas tsim cov tshuaj hormones thiab tso rau hauv cov ntshav. Ntau yam endocrine neoplasia (MEN) yog ib qho kev cuam tshuam ntawm caj ces uas cuam tshuam rau cov kab mob endocrine. Muaj ntau ntau hom kab mob endocrine neoplasia uas ua rau ntau hom qog.
MEN1 yog dab tsi (Multiple Endocrine Neoplasia 1)?
Ntau yam endocrine neoplasia 1 (MEN 1) yog ib qho kab mob caj ces uas ua rau cov qog nqaij hlav hauv pituitary caj pas, caj pas parathyroid, thiab pancreas. Nws yog qee zaum hu ua Wermer's syndrome, raws li nws tau piav qhia thawj zaug los ntawm Paul Wermer xyoo 1954. MEN1 feem ntau tshwm sim los ntawm kev hloov pauv hauv MEN1 noob. Cov noob no muab cov lus qhia rau kev tsim cov protein hu ua menin. Menin protein ua lub luag haujlwm tseem ceeb hauv kev ua kom cov hlwb tsis txhob loj hlob thiab sib faib nrawm dhau. Qhov teeb meem no qhia tau hais tias autosomal dominant qub txeeg qub teg.
Daim duab 01: MEN1 thiab MEN2
Feem ntau, cov qog nqaij hlav hauv cov qog saum toj no yog qhov zoo. Txawm li cas los xij, cov qog loj hlob hauv lub caj pas pituitary, caj pas parathyroid, thiab pancreas tuaj yeem tsim thiab tso cov tshuaj hormones ntau dhau uas ua rau muaj tus kabmob. Cov tshuaj hormones ntau dhau tuaj yeem ua rau muaj ntau yam cim thiab cov tsos mob. Cov tsos mob thiab cov tsos mob no muaj xws li nkees, pob txha, mob, pob txha tawg, pob zeb raum, thiab rwj hauv plab. Kev kuaj mob ntawm tus kab mob no feem ntau yog ua los ntawm kev kuaj ntshav, kuaj ntshav (MRI, CT scan, PET scan, nuclear tshuaj scan, endoscopic ultrasound), thiab kuaj caj ces. Cov kev kho mob rau MENI qog nyob rau hauv lub caj pas pituitary, lub caj pas parathyroid, thiab pancreas muaj xws li kev phais me me, tshuaj kho mob, thiab hluav taws xob.
Tus txiv neej yog dab tsi (Ntau yam Endocrine Neoplasia 2)?
Ntau yam endocrine neoplasia 2 (MEN 2) yog ib yam kab mob caj ces uas ua rau cov qog nqaij hlav hauv cov thyroid caj pas, cov qog nqaij hlav parathyroid, lossis qog adrenal. Qhov mob no yog vim muaj kev hloov pauv hauv cov noob hu ua RET. RET yog ib qho proto-oncogene nyob rau ntawm chromosome 10. Thaum hloov pauv, nws dhau los ua ib qho oncogene thiab ua rau cov cell loj hlob tsis tau thiab tsim cov qog. MEN2 tuaj yeem yog vim muaj kev hloov pauv qub thiab kev hloov pauv tsis sib xws. Nws muab faib ua peb hom: MEN2A, tsev neeg modularly thyroid cancer, MEN2B.
Cov tsos mob thiab cov tsos mob ntawm tus kab mob no muaj xws li ib pob nyob rau hauv pem hauv ntej ntawm lub caj dab, nyuaj hais lus, nyuaj rau nqos, ua tsis taus pa, lymph nodes loj, caj pas thiab caj dab mob, kev nyuaj siab, ntxhov siab vim, mob taub hau, tsis meej pem, xeev siab, tsis qab los noj mov, mob plab, cem quav, mob pob txha thiab pob qij txha, osteoporosis, ntshav siab, poob phaus, tshee, alacrima, mucosal neuromas, daim tawv muag eversion, thiab scoliosis. Kev kuaj mob feem ntau yog los ntawm tsev neeg keeb kwm, kuaj ntshav kuaj lub cev, X-rays, thiab kuaj caj ces. Cov kev kho mob muaj xws li tshem tawm cov qog los ntawm kev phais (prophylactic thyroidectomy, tshem tawm cov qog parathyroid, tshem tawm cov qog adrenal), laparoscopic laparotomy, calcimimetics (tswj qib ntawm parathyroid hormone), alpha-adrenergic blockers, thiab beta-adrenergic blockers rau kub siab.
Dab tsi yog qhov zoo sib xws ntawm MEN1 thiab MEN2?
- MEN1 thiab MEN2 yog ob hom kab mob endocrine neoplasias.
- Ob hom ua rau cov qog nqaij hlav hauv cov qog endocrine.
- Ob hom tuaj yeem tshwm sim raws li cov xwm txheej qub txeeg qub teg los yog tsis sib xws.
- Yog tau txais qub txeeg qub teg, ob hom qhia autosomal dominant qub txeeg qub teg.
- Nyob rau hauv ob qho tib si, cov qog tej zaum yuav yog benign los yog mob cancer.
- Cov xwm txheej no kho tau los ntawm kev phais.
Qhov txawv ntawm MEN1 thiab MEN2 yog dab tsi?
MEN 1 yog ib yam kab mob caj ces uas ua rau cov qog nqaij hlav hauv lub caj pas pituitary, caj pas parathyroid, thiab pancreas, thaum txiv neej 2 yog ib yam kab mob caj ces uas ua rau cov qog nqaij hlav hauv cov thyroid caj pas, lub caj pas parathyroid, lossis qog adrenal. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm MEN1 thiab MEN2. Tsis tas li ntawd, MEN1 yog tshwm sim los ntawm kev hloov pauv hauv MEN1 noob, thaum MEN2 yog tshwm sim los ntawm kev hloov pauv hauv RET gene.
Cov hauv qab no qhia txog qhov sib txawv ntawm MEN1 thiab MEN2 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – MEN1 vs MEN2
Ntau yam kab mob endocrine neoplasia yog ib qho mob caj ces uas muaj ntau yam mob sib txawv uas muaj cov qog ntawm cov qog endocrine. Qee cov qog yog benign, thiab lwm tus yog malignant. MEN1 thiab MEN2 yog ob hom ntawm ntau yam endocrine neoplasia. Txiv neej 1 yog ib yam kab mob caj ces uas ua rau cov qog nqaij hlav hauv lub caj pas pituitary, caj pas parathyroid, thiab pancreas thaum tus txiv neej 2 yog ib yam kab mob caj ces uas ua rau cov qog nqaij hlav hauv cov thyroid caj pas, caj pas parathyroid, lossis qog adrenal. Yog li, qhov no yog qhov txawv ntawm MEN1 thiab MEN2.
