Qhov sib txawv tseem ceeb ntawm G protein ua ke receptors thiab receptor tyrosine kinases yog tias G protein txuas txuas receptors tuaj yeem ua rau tsuas yog ib lub xovtooj teb los ntawm ib qho ligand khi thaum lub receptor tyrosine kinases tuaj yeem ua rau ntau lub xovtooj teb los ntawm ib leeg ligand khi..
Receptors yog cov proteins uas koom nrog hauv cov txheej txheem ntawm tes. Lawv tuaj yeem yog intracellular receptors nrog rau cov cell nto receptors. Cell deg receptors nrhiav qhov chaw ntawm lub hlwb thiab tau txais cov cim qhia thiab dhau mus rau hauv lub cell sab hauv kom hnov qab. Muaj ob lub ntsiab ntawm cell nto receptors; uas yog, lawv yog G protein-coupled receptors thiab receptor tyrosine kinases. Lawv yog cov transmembrane proteins. G protein txuas nrog receptors muaj xya lub transmembrane domains, thiab lawv koom nrog G proteins. Ntawm qhov tod tes, receptor tyrosine kinases yog enzyme-txuas receptors uas koom nrog ATP thiab enzyme kinases.
G Protein Coupled Receptors yog dab tsi?
G protein txuas txuas receptors yog ib hom kab mob sib kis. Raws li lub npe qhia, cov receptors no ua haujlwm nrog G proteins uas koom nrog GTP. GTP yog ib qho molecule zoo li ATP uas muab lub zog rau G cov proteins ua haujlwm. Thaum ib lub ligand khi nrog cov receptor, cov duab ntawm cov receptor hloov nyob rau hauv ib txoj kev uas nws muaj peev xwm cuam tshuam nrog G protein.
Daim duab 01: G Protein Coupled Receptor
Daim ntawv tsis muaj zog ntawm G protein hloov mus rau hauv daim ntawv nquag thiab faib ua ob daim (alpha thiab beta subunits) los ntawm kev hloov GTP rau hauv GDP thiab siv lub zog tso tawm. Cov subunits no ces cais los ntawm G protein ua ke receptor thiab cuam tshuam nrog lwm cov proteins kom ua rau cov lus teb ntawm tes. Raws li kev tsim qauv, G protein txuas txuas receptors muaj xya lub transmembrane domains uas tau hla hla daim nyias nyias.
Receptor Tyrosine Kinases yog dab tsi?
Receptor tyrosine kinases yog ib hom receptor proteins uas koom nrog feem ntau ntawm cov xov tooj ntawm tes taw qhia txoj hauv kev. Raws li lub npe implies, lawv yog kinase enzymes. Kinase yog ib qho enzyme uas catalyzes kev hloov ntawm phosphate pawg mus rau lub substrate. Cov receptors no muaj tyrosine kinases uas hloov ib pawg phosphate los ntawm ATP rau tyrosine. Receptor tyrosine kinase muaj ob lub monomers zoo sib xws.
Daim duab 02: Receptor Tyrosine Kinase
Ib zaug ib qho kev taw qhia molecule khi nrog qhov chaw khi ntawm cov receptor, ob lub monomers tuaj ua ke thiab tsim ib qho dimer. Tom qab ntawd, kinases phosphorylate ATP thiab ntxiv phosphate pawg rau txhua ntawm rau tyrosines. Li no, dimer dhau los ua phosphorylated, uas yog tag nrho activated tyrosine kinase. Activated tyrosine kinase xa cov teeb liab mus rau lwm cov molecules ntawm lub cell thiab mediates teeb liab kis. Cov yam ntxwv tseem ceeb tshaj plaws ntawm receptor tyrosine kinase yog, nws tuaj yeem qhib ntau txoj hauv kev qhia thiab thaum nws qhib, nws tuaj yeem tsim ntau cov lus teb ntawm tes ib zaug.
Dab tsi zoo sib xws ntawm G Protein Coupled Receptors thiab Receptor Tyrosine Kinases?
- Lawv yog cov receptors uas koom nrog cov xovtooj ntawm tes.
- Structurally, lawv yog cov protein molecules.
- Ntxiv mus, lawv yog cov proteins transmembrane.
- Tsis tas li ntawd, lawv yog cov cell nto receptors.
- Thaum pib, lawv nyob twj ywm tsis ua haujlwm thiab tom qab ntawd ua haujlwm thaum khi ib lub ligand rau cov receptor.
Qhov txawv ntawm G Protein Coupled Receptors thiab Receptor Tyrosine Kinases yog dab tsi?
G protein txuas txuas receptors thiab receptor tyrosine kinases yog ob hom cell nto receptors uas kho cov xov tooj ntawm tes taw qhia txoj hauv kev. G protein ua ke receptors koom nrog G proteins thiab GTP. Ntawm qhov tod tes, receptor tyrosine kinases yog enzyme-txuas receptors cuam tshuam nrog tyrosine thiab ATP. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm G protein ua ke receptors thiab receptor tyrosine kinases. Tsis tas li ntawd, ib leeg ligand khi ua rau ntau lub xovtooj ntawm tes teb los ntawm receptor tyrosine kinases thaum tsuas yog ib lub xovtooj teb los ntawm G protein ua ke receptors ntawm ib leeg ligand khi. Yog li, qhov no yog lwm qhov sib txawv ntawm G protein ua ke receptors thiab receptor tyrosine kinases.
Cov ntaub ntawv hauv qab no nthuav tawm cov ntaub ntawv ntxiv txog qhov sib txawv ntawm G protein txuas nrog receptors thiab receptor tyrosine kinases.
Summary – G Protein Coupled Receptors vs Receptor Tyrosine Kinases
G protein txuas txuas receptors thiab receptor tyrosine kinases yog ob hom cell nto receptors. G protein ua ke receptors muaj xya transmembrane domains thaum receptor tyrosine kinases muaj ob lub monomers zoo sib xws. Thaum ib lub ligand khi rau cov receptor, hauv G protein ua ke receptors, G protein tau qhib. Tab sis, hauv receptor tyrosine kinases, tyrosine dimer yog tsim thiab phosphorylated.
Tsis tas li ntawd, G protein ua ke receptors tuaj yeem ua rau tsuas yog ib qho ntawm tes teb thaum lub ligand khi rau cov receptor. Ntawm qhov tod tes, receptor tyrosine kinase tuaj yeem ua rau ntau cov lus teb thaum lub ligand khi rau receptor. Yog li, qhov no qhia txog qhov sib txawv ntawm G protein ua ke receptors thiab receptor tyrosine kinases.
