Qhov sib txawv tseem ceeb ntawm hom 1 thiab hom 2 alveolar hlwb yog tias hom 1 alveolar hlwb tsis muaj secretory organelles, thaum hom 2 alveolar hlwb muaj secretory organelles.
Alveoli nyob rau hauv cov pa bronchioles ua lub hnab ris thiab nthuav tawm ntawm lawv cov lumen. Cov bronchioles txuas mus rau qhov ntev ntev thiab ua rau cov alveolated nrog cov ceg ntawm alveolar ducts. Cov no yog sib sib zog nqus lined nrog alveoli. Txhua lub raj qhib rau tsib lossis rau rau lub hnab alveolar. Pulmonary alveolus ua rau cov ntaub so ntswg ua haujlwm ntawm lub ntsws ntawm cov tsiaj nyeg. Lub alveolus muaj ib tug yooj yim squamous epithelial txheej thiab ib tug extracellular matrix surrounded los ntawm capillaries. Lub membrane kuj muaj ntau txheej txheej ntawm cov kua dej uas muaj surfactants. Alveolar hlwb muaj peb hom cell, thiab lawv yog hom 1 cell, hom 2 cell, thiab phagocytic cell. Hom 1 alveolar hlwb tseem hu ua hom 1 pneumocytes, thaum hom 2 alveolar hlwb tseem hu ua hom 2 pneumocytes.
Dab tsi yog Hom 1 Alveolar Cells?
Hom 1 alveolar hlwb yog cov kab mob nyuaj nrog ntau yam nyias cytoplasmic daim hlau uas sawv cev rau qhov sib pauv gaseous hauv alveolus. Lawv npog thaj tsam loj ntawm qhov chaw alveolar. Cov hlwb no npog capillaries hauv cov phab ntsa alveolar. Lawv muaj lub hauv paus nucleus thiab loj, nyias cytoplasm. Lub cytoplasm muaj ob peb mitochondria thiab lwm yam organelles ze rau lub hauv paus nucleus. Nyias thiab flattened hom 1 alveolar hlwb yog cov khoom tseem ceeb ntawm cov huab cua-ntshav barrier. Ib hom 1 cell txuas mus rau ntau tshaj ib lub alveolus. Lawv nyob hauv cov pa pauv loj ntawm cov alveolus thiab yog qhov tseem ceeb rau kev saib xyuas ntawm permeability barrier muaj nuj nqi ntawm alveolar membrane.
Cov progenitors ntawm hom 1 alveolar hlwb yog hom 1 pneumocytes, thiab lawv pab tsim cov surfactants thiab homeostasis. Feem ntau siv cov cim hauv kev tshawb pom ntawm hom 1 alveolar hlwb yog podoplanin (T1α) thiab aquaporin5 (Aqua5). Podoplanin yog plasma membrane protein thiab yog cov cim zoo tshaj plaws. Nws tsuas yog qhia nyob rau hauv hom 1 alveolar hlwb hauv lub ntsws. Hom 1 alveolar hlwb kuj muaj caveolae. Caveolae yog cov txheej txheem plasma membrane uas kho cov kev thauj mus los ntawm cov ntaub ntawv thoob plaws hauv lub xovtooj ntawm tes thiab tseem yog cov cim qhia kev sib kho. Claudins yog cov proteins transmembrane uas ua rau muaj kev sib tshuam nruj ntawm alveolar epithelium. Lawv yog cov tseem ceeb tshaj plaws nyob rau hauv hom 1 alveolar hlwb.
Dab tsi yog Hom 2 Alveolar Cells?
