Qhov sib txawv tseem ceeb ntawm dab noj hnub thiab lub sijhawm latent yog lub sijhawm dab noj hnub yog lub sijhawm ntawm kev sib txuas cov phage proteins thiab nucleic acids hauv lub xov tooj ntawm tes, thaum lub sijhawm latent yog lub sijhawm ntawm kev txhaj tshuaj ntawm cov kab mob genome rau hauv lub cell thiab tus tswv tsev. cell lysis.
A bacteriophage (phage) yog ib qho kev ua haujlwm ntawm cov kab mob hauv lub cev uas kis tau thiab nthuav tawm hauv cov kab mob tshwj xeeb. Cov no tseem hu ua cov kab mob noj vim lawv ua cov kab mob bactericidal. Lub taub hau thiab tus Tsov tus tw complex zoo yog cov feem ntau pom pom los ntawm bacteriophages. Lawv kis tus kab mob tus tswv kom rov tsim dua. Thaum pib ntawm tus kab mob, lawv muab nruj nreem rau ntawm phab ntsa ntawm cov kab mob ntawm cov kab mob uas siv lawv cov receptors saum npoo thiab txhaj lawv cov khoom siv caj ces rau hauv lub cell. Tom qab ntawd lawv cov kab mob tuaj yeem tshwm sim ntawm ob lub voj voog: lytic thiab lysogenic voj voog.
Nyob rau hauv lub voj voog lytic, bacteriophages kis cov kab mob thiab tua cov kab mob sai sai los ntawm lysis. Nyob rau hauv lub voj voog lysogenic, cov khoom siv tshuaj tua kab mob ua ke nrog cov kab mob genome lossis plasmids thiab muaj nyob rau hauv lub xov tooj ntawm tes rau ntau tiam neeg yam tsis tua tus kab mob. Cov txheej txheem kis kab mob ua raws lub sijhawm sib txawv raws li lub sijhawm latent, lub sijhawm dab noj hnub, lub sijhawm nce, thiab lwm yam.
Lub Sijhawm Dab Tsi yog Dab Tsi?
Lub sijhawm dab ntxwg nyoog yog lub sijhawm ntawm kev loj hlob ntawm cov kab mob bacteriophage uas pib thaum pib ntawm lub sijhawm latent thiab xaus rau thawj zaug ntawm tus kab mob tshiab intracellular viral progeny nyob rau hauv lub cell cell. Thaum lub sij hawm dab noj hnub, cov nucleic acids tshiab thiab phage proteins yog synthesized.
Daim duab 01: Lytic Cycle
Lub sijhawm dab noj hnub yog zes nyob rau lub sijhawm latent. Qhov tseeb, cov dab noj hnub yog thawj theem ntawm kev kis kab mob, thiab nws pib hauv thawj ob peb feeb tom qab kis kab mob. Yog li ntawd, thaum lub sij hawm dab noj hnub, cov kab mob tshiab yog synthesized thiab pib assembling. Mature phage progeny tshwm thaum kawg ntawm lub sij hawm dab noj hnub.
Lub Sijhawm Latent yog dab tsi?
Nyob rau hauv kev loj hlob ntawm bacteriophage, lub sij hawm latent yog lub sij hawm ntawm kev txhaj tshuaj los yog uptake ntawm tus kab mob genome rau hauv lub xov tooj ntawm tes kom tso tawm cov kab mob tshiab los ntawm tus tswv tsev cell lysis. Yog li ntawd, lub sij hawm latent pib nrog cov kab mob txuas nrog cov kab mob ntawm phab ntsa. Tom qab ntawd nws txuas mus ntawm ntau theem thiab xaus ntawm qhov taw tes ntawm phage-progeny tso tawm los ntawm lysis ntawm tus tswv tsev kab mob cell. Hauv cov lus yooj yim, lub sijhawm latent yog lub sijhawm ntawm phage induced host cell lysis. Lub sij hawm dab noj hnub yog nyob rau hauv lub sij hawm latent. Thaum lub sij hawm latent lub sij hawm, tus tswv cell yog nyob rau hauv kev tswj ntawm phage protein complex.
