Qhov sib txawv tseem ceeb ntawm CCR5 thiab CXCR4 yog lawv lub luag haujlwm hauv kev kis tus kabmob HIV. Thaum lub sij hawm ntxov ntawm tus kab mob HIV, cov kab mob sib cais zoo li siv CCR5 rau kev kis kab mob; Yog li M-tropic kab mob kis tau zoo tshaj plaws thaum lub sijhawm ntxov ntawm kev kis kab mob. Hauv qhov sib piv, cov kev sib cais tom qab yuav siv CXCR4 rau kev nkag mus kis kab mob; yog li cov kab mob T-tropic tshwm sim lig thaum lub sij hawm kis kab mob mus rau AIDS.
tus kab mob HIV siv CD4 cell ua tus thawj receptor rau nkag mus rau tib neeg lub hlwb. Tsis tas li ntawd, CCR5 thiab CXCR4 yog ob hom chemokine receptors uas tau siv los ua coreceptors hauv HIV-1 nkag. Yog li, qhov kev qhia ntawm cov coreceptors no yog qhov tseem ceeb rau kev txiav txim siab kis kab mob.
Ntau hom kab mob HIV-1 siv ob lub coreceptors no. CXCR4 thiab CCR5 sawv cev rau tus qauv coreceptors rau kev nkag ntawm T-tropic thiab M-tropic HIV-1 hom, raws li. Feem ntau, cov kab mob sib cais siv CCR5 coreceptors thaum lub sijhawm ntxov ntawm tus kab mob HIV thaum tom qab cais tawm siv CXCR4 coreceptors. Thaiv cov CCR5 thiab CXCR4 coreceptors yog ib txoj hauv kev tiv thaiv HIV los ntawm kev kis kab mob tshiab. Yog li, cov kws tshawb fawb tab tom tsim txoj hauv kev los thaiv cov chaw receptor ncaj qha.
CCR5 yog dab tsi?
CCR5 yog chemokine coreceptor uas yog xya-transmembrane G-protein coupled receptor. Nws yog hydrophobic protein uas tsis tuaj yeem ntxuav tau yooj yim. CCR5 coreceptor muaj nyob rau ntawm ntau lub hlwb, suav nrog T-cells thiab macrophages. Muaj xya qhov chaw phosphorylation hauv CCR5. CCR5 tso cai nkag rau M-tropic HIV-1 hom. M-trophic lossis macrophage-tropic HIV hom kab mob feem ntau tshwm sim thaum ntxov, thiab cov kab mob no nyiam siv CCR5 coreceptors rau kis kab mob. M-trophic HIV hom kab mob yog hom kab mob sib deev tshaj plaws ntawm tus kab mob. Yog li ntawd, CCR5 zoo li tseem ceeb rau M-trophic hom.
Daim duab 01: CCR5 Coreceptor
CXCR4 yog dab tsi?
Zoo ib yam li CCR5, CXCR4 yog cov tshuaj chemokine coreceptor uas txhawb nqa HIV-1 nkag mus rau hauv tib neeg lub hlwb. Nws tseem yog xya-transmembrane G-coupled receptor. CXCR4 coreceptors feem ntau pom ntawm CD4 + hlwb. Muaj 21 qhov chaw phosphorylation hauv CXCR4.
Daim duab 02: CXCR4 Coreceptor
T-trophic HIV kab mob uas pom thaum lub sijhawm kis kab mob siv CXCR4 coreceptors. CXCR4 yog encoded los ntawm CXCR4 gene.
Dab tsi yog qhov zoo sib xws ntawm CCR5 thiab CXCR4?
- CCR5 thiab CXCR4 yog HIV coreceptors.
- Ob leeg yog cov tshuaj chemokine receptors nyob rau saum npoo ntawm cov qe ntshav dawb.
- Lawv tau qhib los ntawm kev khi ntawm ib lossis ntau dua chemokines.
- Structurally, lawv yog xya-transmembrane G-protein coupled receptors.
- Lawv ua haujlwm ua coreceptors rau HIV-1 nkag rau hauv CD4+ hlwb.
- Muaj CCR5 thaiv cov neeg ua haujlwm thiab CXCR4-raws li thaiv cov neeg ua haujlwm.
- Ob leeg CCR5 thiab CXCR4 cov proteins yog cov hydrophobic heev thiab tsis tuaj yeem ntxuav tau yooj yim.
Qhov txawv ntawm CCR5 thiab CXCR4 yog dab tsi?
CCR5 yog chemokine coreceptor uas tso cai rau nkag mus ntawm M-trophic HIV kab mob rau hauv tib neeg lub hlwb thaum CXCR4 yog chemokine coreceptor uas txhawb kev nkag mus ntawm T-tropic HIV-1 hom rau hauv tib neeg lub hlwb. M-trophic HIV hom siv CCR5 coreceptors rau tus kab mob nkag mus rau thaum ntxov ntawm tus kab mob kis thaum kis kab mob T-trophic HIV siv CXCR4 coreceptors rau kis kab mob thaum lub sijhawm kis kab mob. Yog li, qhov no yog qhov txawv ntawm CCR5 thiab CXCR4.
Hauv qab infographic qhia ntau cov ntsiab lus ntawm qhov sib txawv ntawm CCR5 thiab CXCR4.
Summary – CCR5 vs CXCR4
CCR5 thiab CXCR4 yog ob lub proteins uas tau hais tawm rau saum npoo ntawm lub cev tiv thaiv kab mob. Lawv yog tsev neeg ntawm xya transmembrane G-protein-coupled chemokine receptors. Ob lub receptors no ua raws li coreceptors rau HIV nkag mus rau hauv tib neeg lub hlwb. M-trophic HIV hom siv CCR5 coreceptors rau tus kab mob nkag mus rau thaum ntxov ntawm tus kab mob kis thaum kis kab mob T-trophic HIV siv CXCR4 coreceptors rau tus kab mob nkag mus thaum lub sijhawm kis kab mob. Ob leeg coreceptors yog qhib los ntawm kev khi ntawm ib lossis ntau dua chemokines. Yog li, qhov no qhia txog qhov sib txawv ntawm CCR5 thiab CXCR4.
