Qhov sib txawv tseem ceeb ntawm liposomes thiab niosomes yog liposomes yog cov hlwv xa khoom ua los ntawm concentric bilayer ntawm lipids, thaum niosomes xa cov vesicles ua los ntawm surfactants nrog lossis tsis koom nrog cov roj cholesterol.
Kev xa tshuaj yog txhais tias yog kev thauj khoom ntawm ib qho chaw tshuaj rau nws lub hom phiaj kom ua tiav cov txiaj ntsig kho mob xav tau. Nws suav nrog txoj hauv kev, kev tsim qauv, kev tsim khoom, cov tshuab khaws cia thiab lwm yam thev naus laus zis tseem ceeb rau kev xa cov tshuaj sib txuas. Cov kev siv zog tam sim no hauv kev xa tshuaj muaj ntau dua thiab koom nrog thaj chaw xws li kev xa tshuaj tam sim no yog tswj kev tso tawm cov qauv, kev xa tawm, nanomedicine, cov neeg nqa tshuaj, 3D luam ntawv, xa cov tshuaj lom neeg. Liposomes thiab niosomes yog ob hom kev xa khoom vesicles uas tam sim no siv los xa cov tshuaj thiab lwm yam sib txuas rau cov chaw phiaj xwm.
Liposomes yog dab tsi?
Liposomes yog cov hlwv xa khoom ua los ntawm concentric bilayers ntawm lipids. Liposomes yog lub tsheb xa tshuaj siv rau kev tswj hwm cov khoom noj thiab tshuaj tshuaj. Ib qho piv txwv zoo ntawm liposomes yog lipid nanoparticles hauv cov tshuaj tiv thaiv mRNA thiab cov tshuaj tiv thaiv DNA. Liposomes tau pom thawj zaug los ntawm British hematologist Alec. D. Bangham xyoo 1961 ntawm Babraham Institute, Cambridge.
Daim duab 01: Liposomes
Liposomes tuaj yeem npaj los ntawm kev cuam tshuam cov kab mob lom neeg los ntawm sonication. Feem ntau liposomes muaj phospholipids, tshwj xeeb tshaj yog phosphatidylcholine. Lawv kuj tseem muaj lipids zoo li qe phosphatidylethanolamine. Tsis tas li ntawd, liposomes tuaj yeem siv cov ligands rau txuas rau cov ntaub so ntswg tsis zoo. Muaj plaub chav kawm loj ntawm liposomes: multilamellar vesicle (MLV), me me unilamellar liposome vesicle (SUV), loj unilamellar vesicle (LUV), thiab chochleate vesicle. Ib tug liposome tsim muaj ib tug aqueous tov core puag ncig los ntawm ib tug hydrophobic lipid bilayer. Hydrophilic solutes tuaj yeem yaj hauv cov tub ntxhais aqueous, thiab cov kua dej no tsis tuaj yeem dhau los ntawm bilayer. Ntawm qhov tod tes, cov tshuaj hydrophobic ncaj qha koom nrog bilayers. Yog li, liposomes tuaj yeem xa ob qho tib si hydrophilic thiab hydrophobic molecules. Tsis tas li ntawd, tsis yog kev xa tshuaj, liposomes yog tam sim no siv rau kev xa qhov ncauj ntawm qee yam khoom noj thiab khoom noj khoom haus.
Niosomes yog dab tsi?
Niosomes yog xa cov hlwv uas ua los ntawm cov tshuaj surfactants nrog lossis tsis muaj cov roj cholesterol uas tuaj yeem siv rau kev xa tshuaj thiab lwm cov tshuaj. Cov roj (cholesterol) yog ib qho ntxiv hauv niosomes. Tab sis lwm cov tshuaj ntxiv kuj tuaj yeem siv tau dua li cov roj cholesterol. Feem ntau, niosomes muaj peev xwm nkag tau ntau dua. Txawm hais tias lawv zoo ib yam li liposomes, cov ntaub ntawv siv los npaj niosomes ua rau lawv ruaj khov dua. Lawv tuaj yeem nkag tau ob qho tshuaj hydrophilic thiab lipophilic thiab xa mus rau cov chaw phiaj xwm.
Daim duab 02: Niosomes
Kev tsim qauv, niosomes muaj cov tsis-ionic surfactants ntawm alkyl lossis dialkyl polyglycerol ether thiab cov roj cholesterol, uas yog hydrated tom qab hauv cov xov xwm aqueous. Niosomes muaj kev sib raug zoo nrog cov kab mob lom thiab tsis muaj tshuaj lom. Ntxiv mus, lawv yog biodegradable thiab non-immunogenic. Tsis tas li ntawd, niosomes nkag cov tshuaj lipophilic rau hauv lawv cov vesicular bilayer daim nyias nyias thiab cov tshuaj hydrophilic rau hauv cov dej hauv dej.
Dab tsi yog qhov zoo sib xws ntawm Liposomes thiab Niosomes?
- Liposomes thiab niosomes yog ob lub membranous vesicles.
- Ob leeg tuaj yeem xa cov tshuaj thiab cov khoom noj rau lub hom phiaj.
- Cov no yog ua los ntawm cov dej hydrophobic bilayer thiab cov tub ntxhais hydrophilic.
- Ob leeg yog tsim los ntawm cov khoom siv biocompatible thiab biodegradable.
- Lawv tsis yog tshuaj tiv thaiv kab mob thiab txo cov tshuaj toxicity.
Qhov txawv ntawm Liposomes thiab Niosomes yog dab tsi?
Liposomes yog xa cov hlwv ua los ntawm concentric bilayer ntawm lipids, thaum niosomes yog xa vesicles ua los ntawm surfactants nrog los yog tsis muaj cov cholesterol. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm liposomes thiab niosomes. Tsis tas li ntawd, qhov loj ntawm liposomes nyob ntawm 10-3000 nm, thaum qhov loj ntawm niosomes nyob ntawm 10-100nm. Yog li, qhov no yog lwm qhov sib txawv ntawm liposomes thiab niosomes.
Cov kab ntawv hauv qab no qhia ntau qhov sib txawv ntawm liposomes thiab niosomes.
Summary – Liposomes vs Niosomes
Liposomes thiab niosomes yog siv rau hauv ntau yam kev tshawb fawb rau kev xa tshuaj thiab hloov cov noob. Qhov sib txawv tseem ceeb ntawm liposomes thiab noisomes yog tias liposomes yog cov hlwv xa khoom los ntawm concentric bilayer ntawm lipids, whereas niosomes yog xa cov vesicles ua los ntawm surfactants nrog lossis tsis koom nrog cov roj cholesterol.
