Qhov sib txawv tseem ceeb ntawm interleukin 1 thiab 2 yog tias interleukin 1 yog cytokine uas yog lub luag haujlwm tseem ceeb rau kev tswj hwm tus mob thiab mob ntev thaum interleukin 2 yog cytokine uas yog lub luag haujlwm tseem ceeb rau kev loj hlob thiab kev sib txawv ntawm T hlwb.
Interleukins yog ib hom cytokines uas tsim los ntawm ntau lub cev hlwb. Lawv yog cov proteins secreted nyob rau hauv teb rau pathogens thiab lwm yam antigens. Muaj ntau tshaj 50 interleukins thiab lwm yam proteins coded los ntawm tib neeg genome. Lawv muaj peev xwm khi nrog cell receptors pom nyob rau saum npoo. Interleukins ua lub luag haujlwm tseem ceeb hauv kev ua kom thiab sib txawv ntawm lub cev tiv thaiv kab mob. Ntxiv mus, lawv muaj pro thiab anti-inflammatory zog. Yog li ntawd, lawv yog ib feem tseem ceeb ntawm inflammatory teb ntawm lub cev tiv thaiv kab mob. Interleukin 1 thiab 2 yog ob tsev neeg loj ntawm interleukins. Lawv yog lub luag haujlwm tseem ceeb rau kev ua kom T thiab B lymphocytes.
Interleukin 1 yog dab tsi?
Interleukin 1 tsev neeg (IL-1) yog ib pawg ntawm 11 cytokines. Muaj ob tug neeg kawm feem ntau ntawm interleukin1. Lawv yog interleukin 1 alpha thiab interleukin 1 beta (IL1 alpha thiab IL1 beta). Lawv khi nrog tib lub receptor: hom I IL-1 receptor (IL-1RI). Ob leeg IL-1α thiab IL-1β qhia tau hais tias muaj zog pro-inflammatory nyhuv. Cov hlwb sib txawv, suav nrog cov macrophages, cov lymphocytes loj, B hlwb, endothelium, fibroblasts, thiab astrocytes secrete IL-1.
Daim duab 01: Interleukin 1
Lub hom phiaj tseem ceeb ntawm IL-1 yog T hlwb, B hlwb, macrophages, fibroblasts, dendritic hlwb, endothelial thiab cov ntaub so ntswg. Lub luag haujlwm tseem ceeb ntawm IL-1 yog lymphocyte activation, macrophage stimulation, nce leukocyte / endothelial adhesion, kub taub hau vim hypothalamus stimulation, tso tawm ntawm mob-theem proteins los ntawm lub siab, apoptosis nyob rau hauv ntau hom cell thiab cachexia.
Interleukin 2 yog dab tsi?
Interleukin 2 (IL-2) yog cytokine signaling molecule ua los ntawm activated T hlwb. Raws li txoj cai, nws yog 15.5-16 kDa protein uas khi nrog IL-2 receptors ntawm lymphocytes. IL-2 feem ntau tswj cov kev ua ub no ntawm cov qe ntshav dawb mediating kev sib cuam tshuam ntawm cov hlwb. Lub hom phiaj tseem ceeb ntawm IL-2 yog T hlwb thiab IL-2 yog qhov tsim nyog rau kev loj hlob, kev loj hlob, thiab kev sib txawv ntawm naïve T cells rau hauv effector T cells. Yog li, IL-2 yog thawj zaug txhais tias yog T cell loj hlob yam.
Daim duab 02: Interleukin 2
Lub luag haujlwm tseem ceeb ntawm IL-2 yog T-cell proliferation thiab sib txawv, nce cytokine synthesis, potentiating Fas-mediated apoptosis, thiab txhawb kev tswj T cell. Tsis tas li ntawd, nws cuam tshuam rau kev loj hlob thiab kev ua kom lub ntuj tua cov hlwb thiab B-cell proliferation thiab antibody synthesis. Tsis tas li ntawd, IL-2 txhawb kev ua haujlwm ntawm cytotoxic lymphocytes thiab macrophages. IL-2 feem ntau kawm txog kev kho mob qog noj ntshav. Nws tau siv rau hauv kev kho mob ntawm metastatic lub raum cell carcinoma thiab metastatic melanoma. IL-2 tau siv hauv kev sib xyaw ua ke feem ntau nrog interferons.
Dab tsi yog qhov Zoo sib xws ntawm Interleukin 1 thiab 2?
- Interleukin 1 thiab 2 yog cytokine signaling molecules hauv lub cev tiv thaiv kab mob.
- Yog li ntawd, lawv muaj lub luag haujlwm tiv thaiv kab mob.
- ob leeg yog cov protein.
- Lawv khi nrog cov xov tooj ntawm tes tshwj xeeb receptors.
Qhov txawv ntawm Interleukin 1 thiab 2 yog dab tsi?
Interleukin 1 yog tsev neeg ntawm interleukin uas muaj 11 cytokines lub luag haujlwm rau kev tswj kev mob. Interleukin 2 yog ib qho cytokine signaling molecule uas txhawb kev loj hlob ntxiv thiab sib txawv ntawm activated T hlwb. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm interleukin 1 thiab 2. Tsis tas li ntawd, IL-1 khi nrog IL-1 receptors thaum IL-2 khi nrog IL-2 receptors. Ntxiv mus, macrophages, loj granular lymphocytes, B hlwb, endothelium, fibroblasts, thiab astrocytes secrete IL-1 thaum T hlwb secrete IL-2.
Hauv qab info-graphic teev qhov sib txawv ntawm interleukin 1 thiab 2 hauv daim ntawv tabular.
Summary – Interleukin 1 vs 2
Interleukin 1 thiab 2 yog cov tswvcuab kawm ntau tshaj plaws ntawm cytokines. Interleukin 1 yog ib tsev neeg ntawm cytokines uas muaj zog pro-inflammatory nyhuv. Yog li ntawd, IL-1 feem ntau yog lub luag haujlwm rau kev tswj hwm kev mob hnyav thiab mob ntev. Interleukin 2 yog ib qho cytokine signaling molecule uas tsim los ntawm activated T hlwb. IL-2 txhawb nqa kev loj hlob ntxiv thiab sib txawv ntawm cov kab mob T hlwb. Ob leeg IL-1 thiab IL-2 yog lub luag haujlwm rau kev tiv thaiv kab mob hauv lub cev thiab yoog raws. Lawv ua lub luag haujlwm tseem ceeb hauv kev tawm tsam mob qog noj ntshav, kab mob sib kis thiab lwm yam kab mob. Yog li, qhov no qhia txog qhov sib txawv ntawm interleukin 1 thiab 2.
