Qhov sib txawv tseem ceeb ntawm IDH1 thiab IDH2 yog tias isocitrate dehydrogenase 1 (IDH1) yog cytosol enzyme coded los ntawm IDH1 noob hauv tib neeg, thaum isocitrate dehydrogenase 2 (IDH2) yog mitochondrial enzyme coded los ntawm IDH2 noob hauv tib neeg..
Kev ntxhov siab Oxidative tshwm sim thaum lub cev lom neeg zoo li lub xovtooj ntawm tes tsis tuaj yeem detoxify reactive intermediates (reactive oxygen hom) los yog kho puas los ntawm reactive intermediates. Kev cuam tshuam rau lub xeev redox ntawm lub cell tuaj yeem ua rau muaj kev phom sij los ntawm kev tsim cov peroxides thiab dawb radicals. Peroxides thiab dawb radicals yuav ua rau tag nrho cov khoom ntawm lub cell, nrog rau cov proteins, lipids, thiab DNA. IDH1 thiab IDH2 yog ob lub enzymatic proteins koom nrog hauv mitigating oxidative puas tsuaj rau cov kab mob lom.
IDH1 yog dab tsi?
IDH1 yog cytosol enzyme encoded los ntawm IDH1 noob hauv tib neeg. IDH1 noob muaj nyob rau hauv chromosome 2. Nyob rau hauv ib lub cell, lub IDH1 enzyme functions nyob rau hauv lub cytoplasm, peroxisome, thiab endoplasmic reticulum. Qhov no enzyme catalyzes oxidative decarboxylation ntawm isocitrate rau α-ketoglutarate. Cov tshuaj tiv thaiv no tso cai rau txo qis ntawm NADP + rau NADPH. Txij li thaum α-ketoglutarate thiab NADPH muaj nuj nqi hauv cellular detoxification txheej txheem vim oxidative kev nyuaj siab, IDH1 kuj indirectly koom nyob rau hauv mitigating oxidative puas. Ntxiv nrog rau cov haujlwm saum toj no, IDH1 kuj tseem ua rau β-oxidation ntawm unsaturated fatty acids hauv peroxisomes ntawm daim siab hlwb. Tsis tas li ntawd, nws koom nrog kev tswj hwm ntawm cov piam thaj hauv cov insulin secretion. Tsis tas li ntawd, IDH1 ua tus thawj tsim ntawm NADPH hauv feem ntau cov ntaub so ntswg, suav nrog lub hlwb.
Daim duab 01: IDH1
IDH1 noob kev hloov pauv ua rau muaj qhov txawv txav ntawm 2-hydroxyglutarate uas inhibits alpha-ketoglutarate-dependent enzymes xws li histone thiab DNA demethylases. Qhov no tuaj yeem ua rau muaj kev hloov pauv mus rau histone thiab DNA methylation, uas ua rau qog nqaij hlav. Kev hloov pauv hauv cov noob IDH1 ua rau metaphyseal chondromatosis nrog aciduria. Qhov kev hloov pauv noob no kuj tau pom nyob rau hauv diffuse astrocytoma, anaplastic astrocytoma, oligodendroglioma, anaplastic oligodendroglioma, oligoastrocytoma, anaplastic oligoastrocytoma, thiab theem nrab glioblastoma. Sib nrug los ntawm cov saum toj no, IDH1 kev hloov pauv kuj pom nyob rau hauv tib neeg mob myeloid leukemia. Qee cov tshuaj, xws li Ivosidenib uas ua rau mob myeloid leukemia nrog kev hloov pauv IDH1, tau pom zoo los ntawm FDA
IDH2 yog dab tsi?
IDH2 yog mitochondrial enzyme. IDH2 noob encodes cov enzyme no. IDH2 noob muaj nyob rau hauv chromosome 15 hauv tib neeg. Zoo ib yam li IDH1 enzyme, IDH2 enzyme kuj catalyzes oxidative decarboxylation ntawm isocitrate rau α-ketoglutarate. IDH2 feem ntau pom muaj nyob rau hauv mitochondria thiab plays lub luag haujlwm tseem ceeb hauv cov metabolism hauv nruab nrab thiab lub zog metabolism. Cov protein no nruj nreem cuam tshuam nrog pyruvate dehydrogenase complex.
Daim duab 02: IDH2
Somatic kev hloov pauv ntawm IDH2 noob kuj tau pom tias muaj feem cuam tshuam nrog kev kho mob xws li Ollier kab mob thiab Maffucci syndrome. Ntxiv mus, kev hloov pauv hauv IDH2 noob yog lub luag haujlwm rau ntau yam kab mob xws li 2 hydroxyglutaric aciduria, glioma, mob myeloid leukemia, chondrosarcoma, intrahepatic cholangiocarcinoma, thiab angioimmunoblastic T cell lymphoma. Enasidenib yog ib qho tshuaj pom zoo los ntawm FDA uas tsom rau mob myeloid leukemia nrog kev hloov pauv IDH2.
Dab tsi zoo sib xws ntawm IDH1 thiab IDH2?
- IDH1 thiab IDH2 yog ob lub enzymes koom nrog hauv kev txo qis oxidative kev puas tsuaj rau cov kab mob lom.
- Ob leeg yog cov proteins ua los ntawm cov amino acids.
- Cov enzymes no yog NADP + nyob ntawm.
- Ob lub enzymes catalyze oxidative decarboxylation ntawm isocitrate rau α-ketoglutarate.
- Kev hloov ntawm lawv cov noob tuaj yeem ua rau cov qog sib txawv xws li glioma, mob myeloid leukemia, chondrosarcoma, intrahepatic cholangiocarcinoma, thiab angioimmunoblastic T cell lymphoma.
- Kev hloov pauv ntawm cov noob teb tau zoo rau kev kho mob thiab xov tooj cua.
Qhov txawv ntawm IDH1 thiab IDH2 yog dab tsi?
IDH1 yog cytosol enzyme encoded los ntawm IDH1 noob hauv tib neeg, thaum IDH2 yog mitochondrial enzyme encoded los ntawm IDH2 noob hauv tib neeg. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm IDH1 thiab IDH2. Tsis tas li ntawd, IDH1 noob nyob rau hauv chromosome 2, thaum IDH2 noob nyob rau hauv chromosome 15.
Cov hauv qab no infographic nthuav tawm qhov sib txawv ntawm IDH1 thiab IDH2 hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – IDH1 vs IDH2
IDH1 thiab IDH2 yog ob lub enzymes uas ua rau cov oxidative decarboxylation ntawm isocitrate rau α-ketoglutarate. Lawv kuj ua rau txo qis ntawm NADP + rau NADPH. Txij li thaum α-ketoglutarate thiab NADPH muaj nuj nqi hauv cellular detoxification txheej txheem vim oxidative kev nyuaj siab, IDH1 thiab IDH2 kuj indirectly koom rau hauv mitigating oxidative puas. IDH1 yog cytosol enzyme, thaum IDH2 yog mitochondrial enzyme. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm IDH1 thiab IDH2.
