Qhov Tseem Ceeb Qhov txawv - Alteplase vs Tenecteplase
Myocardial infarction (MI) yog lub xeev Cov hlab plawv tshwm sim vim muaj cov hlab ntsha txhaws. Qhov blockage feem ntau yog tshwm sim los ntawm cov ntshav txhaws uas tsim los ntawm platelet aggregation los ntawm thrombosis. Muaj cov tshuaj sib txawv siv los kho tus mob no uas muaj cov haujlwm thrombolytic. Alteplase thiab Tenecteplas yog ob hom tshuaj siv los kho MI thiab tshem tawm cov ntshav txhaws. Ob qho tshuaj yog cov ntaub so ntswg plasminogen activators. Qhov sib txawv tseem ceeb ntawm Alteplase thiab Tenecteplase yog cov txheej txheem ntawm kev tsim cov tshuaj. Alteplase yog tsim los ntawm glycosylating ib serine protease whereas tenecteplase yog tsim los ntawm complementary DNA (cDNA) kev hloov kho ntawm cov ntaub so ntswg plasminogen activator los ntawm glycosylation ntawm txawv bases.
Alteplase yog dab tsi?
Alteplase, tseem hu ua Tissue plasminogen activator (TPA), yog cov tshuaj pom zoo los ntawm Food and Drug Administration (FDA). Nws qhov hnyav molecular yog nyob ib ncig ntawm 70 kDa. Alteplase yog ib qho serine protease uas yog tsim los ntawm kev hloov cov protein los ntawm glycosylation. Alteplase muaj ob daim ntawv tseem ceeb raws li tus naj npawb ntawm cov chains nws muaj; ob-chain form thiab ib-chain form. Nws Ameslikas muaj nyob rau hauv ib daim ntawv saw, tab sis ib zaug raug rau fibrin nws hloov mus rau nws dimer los yog ob - saw daim ntawv.
Lub tshuab ntawm nws qhov kev txiav txim yog raws li cov cuab yeej ntawm fibrinolysis. Alteplase ib zaug muab tshuaj, khi rau fibrin network ntawm cov hlab ntsha thiab ua kom cov plasminogen tsim ntau plasmin. Plasmin, nyob rau hauv lem, muaj peev xwm ntawm degrading lub fibrin network. Yog li, cov hlab ntsha los yog cov thrombus tsim kuj degraded.
Kev khi ntawm Alteplase rau cov fibrin tshwm sim ntawm Kringle 2 sau thiab tus ntiv tes zoo li tus lej ntawm cov protein fibronectin. Thaum lub plasminogen qhib, Alteplase muaj peev xwm tshem tawm Arginine / Valine daim ntawv cog lus kom degrade plasminogen.
Daim duab 01: Myocardial Infarction
Alteplase feem ntau yog siv los tshem cov ntshav txhaws thaum mob Myocardial infarction thiab lwm lub xeev cov hlab plawv. Tsis tas li ntawd, Alteplase kuj tseem siv los tshem cov ntshav txhaws hauv catheters. Alteplase kuj raug rau cov kev tsis haum tshuaj thiab yog tias nws tau noj ntau dhau, cov txheej txheem ntshav txhaws tuaj yeem cuam tshuam thiab tuaj yeem ua rau los ntshav ntau dhau.
Tenecteplase yog dab tsi?
Tenecteplase kuj yog ib yam tshuaj uas ua raws li cov ntaub so ntswg plasminogen activator thiab tau pom zoo los ntawm FDA. Qhov hnyav molecular ntawm Tenecteplase yog nyob ib ncig ntawm 70kDa. Cov qauv ntawm Tenecteplase yog qhov nyuaj heev. Cov tshuaj genetic engineered protein no tau hloov kho ntawm ntau qhov seem los ntawm glycosylation. Peb cov amino acid hloov pauv thaum lub sij hawm recombination txheej txheem tuaj yeem txheeb xyuas.
