Qhov sib txawv tseem ceeb ntawm ubiquitination thiab sumoylation yog qhov ubiquitination yog kev hloov pauv tom qab kev txhais lus uas tuaj yeem kos cov proteins rau kev puas tsuaj lossis muaj lwm yam kev hu nkauj thaum sumoylation yog kev hloov pauv tom qab uas tsis yog siv hauv cov hlwb los kos cov proteins rau degradation.
Kev hloov pauv tom qab kev txhais lus yog covalent thiab kev hloov kho enzymatic uas tshwm sim tom qab kev sib txuas ntawm cov protein. Cov kev hloov kho no tswj hwm cov haujlwm protein. Kev sib txuas ntawm cov tshuaj me me, qab zib, lipids thiab polypeptides hloov cov proteins. Ubiquitin yog tus paub zoo tshaj plaws polypeptide hloov kho. Tsis tas li ntawd, muaj ntau cov protein zoo li ubiquitin. Me ubiquitin-related modifier (SUMO) yog ib qho kev hloov kho. Yog li ntawd, ubiquitination thiab suoylation yog ob qho kev hloov kho tom qab kev txhais lus. Ubiquitination marks proteins rau degradation. Hauv kev sib piv, sumoylation tsis yog siv los kos cov proteins rau degradation. Ob qho kev hloov kho tswj cov protein hauv zos thiab kev ua haujlwm. Lawv yog cov txheej txheem thim rov qab.
Ubiquitination yog dab tsi?
Ubiquitin yog tus hloov pauv polypeptide. Nws yog ib qho me me ntawm cov protein ua lub cim molecular hauv kev hloov pauv tom qab kev hloov pauv ntawm cov protein. Ubiquitination yog txheej txheem uas siv ubiquitin rau kev hloov pauv tom qab kev hloov pauv. Cov enzymes sib txawv catalyze covalent conjugation ntawm ubiquitin rau cov proteins. Nws tshwm sim nyob rau hauv lub xub ntiag ntawm ATP. Cov enzymes uas catalyze ubiquitination yog ubiquitin-activating enzymes, ubiquitin-conjugating enzymes thiab ubiquitin ligases.
Daim duab 01: Ubiquitination
Ubiquitination plays lub luag haujlwm tseem ceeb hauv kev tsom cov proteins rau kev degradation proteolytic. Ntxiv mus, ubiquitination tuaj yeem tswj hwm cov protein hauv zos thiab kev ua haujlwm. Cov txheej txheem no tuaj yeem thim rov qab los ntawm kev ua ntawm deubiquitinase enzymes.
SUMOylation yog dab tsi?
SUMOylation yog lwm qhov kev hloov kho tom qab kev txhais lus siv me me ubiquitin-zoo li hloov pauv (SUMOs). Covalent txuas ntawm SUMOs hloov cov qauv thiab kev ua haujlwm ntawm cov protein. SUMOylation covalently hloov kho ntau cov proteins koom nrog hauv ntau cov txheej txheem ntawm tes nrog rau cov noob qhia, chromatin qauv, teeb liab hloov, thiab kev saib xyuas ntawm genome.
Daim duab 02: SUMO Protein
SUMOylation tswj hwm cov protein hauv zos thiab cov haujlwm zoo ib yam li ubiquitination. Txawm li cas los xij, tsis zoo li ubiquitination, suoylation tsis tag lossis cim cov proteins rau degradation. Zoo ib yam li ubiquitination, suoylation yog ib qho kev ua kom muaj zog uas yog catalyzed los ntawm enzymes.
Dab tsi yog qhov zoo sib xws ntawm Ubiquitination thiab SUMOylation?
- Ubiquitination thiab Sumoylation yog ob qho tseem ceeb tom qab kev hloov pauv hloov pauv.
- Ob qho suoylation thiab ubiquitination yog cov txheej txheem thim rov qab.
- Lawv ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm lom neeg.
- Qee cov proteins tuaj yeem hloov kho los ntawm SUMO thiab ubiquitin.
- Ob txheej txheem hloov cov protein ua haujlwm.
- Ntxiv mus, ob qho tib si tom qab kev hloov pauv hloov pauv tswj cov protein hauv zos thiab kev ua si.
- Lawv xav tau cov enzymes cascade.
Qhov txawv ntawm Ubiquitination thiab SUMOylation yog dab tsi?
Ubiquitination thiab SUMOylation yog ob qhov kev hloov pauv tom qab uas hloov pauv cov haujlwm ntawm cov protein. Ubiquitination yog covalent conjugation ntawm ubiquitin rau cov proteins thaum SUMOylation yog qhov sib ntxiv ntawm SUMOs rau cov protein. Ntxiv mus, ubiquitination tags proteins rau proteolytic degradation thaum SUMOylation tsis tag cov proteins rau degradation. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm ubiquitination thiab suoylation.
Hauv qab infographic qhia ntau cov ntsiab lus ntawm qhov sib txawv ntawm ubiquitination thiab suoylation.
Summary – Ubiquitination vs SUMOylation
Ubiquitination thiab suoylation yog ob qho tseem ceeb tom qab kev hloov pauv hloov pauv. Ob leeg yog cov txheej txheem thim rov qab catalyzed los ntawm enzymes. Hauv ubiquitination, ubiquitin yog cov hloov pauv polypeptide thaum nyob hauv sumoylation, SUMOs yog cov hloov pauv. Ubiquitins yog covalently conjugated nrog cov proteins thiab hloov lawv cov qauv thiab kev ua haujlwm. SUMOs tau ntxiv rau cov proteins hauv sumoylation. SUMOylation yog qhov sib piv rau ubiquitylation nyob rau hauv cov nqe lus ntawm cov tshuaj tiv thaiv tswv yim thiab enzyme chav kawm siv. Tab sis, ubiquitination tags proteins rau proteasome-dependent degradation thaum sumoylation tsis koom nrog tagging proteins rau degradation. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm ubiquitination thiab suoylation.
