Qhov qhov sib txawv ntawm neuroblastoma thiab Wilms qog yog tias neuroblastoma yog cov qog nqaij hlav extracranial tshaj plaws hauv menyuam yaus uas feem ntau tshwm sim hauv cov qog adrenal thaum Wilms qog yog cov qog ua rau lub raum loj tshaj plaws hauv menyuam yaus. feem ntau tshwm sim hauv lub raum.
Hom mob qog noj ntshav uas feem ntau tshwm sim hauv cov menyuam yaus txawv ntawm cov neeg laus pom. Muaj tsawg zaus, menyuam yaus tuaj yeem tsim mob qog noj ntshav uas feem ntau pom hauv cov neeg laus. Cov qog nqaij hlav ntawm cov menyuam yaus yog leukemia, qog hlwb thiab txha caj qaum, neuroblastoma, Wilms qog, lymphoma, rhabdomyosarcoma, thiab retinoblastoma. Lwm hom mob qog noj ntshav tsis tshua pom hauv menyuam yaus.
Neuroblastoma yog dab tsi?
Neuroblastoma yog ib hom mob qog noj ntshav uas ib txwm tsim los ntawm cov paj hlwb tsis paub tab pom nyob hauv ntau qhov chaw ntawm lub cev. Nws yog cov qog nqaij hlav extracranial tshaj plaws hauv menyuam yaus thiab feem ntau tshwm sim hauv cov qog adrenal. Txawm li cas los xij, neuroblastoma tuaj yeem tsim nyob rau hauv lwm qhov chaw ntawm lub cev, suav nrog lub plab, hauv siab, caj dab, thiab nyob ze ntawm tus txha nraub qaum uas cov paj hlwb muaj nyob. Neuroblastoma cuam tshuam rau cov menyuam yaus hnub nyoog 5 xyoos lossis qis dua. Tej zaum nws yuav tsis tshua muaj tshwm sim hauv cov menyuam yaus. Cov tsos mob muaj xws li mob plab, ib qho loj hauv qab ntawm daim tawv nqaij uas tsis muaj kev sib tw, kev hloov hauv plab hnyuv, hawb pob, mob hauv siab, hloov ntawm lub qhov muag, proptosis, tsaus voj voog ncig ob lub qhov muag, mob nraub qaum, kub taub hau, poob ceeb thawj, thiab mob pob txha.
Nws tau raug txheeb xyuas tias kev hloov pauv hauv ALK thiab PHOX2B cov noob caj noob ces ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob neuroblastoma hauv tsev neeg. Kwv yees li 1 mus rau 2% ntawm cov menyuam yaus muaj mob neuroblastoma hauv tsev neeg. Daim ntawv no ntawm tus mob tau txais txiaj ntsig muaj tus qauv autosomal dominant qub txeeg qub teg. Cov teeb meem ntawm neuroblastoma tej zaum yuav muaj xws li metastasis, txha caj qaum compression, thiab paraneoplastic syndrome.
Daim duab 01: Neuroblastoma
Cov kev sim uas siv los kuaj tus mob no suav nrog kev kuaj lub cev, kuaj zis thiab ntshav, kuaj ntshav biopsy, X-ray, CT scans, MIBG scans, thiab MRI. Tsis tas li ntawd, txoj kev kho mob muaj xws li kev phais, kws khomob, kev kho hluav taws xob, kev tiv thaiv kab mob, kev hloov cov pob txha pob txha, thiab lwm yam. Cov kws kho mob tam sim no siv txoj kev kho tshiab uas suav nrog cov tshuaj hu ua metaiodobenzylguanidine (MIBG). Cov tshuaj no, thaum txhaj rau hauv cov ntshav, mus rau neuroblastoma thiab tso tawm hluav taws xob los rhuav tshem lawv.
Wilms Tumor yog dab tsi?
