Qhov sib txawv tseem ceeb ntawm hematopoietic stem cells thiab progenitor cells yog tias hematopoietic qia hlwb muaj peev xwm sib txawv rau ntau hom hlwb thaum cov hlwb progenitor muaj ntau qhov tshwj xeeb thiab lawv sib txawv rau hauv cov hlwb.
Stem cells muaj peev xwm hloov mus rau ntau hom hlwb thiab loj hlob hauv tib neeg lub cev. Hematopoietic qia hlwb yog cov hlwb tsis paub tab uas tsim rau txhua hom ntshav. Progenitor cells yog cov xeeb leej xeeb ntxwv ntawm cov qia hlwb uas sib txawv ntxiv rau hauv cov cell tshwj xeeb.
Hematopoietic Stem Cells yog dab tsi?
Hematopoietic stem cells (HSCs) yog cov hlwb tsis paub qab hau pom nyob rau hauv cov ntshav peripheral thiab cov pob txha pob txha. Lawv muaj peev xwm ua rau txhua hom qe ntshav, suav nrog cov qe ntshav dawb, qe ntshav liab, thiab platelets. Cov txheej txheem no hu ua hematopoiesis. Thawj HSCs nyob rau hauv vertebrates tshwm sim los ntawm lub ventral endothelial phab ntsa ntawm lub embryonic aorta nyob rau hauv lub aorta-gonad-mesonephros cheeb tsam. Tom qab ntawd, HSCs kuj pom muaj nyob rau hauv lub yolk sac, embryonic lub taub hau, placenta, thiab fetal siab. Cov txheej txheem hematopoiesis hauv cov neeg laus siv qhov chaw hauv cov pob txha liab. Yog li, nyob rau hauv cov neeg laus, HSCs muaj nyob rau hauv cov pob txha pob txha, tshwj xeeb tshaj yog nyob rau hauv lub plab mog, sternum, thiab femur. HSCs loj hlob mus rau ntau hom qe ntshav nyob rau hauv kab hu ua myeloid thiab lymphoid, uas koom nrog hauv dendritic hlwb tsim.
Daim duab 01: Hematopoietic Stem Cells
Myeloid hlwb suav nrog macrophages, monocytes, neutrophils, eosinophils, basophils, thiab megakaryocytes, thiab platelets. Lymphoid hlwb muaj xws li T hlwb, B hlwb, innate lymphoid hlwb, thiab cov hlwb killer ntuj. Cov duab ntawm HSCs feem ntau zoo li lymphocytes. Lawv yog cov puag ncig, tsis ua raws, thiab muaj ib puag ncig nucleus thiab qis cytoplasm rau nucleus piv. HSCs tsis tuaj yeem txheeb xyuas los ntawm lub tshuab tsom iav vim lawv tsis tuaj yeem raug cais tawm raws li cov neeg dawb huv. HSCs raug txheeb xyuas siv cov cytometry ntws. Ntawm no, kev sib xyaw ntawm cov cim ntawm tes sib txawv yog siv los cais cov HSCs tsawg.
Cov Progenitor Cells yog dab tsi?
Progenitor cells yog cov hlwb uas tshwm sim los ntawm cov qia hlwb thiab sib txawv ntxiv los tsim cov cell tshwj xeeb. Progenitor cells muaj peev xwm sib txawv rau hauv cov hlwb uas koom nrog tib cov ntaub so ntswg los yog lub cev ntawm txhua tus progenitor cell. Qee lub hlwb sib txawv rau hauv cov hlwb, thaum lwm lub hlwb muaj peev xwm sib txawv rau ntau tshaj ib hom cell. Progenitor cells yog cov kauj ruam nruab nrab hauv kev loj hlob ntawm cov hlwb hauv cov ntaub so ntswg, kabmob, ntshav, thiab hauv nruab nrab lub paj hlwb. Nyob rau hauv lub hauv paus paj hlwb ntawm tib neeg, muaj peb hom kev sib txawv ntawm cov hlwb hu ua neurons, astrocytes, thiab oligodendrocytes. Cov hlwb no hloov zuj zus los ntawm qhov sib txawv ntawm neural progenitor cells (NPCs).
