Qhov sib txawv tseem ceeb ntawm prolactin thiab macroprolactin yog tias prolactin yog cov protein ntau hauv lub cev uas paub zoo tshaj plaws rau nws lub luag haujlwm hauv kev ua kom cov poj niam tsim cov mis nyuj, thaum macroprolactin yog cov protein uas tsis muaj zog ntawm lub cev isoform ntawm prolactin pom nyob rau hauv ib feem me me ntawm neeg.
Prolactin tseem hu ua lactotropin. Nws yog ib qho active protein uas ua rau cov poj niam tsim cov mis nyuj. Nws yog secreted los ntawm pituitary teb rau noj, mating, estrogen kho, ovulation, los yog laus. Ntawm qhov tod tes, macroprolactin yog cov protein uas tsis yog bioactive isoform ntawm prolactin. Yog li ntawd, prolactin thiab macroprolactin yog ob qho tib si nquag thiab tsis muaj zog protein molecules pom hauv tib neeg.
YProlactin yog dab tsi?
Prolactin yog cov tshuaj hormones protein uas tso tawm los ntawm cov qog pituitary anterior. Cov tshuaj no txhawb nqa lactation nyob rau hauv teb rau lub suckling stimulus ntawm cov me nyuam mos tshaib plab. Nws tuaj yeem cuam tshuam ntau dua 300 cov txheej txheem sib cais hauv ntau yam vertebrates, suav nrog tib neeg. Nws tseem yog secreted hnyav heev hauv pulses nyob nruab nrab ntawm cov txheej xwm xws li noj, mating, estrogen kho, ovulation los yog laus. Prolactin plays lub luag haujlwm tseem ceeb hauv cov metabolism, tswj kev tiv thaiv kab mob, thiab kev loj hlob ntawm pancreatic. Cov protein no tau pom thawj zaug hauv xyoo 1930 los ntawm Oscar Riddle los ntawm cov tsiaj tsis yog tib neeg. Nws lub xub ntiag tau lees paub hauv tib neeg hauv xyoo 1970 los ntawm Henry Friesen. Ntxiv mus, prolactin yog peptide hormone encoded los ntawm PRL noob.
Daim duab 01: Prolactin
Nyob hauv cov tsiaj nyeg, prolactin pom tias muaj feem cuam tshuam nrog kev tsim mis nyuj. Txawm li cas los xij, hauv cov ntses, nws koom nrog kev tswj dej thiab ntsev sib npaug. Cov tshuaj hormones protein no kuj ua raws li cytokine thiab yog ib qho tseem ceeb ntawm kev tiv thaiv kab mob. Nws muaj lub luag haujlwm tseem ceeb hauv lub voj voog ntawm tes raws li qhov tseem ceeb ntawm kev loj hlob, sib txawv, thiab tiv thaiv apoptotic yam. Tsis tas li ntawd, raws li kev loj hlob zoo, prolactin khi rau cytokine-zoo li receptors thiab cuam tshuam hematopoiesis, angiogenesis, thiab kev tswj cov ntshav txhaws. Ntau qhov sib txawv thiab isoforms ntawm cov protein no paub tias muaj nyob hauv cov ntses thiab tib neeg.
Macroprolactin yog dab tsi?
Macroprolactin yog ib qho physiologically inactive protein isoform ntawm prolactin pom nyob rau hauv ib tug me me feem ntawm cov neeg. Qhov no isoform ntawm prolactin tsis yog bioactive. Nws feem ntau yog tsim los ntawm prolactin monomer thiab ib qho IgG molecule. Nws muaj lub sijhawm ntev tshem tawm zoo ib yam li cov tshuaj immunoglobulins. Ntxiv mus, qhov isoform no yog qhov chaw kho mob uas tsis muaj tshuaj tiv thaiv, tab sis nws cuam tshuam nrog cov tshuaj tiv thaiv kab mob siv rau kev kuaj pom ntawm prolactin. Yog li, macroprolactin tseem ceeb heev vim qee qhov kev soj ntsuam kuaj yuav kuaj pom macroprolactin li prolactin. Qhov no ua rau muaj qhov ua tsis ncaj ncees ntawm prolactin tshwm sim hauv kev sim kuaj. Tsis tas li ntawd, qhov no tuaj yeem ua rau muaj qhov tsis zoo ntawm hyperprolactinemia hauv qee tus neeg, tshwj xeeb tshaj yog cov neeg muaj cov tsos mob xws li kev xeeb tub thiab muaj teeb meem kev coj khaub ncaws. Muaj qee yam tshuaj, xws li polyethylene glycol, uas tshem tawm macroprolactin ntawm lub cev.
Dab tsi zoo sib xws ntawm Prolactin thiab Macroprolactin?
- Prolactin thiab macroprolactin yog ob lub zog thiab tsis ua haujlwm protein molecules pom hauv tib neeg.
- Lawv yog cov proteins uas tsim los ntawm cov amino acids.
- Ob daim ntawv no muaj nyob rau hauv poj niam thiab txiv neej.
- Cov ntaub ntawv no muaj nyob rau hauv cov neeg laus cov ntshav.
- Ob daim ntawv tuaj yeem kuaj pom los ntawm kev kuaj sim.
Qhov txawv ntawm Prolactin thiab Macroprolactin yog dab tsi?
Prolactin yog cov protein uas muaj lub cev muaj zog uas paub zoo tshaj plaws rau nws lub luag haujlwm hauv kev ua kom cov poj niam tsim cov mis nyuj, thaum macroprolactin yog cov protein uas tsis muaj zog ntawm lub cev isoform ntawm prolactin pom nyob rau hauv ib feem me me ntawm tib neeg. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm prolactin thiab macroprolactin. Tsis tas li ntawd, qhov hnyav molecular ntawm prolactin yog 23 kDa thaum lub cev hnyav ntawm prolactin yog 150 kDa.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm prolactin thiab macroprolactin hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Prolactin vs Macroprolactin
Prolactin thiab macroprolactin yog ob lub zog thiab tsis ua haujlwm ntawm cov protein molecules pom hauv tib neeg. Prolactin yog ib qho physiologically active protein uas paub zoo tshaj plaws rau nws lub luag hauj lwm nyob rau hauv pab cov poj niam los tsim cov mis nyuj, thaum macroprolactin yog ib tug physiologically inactive protein isoform ntawm prolactin pom nyob rau hauv tib neeg. Yog li, qhov no qhia txog qhov sib txawv ntawm prolactin thiab macroprolactin.