- Kev hloov ntawm threonine 103 nrog Asparagine (Thr103Asn)
- Kringle domain 1 - Hloov pauv ntawm Asparagine 117 nrog glutamine (Asn117Gln)
- Protease domain - Tetra alanine hloov pauv
Vim cov no nce qhov polar xwm ntawm cov protein, cov kev hloov kho no ua rau muaj peev xwm ntawm cov tshuaj kom tshem tau cov plasma yooj yim dua thiab yog li ua kom cov tshuaj ruaj khov. Cov kev hloov kho no kuj nce ib nrab-lub neej ntawm cov tshuaj. Txoj kev tseem ceeb ntawm kev tshem tawm yeeb tshuaj tuaj yeem ua tiav ntawm daim siab. Tenecteplase ua rau plasminogen thiab degrade plasminogen los tsim plasmin, uas nyob rau hauv lem yuav pib thrombolytic kev ua ntawm degrading lub thrombus los yog cov ntshav txhaws. Tenecteplase khi ntawm kringle 2 domain thiab cleave ntawm Arginine / valine daim ntawv cog lus kom degrade plasminogen.
Cov tshuaj no yog muab tso rau hauv cov hlab ntsha. Nws tuaj yeem tsim cov kev mob tshwm sim thiab ua rau muaj teeb meem los ntshav. Yog li ntawd, kev noj tshuaj kom raug yog qhov tseem ceeb heev.
Dab tsi zoo sib xws ntawm Alteplase thiab Tenecteplase?
- Ob leeg ua raws li cov ntaub so ntswg plasminogen activators thiab koom nrog hauv fibrinolysis
- Ob qho tshuaj ua rau degrading lub thrombus uas hu ua thrombolysis.
- Ob yam tshuaj yog proteases hloov los ntawm glycosylation.
- Ob cov tshuaj muaj qhov hnyav molecular ze rau 70 kDa.
- Ob lub tshuaj yog muab tso rau hauv cov hlab ntsha.
- Ob cov tshuaj khi ntawm kringle 2 domain ntawm fibrin thiab cleave ntawm Arginine / Valine daim ntawv cog lus.
- Ob qho tshuaj raug tso tawm los ntawm lub siab los ntawm cov txheej txheem detoxification.
- Ob qho tshuaj yuav ua rau muaj teeb meem thiab los ntshav ntau dhau yog tias siv tshuaj tsis raug.
Qhov txawv ntawm Alteplase thiab Tenecteplas yog dab tsi?
Alteplase vs Tenecteplase |
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| Alteplase yog cov ntaub so ntswg plasminogen activator uas yog glycosylated serine protease. | Tenecteplase yog cov ntaub so ntswg plasminogen uas tau hloov kho ntawm glycosylation ntawm peb qhov ua rau muaj kev hloov pauv amino acid. |
| Specificity rau Fibrin | |
| Alteplase muaj qhov sib piv qis rau fibrin dua Tenecteplase. | Tenecteplase muaj qhov tshwj xeeb rau fibrin. |
| Ib nrab neej | |
| Alteplase muaj qhov sib piv tsawg dua ib nrab-lub neej tshaj Tenecteplase. | Tenecteplase muaj ib nrab neej ntev dua. |
Summary – Alteplase vs Tenecteplase
Ob leeg Alteplase thiab Tenecteplase yog cov ntaub so ntswg plasminogen activators uas khi rau lub network fibrin thiab qhib plasminogen degradation. Yog li, ob qho tib si tshuaj yog proteases. Alteplase yog hloov kho los ntawm glycosylation thiab yog serine protease. Tenecteplase tau hloov kho ntawm peb theem los ntawm glycosylation. Ob qho tshuaj no koom nrog hauv kev kho mob myocardial infarction thiab tshem tawm cov ntshav txhaws. Yog li ntawd, ntau dhau ntawm cov tshuaj no tuaj yeem ua rau muaj zog thrombolysis ua rau cov ntshav ntau dhau. Yog li, kev saib xyuas yuav tsum tau noj hauv kev tswj hwm cov tshuaj rau cov neeg mob uas muaj teeb meem ntawm lub plawv tsis zoo. Qhov no yog qhov txawv ntawm Alteplase thiab Tenecteplase.
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Koj tuaj yeem rub tawm PDF version ntawm kab lus no thiab siv nws rau offline lub hom phiaj raws li daim ntawv ceeb toom. Thov download PDF version ntawm no Qhov txawv Ntawm Alteplase thiab Tenecteplase
