Qhov sib txawv tseem ceeb ntawm glucocorticoid thiab mineralocorticoids yog tias glucocorticoids tuaj yeem pab kho qhov txhab thiab txo qhov mob ntawm qhov raug mob, thaum mineralocorticoids tsis tuaj yeem kho qhov txhab lossis txo qhov mob; Hloov chaw, lawv cuam tshuam cov ntsev thiab dej sib npaug hauv peb lub cev.
Glucocorticoids, mineralocorticoids, thiab kev sib deev steroids yog hom steroid hormones peb tuaj yeem paub qhov txawv ntawm cov receptors tshwj xeeb, lub hom phiaj hlwb, thiab cov teebmeem.
Glucocorticoid yog dab tsi?
Glucocorticoid yog ib hom corticosteroid uas khi rau cov glucocorticoid receptor tam sim no nyob rau hauv feem ntau vertebrate tsiaj hlwb. Nws poob rau hauv chav kawm ntawm steroid hormones. Lub npe glucocorticoid los ntawm nws lub luag haujlwm hauv kev tswj cov piam thaj metabolism. Cov corticosteroids no yog ib feem ntawm cov tswv yim tawm tswv yim ntawm lub cev tiv thaiv kab mob. Nws tuaj yeem txo qee yam ntawm kev tiv thaiv kab mob, suav nrog kev mob. Yog li ntawd, glucocorticoids muaj txiaj ntsig zoo hauv kev tsim tshuaj los kho cov kab mob uas los ntawm lub cev tsis muaj zog, piv txwv li, kev ua xua, mob hawb pob, kab mob autoimmune, thiab sepsis..
Daim duab 01: Cov Qauv Tshuaj ntawm Glucocorticoid Molecule
Tsis tas li ntawd, glucocorticoids muaj cov teebmeem pleiotropic thiab suav nrog cov teebmeem tshwm sim, ua rau lawv tsis tshua muag hauv lub txee. Cov tshuaj no tuaj yeem cuam tshuam nrog cov txheej txheem txawv txav hauv cov qog nqaij hlav cancer. Yog li ntawd, peb tuaj yeem siv lawv ntau npaum li cas los kho mob qog noj ntshav.
Ntxiv rau, glucocorticoids tuaj yeem cuam tshuam cov hlwb los ntawm kev khi ntawm glucocorticoid nrog glucocorticoid receptor. Qhov no ua rau ib qho nyuaj ntawm glucocorticoid-glucocorticoid receptors, uas yog tswj los ntawm kev qhia ntawm cov tshuaj tiv thaiv kab mob hauv cov nucleus. Qhov no kuj tseem txwv tsis pub muaj cov kab mob proinflammatory hauv cytosol los ntawm kev tiv thaiv kev hloov pauv ntawm lwm yam kev hloov pauv uas muaj nyob hauv cytosol rau hauv lub nucleus.
Mineralocorticoid yog dab tsi?
Mineralocorticoids yog ib hom corticosteroids uas tsim nyob rau hauv lub adrenal cortex. Cov tshuaj hormones no tuaj yeem cuam tshuam cov ntsev thiab dej sib npaug hauv lub cev. Lub hom phiaj tseem ceeb ntawm mineralocorticoid yog aldosterone. Txawm li cas los xij, muaj ntau yam mineralocorticoids paub, suav nrog progesterone thiab deoxycorticosterone.
Daim duab 02: Cov Qauv Tshuaj ntawm Mineralocorticoid
Feem ntau, aldosterone ua rau lub raum, muab cov khoom siv rov qab los ntawm sodium. Nws kuj tseem cuam tshuam nrog cov dej reabsorption passive thiab tso tawm ntawm cov poov tshuaj hauv cov cell loj ntawm cortical sau tubule. Nws kuj tseem koom nrog hauv kev tawm dag zog ntawm protons los ntawm proton ATPases hauv lumina membrane ntawm intercalated hlwb ntawm peb cov tubule sau. Nyob rau hauv lem, qhov no yuav ua rau kom ntshav siab thiab ntshav ntim.
Qhov txawv ntawm Glucocorticoid thiab Mineralocorticoid yog dab tsi?
Y A glucocorticoid yog ib hom corticosteroid uas khi rau cov glucocorticoid receptor tam sim no nyob rau hauv feem ntau vertebrate tsiaj hlwb. Ib tug mineralocorticoid yog ib hom corticosteroid uas tsim nyob rau hauv lub adrenal cortex. Qhov sib txawv tseem ceeb ntawm glucocorticoid thiab mineralocorticoids yog tias glucocorticoids tuaj yeem pab kho qhov txhab thiab txo qhov mob ntawm qhov raug mob, thaum mineralocorticoids tsis tuaj yeem kho qhov txhab lossis txo qhov mob; Hloov chaw, lawv cuam tshuam cov ntsev thiab dej sib npaug hauv peb lub cev.
Cov ntawv qhia hauv qab no qhia qhov sib txawv ntawm glucocorticoid thiab mineralocorticoid hauv daim ntawv teev npe rau ib sab ntawm kev sib piv.
Summary – Glucocorticoid vs Mineralocorticoid
Glucocorticoids, mineralocorticoids, thiab kev sib deev steroids yog hom steroid hormones uas peb tuaj yeem yooj yim paub qhov txawv ntawm cov receptors tshwj xeeb, lub hom phiaj hlwb, thiab cov teebmeem. Qhov sib txawv tseem ceeb ntawm glucocorticoid thiab mineralocorticoids yog tias glucocorticoids tuaj yeem pab kho qhov txhab thiab txo qhov mob ntawm qhov raug mob, thaum mineralocorticoids tsis tuaj yeem kho qhov txhab lossis txo qhov mob; Hloov chaw, lawv cuam tshuam cov ntsev thiab dej sib npaug hauv peb lub cev.
