Qhov sib txawv tseem ceeb ntawm HIF-1 thiab HIF-2 yog qhov hypoxia-inducible factor 1 lossis HIF-1 yog lub ntsiab tswj cov lus teb rau hypoxia thaum HIF-2 yog qhov tseem ceeb ntawm kev cuam tshuam thiab metastasis hauv ntau yam. qog.
Hypoxia yog ib yam mob uas cov ntaub so ntswg tsis tau txais oxygen txaus. Nws tshwm sim vim qhov tsis txaus oxygen concentration hauv cov ntshav. Nws yog ib qho mob hnyav uas tuaj yeem ua rau ntau yam tsos mob, suav nrog ua tsis taus pa, ua tsis taus pa, mob taub hau, tsis meej pem lossis tsis xis nyob thiab tuaj yeem ua rau coma lossis tuag. Muaj cov xwm txheej hypoxia-inducible (HIF). Lawv yog cov kev hloov pauv uas yog heterodimer complexes. Lawv muaj ib qho inducible alpha (α) subunit thiab constitutively qhia beta (β) subunits. HIF-1, HIF-2 thiab HIF-3 yog peb qhov kev hloov pauv. Ntawm lawv, HIF-1 thiab HIF-2 yog cov tswj hwm ntawm oxygen homeostasis. Ob leeg yog heterodimeric transcription yam tseem ceeb kho cov cellular teb rau hypoxia.
HIF-1 yog dab tsi?
Hypoxia-inducible factor 1 lossis HIF-1 yog qhov tseem ceeb ntawm kev hloov pauv. Nws yog ib qho heterodimeric molecule tsim los ntawm alpha subunit thiab beta subunit. Nws yog ib qho yooj yim helix-loop-helix qauv. Tib neeg HIF1A noob encodes rau alpha subunit. HIF-1 feem ntau kho cov cellular teb rau hypoxia. Qhov tseeb, HIF-1 yog tus tswj hwm ntawm oxygen homeostasis. Nws tswj cov pa oxygen noj thiab hloov morphologically teb rau qhov sib txawv ntawm cov pa oxygen.
Daim duab 01: HIF-1
Ntxiv rau kev tswj hwm cov pa homeostasis, HIF-1 induces transcription ntawm ntau tshaj 60 noob, nrog rau VEGF, erythropoietin, cell proliferation thiab ciaj sia taus, nrog rau cov piam thaj thiab hlau metabolism.
HIF-2 yog dab tsi?
HIF-2 yog ib tus tswv cuab ntawm heterodimeric transcription yam uas yog hypoxia-inducible yam. Zoo ib yam li HIF-1, HIF-2 yog tsim los ntawm alpha subunit thiab beta subunit. Zoo ib yam li HIF-1, HIF-2 yog tus tswj hwm ntawm oxygen homeostasis. Ntxiv mus, HIF-2 tswj erythropoietin ntau lawm hauv cov neeg laus. Tsis tas li ntawd, HIF-2 yog ib qho kev txiav txim siab tseem ceeb ntawm kev cuam tshuam thiab metastasis hauv ntau cov qog.
Daim duab 02: Yuav ua li cas Cells Sense thiab hloov mus rau Oxygen Muaj
HIF2α tau nthuav tawm ntau dhau hauv cov qog, suav nrog mob qog noj ntshav. HIF-2 cuam tshuam nrog cov theem kho mob qog noj ntshav uas cuam tshuam rau kev loj hlob, cuam tshuam thiab metastasis. Nws siv cov haujlwm sib txawv thaum lub sijhawm tsim cov qog nqaij hlav.
Qhov Zoo sib xws ntawm HIF-1 thiab HIF-2 yog dab tsi?
- HIF-1 thiab HIF-2 yog heterodimeric transcription yam uas yog isoforms.
- Ob leeg yog tsim los ntawm alpha thiab beta subunits.
- Ob leeg qhib HRE-dependent gene transcription.
- Lawv yog cov tswj hwm ntawm oxygen homeostasis.
- Lawv kho kom haum xeeb cov lus teb ntawm tes rau hypoxia.
- Post-translational kev cai ntawm α-subunit tswj kev ruaj ntseg thiab transactivation ntawm HIF-1 thiab HIF-2.
- Kev qhia siab ntawm HIF-1 thiab HIF-2 yog qhov tseem ceeb ntawm ntau tus neeg mob qog noj ntshav.
- Lawv txhawb cov txheej txheem ntawm tes, uas ua rau cov qog nqaij hlav zuj zus.
- Ob leeg HIF-1 thiab HIF-2 khi rau tib lub hypoxia- teb cov ntsiab lus DNA pom zoo ib ntus hauv cov hom phiaj txhawb nqa.
Qhov txawv ntawm HIF-1 thiab HIF-2 yog dab tsi?
HIF-1 yog tus tswj hwm lub ntsiab ntawm cov lus teb rau hypoxia thaum HIF-2 yog qhov tseem ceeb ntawm kev cuam tshuam thiab metastasis hauv ntau cov qog. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm HIF-1 thiab HIF-2. HIF-1 α thiab HIF-1 β yog ob hom HIF-1 thaum HIF-2 α thiab HIF-2 β yog ob hom HIF-2.
Cov hauv qab no infographic tabulates qhov sib txawv ntawm HIF-1 thiab HIF-2 kom meej ntxiv.
Summary – HIF-1 vs HIF-2
Nyob rau hauv cov mob hypoxia, peb cov ntshav tsis muaj oxygen txaus rau cov ntaub so ntswg kom ua tiav lawv cov kev xav tau. Nws yog ib qho xwm txheej txaus ntshai vim tias tsis muaj oxygen rau cov ntaub so ntswg thiab lub cev tuaj yeem tsim teeb meem loj. HIF-1 thiab HIF-2 yog regulators ntawm oxygen homeostasis. Lawv yog cov kev hloov pauv uas tsim los ntawm α subunits thiab β subunits. Lawv yog cov isoforms. HIF-1 yog lub luag haujlwm tseem ceeb ntawm cov lus teb rau hypoxia thaum HIF-2 yog qhov tseem ceeb ntawm kev cuam tshuam thiab metastasis hauv ntau cov qog. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm HIF-1 thiab HIF-2.