Daim duab 02: Lub Sijhawm Tsis Muaj Dab Tsi
Cov txheej txheem tshwj xeeb uas tshwm sim thaum lub sijhawm latent yog;
- hloov chaw ntawm tus kab mob nucleic acid rau hauv cov kab mob cytoplasm los ntawm periplasm
- replication ntawm tus kab mob nucleic acids
- qhia tawm cov kab mob kis tau
- ntim cov kab mob
- maturation of viral particles
- cuam tshuam ntawm tus tswv tsev cell membrane, thiab
- tso tawm tus kab mob progeny.
Lub sijhawm latent txawv ntawm cov kab mob sib txawv. Lub sijhawm latent ntawm T4 thiab E. coli yog 20 feeb thaum nws yog 50 feeb rau λ thiab E. coli. Ib yam li ntawd, lub sijhawm latent txawv ntawm phage systems, thiab nws tau cuam tshuam los ntawm tus tswv tsev physiology ib yam nkaus.
Dab tsi zoo sib xws ntawm dab noj hnub thiab lub sijhawm latent?
- Dab noj hnub thiab lub sijhawm latent yog ob lub sijhawm ntawm phage lytic voj voog.
- Qhov tseeb, lub sijhawm dab noj hnub yog ib feem ntawm lub sijhawm latent.
- Ob lub sijhawm yog cuam tshuam los ntawm tus tswv tsev physiology.
Dab tsi yog qhov txawv ntawm Dab Ntxwg Nyoog thiab Lub Sijhawm Latent?
Lub sijhawm dab ntxwg nyoog yog ib feem ntawm lub sijhawm latent uas cov phage tshiab thiab nucleic acids tau tsim nyob rau hauv lub tswv tsev cell. Ntawm qhov tod tes, lub sijhawm latent yog lub sijhawm ntawm kev txhaj tshuaj ntawm tus kab mob genome los tuav lub xovtooj ntawm tes thiab tus tswv tsev cell lysis thiaj li tso tawm cov kabmob tshiab. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm lub sijhawm latent thiab dab noj hnub. Tsis tas li ntawd, nyob rau hauv kev sib piv, lub sij hawm dab noj hnub khiav rau ib lub sij hawm luv luv. Tab sis, ntawm qhov tsis sib xws, lub sijhawm latent khiav sib piv rau lub sijhawm ntev dua. Yog li, qhov no kuj yog qhov sib txawv tseem ceeb ntawm lub sijhawm latent thiab eclipse.
Tsis tas li ntawd, nyob rau lub sijhawm dab noj hnub, kev tsim cov nucleic acid tshiab thiab phage proteins tshwm sim. Nyob rau hauv lub sij hawm latent, translocation ntawm tus kab mob nucleic acid mus rau hauv cov kab mob cytoplasm los ntawm periplasm, replication ntawm tus kab mob nucleic acids, qhia cov kab mob proteins, ntim cov kab mob, maturation ntawm cov kab mob, cuam tshuam ntawm tus tswv tsev cell membrane thiab tso tawm ntawm tus kab mob. noob neej muaj nqis.
Summary – dab noj hnub vs latent lub sij hawm
A bacteriophage yog tus kab mob uas kis tau thiab rov ua dua hauv cov kab mob. Lub sijhawm latent thiab lub sijhawm dab noj hnub yog ob theem ntawm kev loj hlob bacteriophage. Thaum lub sij hawm eclipse, synthesis ntawm tshiab nucleic acid thiab phage proteins tshwm sim. Eclipse theem yog nested nyob rau hauv lub sij hawm latent. Yog li ntawd, lub sij hawm latent yog lub sij hawm uas pib nrog kev nkag ntawm phage genome mus rau hauv lub host cell thiab terminates ntawm host cell lysis. Yog li, qhov no qhia txog qhov sib txawv ntawm dab noj hnub thiab lub sijhawm latent.
