Qhov sib txawv tseem ceeb ntawm oncogenes thiab oncoprotein yog cov oncogenes yog cov qog nqaij hlav qog nqaij hlav tsim los ntawm kev hloov lossis hloov pauv hauv DNA theem ntawm proto-oncogene thaum oncoprotein yog cov protein coded los ntawm oncogene uas yog lub luag haujlwm rau lub cell uas tswj tsis tau. division.
Cells faib thiab tsim cov hlwb tshiab ntawm cov voj voog ntawm tes. Lub voj voog ntawm tes yog cov txheej txheem tswj tau zoo, thiab ntau hom kev tswj hwm cov protein tau koom nrog hauv cov txheej txheem no. Cov kev cai tswj hwm cov protein no yog coded los ntawm cov noob hu ua proto-oncogenes. Proto-oncogenes yog cov noob ib txwm siv rau kev tswj hwm lub voj voog ntawm tes zoo. Ntau lab lab ntawm cov hlwb muaj sia pib, faib, thiab tuag raws li kev tswj hwm hauv cov kab mob muaj sia. Kev tswj hwm cov proteins uas tau tsim los ntawm proto-oncogenes koom ua ke tag nrho cov xwm txheej no zoo kawg nkaus hauv cov hlwb. Yog li, proto-oncogenes yog cov noob tseem ceeb heev hauv cov cell nyob. Txawm li cas los xij, proto-oncogenes tuaj yeem hloov mus rau hauv oncogenes vim kev hloov pauv. Oncogenes yog cov qog nqaij hlav cancer. Cov noob no tsim cov protein sib txawv hu ua oncoproteins. Oncoproteins yog lub luag haujlwm rau kev loj hlob ntawm tes.
Dab tsi yog Oncogenes?
Oncogenes yog cov noob muaj lub luag haujlwm rau kev txhim kho qog noj ntshav. Mob qog noj ntshav yog tshwm sim los ntawm kev tswj tsis tau ntawm tes. Thaum DNA ib ntus ntawm proto-oncogene hloov pauv lossis hloov pauv, oncogenes raug tsim. Proto-oncogenes dhau los ua oncogenes vim muaj ntau yam kev hloov pauv caj ces lossis cov txheej txheem xws li kev hloov pauv, kev nthuav dav ntawm noob, thiab kev hloov pauv chromosomal.
Daim duab 01: Oncogene
Thaum oncogenes tau nthuav tawm, lawv tsim oncoproteins, uas cuam tshuam thiab cuam tshuam lub voj voog ntawm tes. Oncogenes tsim inhibitors ntawm lub voj voog ntawm tes uas ua rau cov hlwb sib faib tsis tu ncua txawm tias thaum lub sijhawm tsis zoo rau kev faib cell. Lawv kuj tsim cov kev tswj xyuas zoo uas ua kom cov hlwb ua haujlwm kom txog thaum tsim cov qog nqaij hlav. Oncogenes ua haujlwm rau kev tsim mob qog noj ntshav los ntawm kev txhawb nqa kev faib tawm ntawm tes tsis muaj kev tswj hwm, txo qis kev sib txawv ntawm tes, thiab inhibiting programmed cell tuag (apoptosis). Qee cov tib neeg feem ntau muaj cov proto-oncogenes hloov mus rau oncogenes thiab tsim cov qog nqaij hlav vim yog cov kab mob qog noj ntshav xws li hluav taws xob, kab mob, thiab cov co toxins.
Oncoprotein yog dab tsi?
Oncoprotein yog ib yam khoom ntawm oncogene. Hauv lwm lo lus, oncogenes synthesize oncoproteins. Oncoproteins yog ntau hom proteins uas muaj lub luag haujlwm rau kev loj hlob ntawm tes. Lawv ua rau muaj mob qog noj ntshav thiab mob congenital. Oncoporteins txhawb kev hloov pauv ntawm cov cell mus rau hauv cov qog. Nws yog ua los ntawm dysregulating cov kev taw qhia txoj kev koom tes nyob rau hauv cell loj hlob, faib, thiab tuag.
Daim duab 02: Oncoprotein - Human Papillomavirus Oncoprotein E6
Piv txwv ntawm peb tus kab mob oncoproteins yog SV40 loj T antigen, adenovirus E1A, thiab tib neeg papillomavirus E7. Peb cov oncoproteins no muaj peev xwm ua kom cov hlwb quiescent rov nkag mus rau lub voj voog ntawm tes. Txij li thaum muaj oncoproteins qhia txog kev txhim kho qog noj ntshav, qee cov oncoproteins tau siv los ua cov cim qog. Ntau cov tshuaj tiv thaiv kab mob tsom rau oncoproteins.
Dab tsi zoo sib xws ntawm Oncogenes thiab Oncoprotein?
- Oncogenes code rau oncoproteins.
- Ob leeg oncogenes yog oncoproteins yog lub luag haujlwm rau kev loj hlob ntawm tes.
- Cov oncogenes thiab oncoproteins tswj lub voj voog ntawm tes tsis zoo.
Qhov txawv ntawm Oncogenes thiab Oncoprotein yog dab tsi?
Oncogene yog ib qho qog-inducing noob tsim vim muaj kev hloov pauv uas tshwm sim hauv proto-oncogene. Oncoprotein yog cov khoom tsim los ntawm oncogene. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm oncogenes thiab oncoprotein. Ntxiv mus, oncogenes yog tsim los ntawm nucleic acids, thaum oncoproteins yog cov proteins ua los ntawm cov amino acids.
Cov infographic hauv qab no teev qhov sib txawv ntawm oncogenes thiab oncoprotein nyob rau hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Oncogenes vs Oncoprotein
Proto-oncogenes yog cov noob ib txwm tswj hwm kev faib tawm ntawm tes. Protooncogenes code zoo cell voj voog regulator proteins uas yog ib qho tseem ceeb rau ib txwm cell faib. Proto-oncogenes dhau los ua oncogenes los ntawm kev hloov pauv lossis overexpression. Oncogene yog ib hom qog nqaij hlav los yog qog nqaij hlav cancer. Oncoprotein yog cov protein tshwm sim ntawm oncogene. Oncoproteins txhawb kev hloov pauv ntawm cov hlwb ib txwm ua rau cov qog nqaij hlav cancer. Yog li, qhov no yog cov ntsiab lus ntawm qhov sib txawv ntawm oncogenes thiab oncoprotein.
