Qhov sib txawv tseem ceeb ntawm Bcl-2 thiab Bcl-xL yog qhov kev qhia ntawm Bcl-2 tsuas yog tshwm sim hauv tib neeg cov kab mob mesenchymal sib txawv, thaum qhov kev qhia ntawm Bcl-xL tshwm sim hauv ob qho tib si tsis txawv thiab txawv tib neeg mesenchymal qia hlwb..
Apoptosis yog ib txoj hauv kev tshem tawm cov tsis xav tau lossis txawv txav ntawm lub cev ntawm ntau cov kab mob. Nws yog hom programmed cell tuag uas yog ua tib zoo tswj cov txheej txheem. Cov xwm txheej biochemical tshwm sim thaum lub sijhawm apoptosis. Hauv cov qog nqaij hlav cancer, apoptosis raug thaiv. Hauv lwm lo lus, dysregulated apoptosis lossis zam ntawm apoptosis yog qhov laj thawj tseem ceeb rau cov qog nqaij hlav.
Tsis tsim nyog apoptosis tuaj yeem yog vim li cas rau ntau tus tib neeg cov kab mob, suav nrog cov kab mob neurodegenerative, ischemic puas, autoimmune disorders, thiab ntau hom mob qog noj ntshav. B-cell lymphoma-2 (Bcl-2) protein tsev neeg yog ib tsev neeg antiapoptotic protein uas Bcl-2 thiab Bcl-xL yog ob tug tswv cuab. Lawv nyob ntawm endoplasmic reticulum. Lawv tiv thaiv mitochondrial txheej membrane permeabilization thiaj li txhawb nqa cell ciaj sia. Yog li ntawd, lawv koom nrog inhibiting mitochondrial-dependent extrinsic thiab intrinsic cell tuag txoj kev. Thaum tswj hwm apoptosis, lawv txhawb nqa cell ciaj sia.
Bcl-2 yog dab tsi?
Bcl-2 yog prototypic antiapoptotic protein uas yog ib tug tswv cuab ntawm tsev neeg Bcl-2. Nws tseem hu ua B-cell lymphoma 2 protein. Muaj ob isoforms ntawm Bcl-2 protein. Bcl-2 blocks apoptosis thiab txhawb kev ciaj sia ntawm cov hlwb. Cov noob BCL2 cov lej rau Bcl-2 protein, thiab cov noob no nyob ntawm chromosome 18.
Daim duab 01: Bcl-2
Kev hloov ntawm cov noob BCL2 los ntawm chromosome 18 mus rau chromosome 14 yog txuam nrog ntau B-cell leukemias thiab lymphomas. Kev nthuav qhia ntau dhau ntawm Bcl-2 protein lossis kev qhia tsis zoo ntawm Bcl-2 yog lub luag haujlwm ua kom cov qog nqaij hlav cancer tuag. Qhov no yog vim hais tias overexpression ntawm Bcl-2 inhibits apoptotic cell tuag. Txawm li cas los xij, kev poob ntawm Bcl-2 cov proteins muaj qhov cuam tshuam loj rau qee cov ntaub so ntswg homeostasis thiab kev loj hlob. Piv txwv li, kev ciaj sia ntawm lub raum epithelial qia hlwb thaum lub sij hawm embryogenesis, melanocyte progenitors, thiab paub tab B thiab T lymphocytes nyob ntawm Bcl-2. Naive T hlwb vam khom Bcl-2 kom ciaj sia.
Bcl-xL yog dab tsi?
B-cell lymphoma-loj loj lossis Bcl-xL yog cov tswvcuab protein ntawm Bcl-2 antiapoptotic protein tsev neeg. Cov protein no yog coded los ntawm BCL2-zoo li 1 noob. Bcl-xL muaj nyob rau hauv lub mitochondrial daim nyias nyias. Zoo ib yam li Bcl-2 protein, Bcl-xL kuj txhawb nqa cell ciaj sia los ntawm inhibiting apoptosis.
Daim duab 02: Bcl-xL
Bcl-xL inhibits apoptosis los ntawm kev tiv thaiv kev tso tawm ntawm cov ntsiab lus mitochondrial, tshwj xeeb tshaj yog cytochrome c. Nws yog ua los ntawm kev tswj cov mitochondrial membrane permeability. Bcl-xL tshaj tawm tuaj yeem pom hauv cov qog nqaij hlav cancer. Bcl-xL yog lub luag haujlwm antiapoptotic protein hauv hepatocytes. Thaum lub sij hawm hepatocyte regeneration, Bcl-xL qhia pom thaum Bcl-2 tsis pom.
Dab tsi yog qhov zoo sib xws ntawm Bcl-2 thiab Bcl-xL?
- Bcl-2 thiab Bcl-xL yog cov tshuaj tiv thaiv apoptotic.
- Lawv yog cov tswv cuab ntawm tsev neeg anti-apoptotic BcL-2 protein.
- Lawv qhia qhov zoo sib xws hauv plaub BCL-2 homology (BH) thiab cov qauv 3D zoo sib xws.
- Lawv ua lub luag haujlwm tseem ceeb hauv kev tuag ntawm tes.
- Qhov tseeb, lawv ua haujlwm ua ke los tswj apoptosis, cell voj voog ntes, thiab lub voj voog ntawm tes nkag.
- Lawv kuj ua lub luag haujlwm tseem ceeb hauv kev txhim kho mob qog noj ntshav.
- Ob hom proteins tuaj yeem ntes cov hlwb ntawm G0 theem thiab ncua kev nkag mus rau theem S.
- Lawv ncua theem S los ntawm kev ncua G0 lossis G1 theem.
Qhov txawv ntawm Bcl-2 thiab Bcl-xL yog dab tsi?
Bcl-2 yog ib qho antiapoptotic protein coded los ntawm cov noob BCL2 thaum Bcl-xL yog mitochondrial transmembrane protein uas yog ib qho antiapoptotic protein coded los ntawm BCL2-zoo li 1 noob. Ntxiv mus, Bcl-xL yog kwv yees li kaum npaug ntau dua li Bcl-2 thaum raug ntxias los ntawm Doxorubicin. Qhov sib txawv tseem ceeb ntawm Bcl-2 thiab Bcl-xL yog qhov kev qhia Bcl-2 tuaj yeem pom tsuas yog hauv hMSCs sib txawv, thaum Bcl-xL qhia tuaj yeem pom hauv ob qho tib si tsis txawv thiab txawv hMSCs.
Cov ntawv qhia hauv qab no nthuav tawm qhov sib txawv ntawm Bcl-2 thiab Bcl-xL hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Bcl-2 vs Bcl-xL
Kev khiav tawm ntawm apoptosis yog qhov tseem ceeb rau kev loj hlob ntawm cov qog nqaij hlav. Bcl-2 thiab Bcl-xL yog ob qho tshuaj tiv thaiv apoptotic molecules uas muaj kev tiv thaiv kev loj hlob. Lawv ua lub luag haujlwm tseem ceeb hauv inhibiting apoptosis thiab cell proliferation. Qhov sib txawv tseem ceeb ntawm Bcl-2 thiab Bcl-xL yog qhov kev qhia ntawm Bcl-2 tsuas yog tshwm sim hauv tib neeg cov kab mob mesenchymal sib txawv, thaum qhov kev qhia ntawm Bcl-xL tshwm sim hauv ob qho tib si tsis txawv thiab sib txawv tib neeg mesenchymal qia hlwb.