Wilms qog yog ib qho mob qog noj ntshav tsawg heev uas feem ntau cuam tshuam rau menyuam yaus. Nws yog qhov mob raum tshaj plaws hauv menyuam yaus uas feem ntau tshwm sim hauv ib lub raum lossis ob lub raum. Nws tseem hu ua nephroblastoma Tus mob qog noj ntshav no feem ntau cuam tshuam rau menyuam yaus thaum muaj hnub nyoog 3 txog 4 xyoos thiab nws yuav tshwm sim tsawg dua tom qab hnub nyoog 5 xyoos. Cov tsos mob yuav muaj xws li mob plab, mob plab, plab o, ua npaws, ntshav hauv cov zis, cem quav, xeev siab, ntuav, cem quav, tsis qab los noj mov, ntshav siab, thiab ua tsis taus pa.
Daim duab 02: Histopathology ntawm Wilms Tumor
Genetically, Wilms qog feem ntau cuam tshuam nrog kev hloov pauv hauv WT1 noob, CTNNB1 noob, lossis AMER1 noob. Kwv yees li ntawm 10% ntawm cov neeg mob ntawm Wilms qog yog cov xwm txheej qub. Yog tias nws tau txais, nws ua raws li tus qauv autosomal dominant qub txeeg qub teg. Tsis tas li ntawd, kev kuaj mob yog ua tiav los ntawm kev kuaj lub cev, kuaj ntshav thiab zis, kuaj duab (ultrasound, CT scan, MRI). Txoj kev kho mob suav nrog kev phais kom tshem tawm ib feem ntawm lub raum, tshem tawm lub raum thiab cov ntaub so ntswg ib puag ncig lossis tshem tawm tag nrho lossis ib feem ntawm ob lub raum. Doxorubicin, cyclophosphamide, etoposide, irinotecan, thiab carboplatin yog cov tshuaj tua kab mob tua Wilms qog. Txoj kev kho hluav taws xob siv cov kab hluav taws xob siab los tua Wilms qog hlwb.
Dab tsi zoo sib xws ntawm Neuroblastoma thiab Wilms Tumor?
- Neuroblastoma thiab Wilms qog yog ob hom mob qog noj ntshav thaum yau.
- Ob qho xwm txheej cuam tshuam rau menyuam yaus hnub nyoog qis dua 5 xyoos.
- Ob qho xwm txheej no tsis tshua muaj rau cov menyuam yaus hnub nyoog qis dua 5 xyoos.
- Lawv muaj cov kev kuaj mob zoo sib xws.
- Yog tau txais, ob qho tib si ua raws li tus qauv autosomal dominant qub txeeg qub teg.
- Lawv yog cov mob kho tau.
Qhov txawv ntawm Neuroblastoma thiab Wilms Tumor yog dab tsi?
Neuroblastoma yog cov qog nqaij hlav extracranial tshaj plaws nyob rau hauv thaum yau thiab feem ntau tshwm sim hauv cov qog adrenal thaum Wilms qog yog cov mob raum loj tshaj plaws hauv menyuam yaus thiab feem ntau tshwm sim hauv ob lub raum. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm neuroblastoma thiab Wilms qog. Tsis tas li ntawd, neuroblastoma yog tshwm sim los ntawm kev hloov pauv hauv ALK lossis PHOX2B noob. Ntawm qhov tod tes, Wilms qog yog tshwm sim los ntawm kev hloov pauv hauv WT1, CTNNB1, lossis AMER1 noob.
Cov duab hauv qab no nthuav tawm qhov sib txawv ntawm neuroblastoma thiab Wilms qog nyob rau hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Neuroblastoma vs Wilms Tumor
Neuroblastoma thiab Wilms qog yog ob hom mob qog noj ntshav thaum yau uas cuam tshuam rau menyuam yaus hnub nyoog qis dua 5 xyoos. Neuroblastoma yog cov qog hlav extracranial tshaj plaws nyob rau hauv menyuam yaus uas feem ntau tshwm sim hauv cov qog adrenal thaum Wilms qog yog cov qog ua rau lub raum hauv menyuam yaus uas feem ntau tshwm sim hauv ob lub raum. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm neuroblastoma thiab Wilms qog.
