Qhov Tseem Ceeb - Hom 1 vs 2 Collagen
Collagen yog cov protein ntau pom nyob rau hauv cov ntaub so ntswg sib txuas, tawv nqaij, pob txha, thiab lwm yam. Nws muab lub zog thiab ruaj khov rau ntau qhov chaw ntawm lub cev. Collagen muaj ib tug complex qauv tsim los ntawm peb polypeptide chains ntim rau hauv triple helix configuration. Muaj ntau hom collagen proteins pom nyob rau hauv lub cev. Ntawm lawv, hom 1, 3 thiab 2 muaj ntau. Hom 1 collagen yog collagen ntau tshaj nyob rau hauv cov tsiaj thiab pom nyob rau hauv daim tawv nqaij, tendons, ligaments, thiab pob txha. Hom 2 yog collagen ntau tshaj plaws hauv pob txha mos. Qhov no yog qhov sib txawv tseem ceeb ntawm hom 1 thiab 2 collagen.
YCollagen yog dab tsi?
Collagen yog ib qho tseem ceeb ntawm cov protein uas pom nyob rau hauv lub extracellular matrix ntawm ntau yam connective cov ntaub so ntswg nyob rau hauv cov tsiaj thiab tib neeg. Nws yog cov protein ntau tshaj plaws nyob rau hauv cov tsiaj. Collagen muaj nyob rau hauv daim ntawv ntawm ntev nyias fibrils uas nyuaj heev thiab insoluble. Nws muaj peb lub polypeptide strands hu ua alpha chains cua ua ke los muab lub triple helix configuration rau collagen. Txhua polypeptide saw muaj nyob ib ncig ntawm 1000 amino acids uas muaj glycine, proline thiab hydroxyproline. Glycine nyob rau hauv txhua peb cov amino acids characterizing repetitive Gly-X-Y kev npaj ntawm cov amino acids nyob rau hauv collagen qauv. X thiab Y feem ntau yog nyob ntawm proline thiab hydroxyproline. Yog li, glycine-proline-hydroxyproline sequences muaj ntau pom nyob rau hauv collagen fibril.
Collagens yog encoded los ntawm gene tsev neeg COL, thiab muaj 45 sib txawv collagen-encoding noob nyob rau hauv tsev neeg no. Muaj kwv yees li kaum rau ntau hom collagen. Ntawm lawv, hom 1, 2 thiab 3 muaj ntau dua. Cov hom no sib txawv nrog kev sib dhos ntawm polypeptide chains, qhov ntev ntawm lub helix, cuam tshuam hauv helix thiab qhov sib txawv ntawm qhov kev txiav ntawm cov helixes, thiab lwm yam.
Collagen synthesis yog cuam tshuam los ntawm Vitamin C vim nws xav tau rau kev tsim cov hydroxyproline amino acids hauv collagen fibril. Collagen ntau lawm txo nrog kev laus. Nws kuj tseem cuam tshuam los ntawm kev raug ultraviolet hluav taws xob thiab qee qhov chaw ib puag ncig. Qee cov kab mob thiab cov kab mob kuj muaj peev xwm degrading collagen thiab cuam tshuam nrog collagen synthesis. Collagen qib raug txo vim kev haus luam yeeb, mob autoimmune, tshav ntuj, noj qab zib ntau, thiab lwm yam.
Daim duab 01: Triple helix qauv ntawm collagen
YYam 1 Collagen yog dab tsi?
Type 1 collagen yog cov collagen ntau tshaj plaws hauv lub cev. Nws suav rau approx. 90% ntawm tag nrho cov collagen nyob rau hauv lub cev. Nws yog dav nyob rau hauv ntau yam ntawm lub cev xws li daim tawv nqaij, leeg, vascular ligature, kab mob, pob txha, thiab lwm yam. Nws yog thawj collagen yam ntxwv vim nws abundance nyob rau hauv lub extracellular matrix thiab yooj yim ntawm kev rho tawm. Nws muaj ob txoj hlua alpha1 thiab ib qho alpha2 saw, txhua tus muaj 1050 tus lej ntawm cov amino acids.
Daim duab 02: Fibrils ntawm collagen hom 1
YYam 2 Collagen yog dab tsi?
Hom 2 collagen yog cov khoom tseem ceeb ntawm cov kab mob extracellular ntawm pob txha mos. Nws suav txog 50% ntawm cov pob txha mos protein. Hom 2 collagen muaj nyob rau hauv cov pob txha mos matrix crosslinked nrog cov proteoglycans. Collagen 2 kuj pom muaj nyob rau hauv cov pob txha vertebral, puab pob ntseg thiab lub vitreous. Collagen 2 yog tsim los ntawm peb pro alpha1 chains. COL2A1 noob yog encoded rau kev qhia ntawm hom 2 collagen nyob rau hauv lub cev. Hom 2 collagen synthesis yog txo nrog lub hnub nyoog thiab tau noj raws li qhov ncauj tshuaj rau kev sib koom tes thiab pob txha mos noj qab haus huv.
Qhov txawv ntawm Hom 1 thiab 2 Collagen yog dab tsi?
Type 1 vs 2 Collagen |
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| Type 1 collagens yog hom collagens ntau tshaj plaws. | Hom 2 collagens yog hom thib peb tshaj plaws ntawm collagen. |
| Nyob hauv lub cev | |
| Lawv muaj ntau tshaj plaws hauv daim tawv nqaij, leeg, vascular ligature, kabmob, thiab pob txha. | Lawv muaj ntau tshaj plaws hauv pob txha mos. |
| Fibrils txoj kab uas hla | |
| Fibrils yog qhov loj dua li hom 2 fibrils. | Fibrils me me dua li cov hom 1. |
| Nature | |
| Cov no tau ntim ib sab ua cov tawv nqaij tuab. | Cov no yog randomly taw qhia nyob rau hauv proteoglycan matrix ntawm pob txha mos. |
| Siv raws li cov khoom ntxiv | |
| Lawv tuaj yeem sib xyaw nrog hom 3 collagen thiab ua tshuaj ntxiv rau daim tawv nqaij, nqaij thiab pob txha | Lawv tuaj yeem noj tau los ua cov tshuaj hauv qhov ncauj rau kev noj qab haus huv ntawm pob txha thiab pob txha. |
| Gene encoded | |
| COL1A1 | COL2A1 |
Summary – Type 1 vs 2 Collagen
Collagen yog cov protein ntau tshaj plaws uas pom hauv lub cev tsiaj txhu, suav txog kwv yees li. 25% ntawm tag nrho cov protein. Nws yog ib qho insoluble fibrous protein uas muab kev yooj yim thiab lub zog rau ntawm daim tawv nqaij, rau tes, cov leeg, pob qij txha thiab pob txha ntawm lub cev. Collagen muaj nyob rau hauv 16 hom sib txawv, thiab feem ntau ntau hom yog hom 1, 2 thiab 3. Collagen triple helix yog tsim los ntawm peb polypeptide chains sequenced nrog Gly-X-Y amino acids rov ua dua. Hom 1 collagen yog hom ntau tshaj plaws nyob rau hauv lub cev thiab pom nyob rau hauv daim tawv nqaij, leeg, vascular ligature, kabmob, thiab pob txha. Hom 2 collagen yog collagen loj hauv pob txha mos.