Hom 2 alveolar hlwb tseem hu ua tus tiv thaiv ntawm alveoli vim lawv tso cov surfactants, feem ntau txhawm rau ua kom lub alveolar nto tsis muaj kua. Lawv muaj ib tug yooj yim epithelial hauv ob sab phlu, cuboidal nyob rau hauv cov duab, thiab ntau me me. Cov hlwb no muaj nyob rau hauv cov phab ntsa alveolar thiab muaj cov kab mob secretory hu ua lamellar lub cev. Phospholipids khaws cia hauv cov lamellar lub cev. Lawv fuse nrog lub cell membrane thiab pab nyob rau hauv secretion ntawm pulmonary surfactant. Qhov sib txawv ntawm hom 2 hlwb pib ntawm li 24-26 lub lis piam ntawm cev xeeb tub. Cov hlwb sib txawv no tsim cov pulmonary surfactant, uas yog cov tshuaj lipoprotein xav tau rau kev ua haujlwm ntawm lub ntsws los ntawm kev tswj qhov nro ntawm lub alveoli.
Ib txheej kua dej yog tam sim no los pab txhawb kev sib pauv gaseous ntawm cov ntshav thiab alveolar cua, thiab hom 2 hlwb pom nyob rau hauv cov ntshav-cua barrier. Hom 2 hlwb yog qhov tseem ceeb rau kev tswj hwm homeostasis hauv thaj tsam alveolar ntawm lub ntsws. Cov hlwb alveolar no kuj ua haujlwm raws li cov qia hlwb uas muaj peev xwm rov ua dua nws tus kheej thiab sib txawv rau hauv hom 1 hlwb. Hom 2 hlwb kuj muaj peev xwm ntawm cellular faib thiab ua rau ob hom 1 thiab 2 alveolar hlwb thaum lub ntsws puas lawm. Tib neeg cov noob MUC1 ua raws li cov cim hauv kev tshawb pom ntawm hom 2 alveolar hlwb hauv ntsws cancer.
Dab tsi yog qhov zoo sib xws ntawm Hom 1 thiab Hom 2 Alveolar Cells?
- Hom 1 thiab hom 2 alveolar hlwb muaj nyob rau hauv alveolar hlwb.
- Lawv yog kab los ntawm cov kab mob squamous epithelial yooj yim.
- Ob leeg pab txhawb kev zais ntawm pulmonary surfactant.
- Lawv pab hauv homeostasis hauv cheeb tsam alveolar.
- Ob leeg ua raws li cov hlwb progenitor.
Qhov txawv ntawm Hom 1 thiab Hom 2 Alveolar Cells yog dab tsi?
Hom 1 alveolar hlwb tsis muaj cov kab mob zais cia, thaum hom 2 alveolar hlwb muaj cov kab mob secretory. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm hom 1 thiab hom 2 alveolar hlwb. Hom 1 hlwb npog ntau dua 95% ntawm qhov chaw alveolar, thaum hom 2 hlwb nyob ib ncig ntawm 5% ntawm thaj chaw alveolar. Ntxiv mus, hom 1 hlwb yog squamous los yog flattened whereas hom 2 hlwb yog cuboidal nyob rau hauv cov duab.
Cov hauv qab no qhia txog qhov sib txawv ntawm hom 1 thiab hom 2 alveolar hlwb hauv daim ntawv tabular rau kev sib piv ntawm ib sab.
Summary – Hom 1 vs Hom 2 Alveolar Cells
Pulmonary alveolus ua rau cov ntaub so ntswg ua haujlwm ntawm lub ntsws ntawm cov tsiaj. Alveolar hlwb muaj peb hom: hom 1 cell, hom 2 cell, thiab phagocytic cell. Hom 1 alveolar hlwb tsis muaj secretory organelles, thaum hom 2 alveolar hlwb muaj secretory organelles. Hom 1 alveolar hlwb yog cov kab mob nyuaj uas muaj ntau yam nyias cytoplasmic daim hlau uas sawv cev rau qhov sib pauv gaseous hauv lub alveolus. Lawv npog txog 95% ntawm qhov chaw alveolar. Hom 2 alveolar hlwb tseem hu ua cov neeg tiv thaiv ntawm alveoli vim lawv tsuas yog tso cov surfactant kom lub alveolar nto tsis muaj kua. Lawv npog li 5-7% ntawm qhov chaw alveolar. Yog li, qhov no qhia txog qhov sib txawv ntawm hom 1 thiab hom 2 alveolar hlwb.