Daim duab 02: Progenitor Cells
Hematopoietic progenitor cells (HPCs) kuj yog cov nruab nrab hauv kev tsim cov qe ntshav. Hematopoietic qia hlwb sib txawv rau hauv multipotent progenitor cells. Cov hlwb uas muaj zog ntau ntau no sib txawv rau hauv cov kab mob myeloid progenitor (CMP) lossis cov qog ntshav qog ntshav qog ntshav (CLP). Ob leeg CMPs thiab CLPs yog hom oligopotent progenitor hlwb. Cov hlwb no dhau los ua cov qe ntshav uas paub tab nrog cov kab cell. Lub luag haujlwm tseem ceeb ntawm cov hlwb progenitor yog los hloov cov hlwb puas. Yog li ntawd, cov hlwb progenitor yog qhov tsim nyog rau kev kho thiab tswj cov ntaub so ntswg tom qab raug mob. Lawv kuj ua lub luag haujlwm hauv kev loj hlob ntawm embryonic.
Dab tsi zoo sib xws ntawm Hematopoietic Stem Cells thiab Progenitor Cells?
- Ob hom cell muaj nyob hauv ntau cov kab mob.
- Lawv ua lub luag haujlwm hauv kev loj hlob ntawm tes thiab sib txawv.
- Ob lub hlwb muaj kev siv ntau yam hauv kev kho mob ntawm tes xws li kev tsim cov ntaub so ntswg thiab hloov pauv.
- Ob leeg tau rov ua dua.
- Cov hom cell no yog siv rau hauv kev tshawb fawb txog kab lis kev cai ntawm tes los tshuaj xyuas cov lus teb ntawm tes hauv cov chaw kho mob thiab lub cev sib txawv.
Qhov txawv ntawm Hematopoietic Stem Cells thiab Progenitor Cells yog dab tsi?
Hematopoietic qia hlwb muaj peev xwm hloov mus rau ntau hom hlwb thiab loj hlob mus tsis kawg. Lawv tuaj yeem tsim cov ntaub so ntswg tshiab thiab txawm tias tag nrho cov kabmob ntawm ob peb qia hlwb. Ntawm qhov tod tes, cov hlwb progenitor muaj qhov tshwj xeeb tshaj li hematopoietic qia hlwb thiab tuaj yeem sib txawv rau hauv cov hlwb. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm hematopoietic qia hlwb thiab cov hlwb progenitor. Tsis tas li ntawd, raws li lawv rov ua dua li cas, HPSCs qhia qhov kev rov ua tsis tiav thaum lub hlwb progenitor qhia txog tus qauv rov ua dua tshiab.
Cov hauv qab no qhia txog qhov sib txawv ntawm cov qia hlwb hematopoietic thiab cov hlwb progenitor hauv daim ntawv tabular rau ib sab ntawm kev sib piv.
Summary – Hematopoietic Stem Cells vs Progenitor Cells
Hematopoietic qia hlwb yog cov hlwb tsis paub qab hau pom nyob rau hauv cov ntshav peripheral thiab cov pob txha. Lawv muaj peev xwm ua rau txhua hom qe ntshav, xws li cov qe ntshav dawb, qe ntshav liab, thiab platelets, thiab lwm yam., los ntawm cov txheej txheem hu ua hematopoiesis. Progenitor hlwb pib los ntawm qia hlwb, thiab lawv tuaj yeem sib txawv ntxiv los tsim cov cell tshwj xeeb. Lawv muaj peev xwm los sib txawv rau hauv cov hlwb uas koom nrog tib cov ntaub so ntswg los yog lub cev ntawm txhua tus progenitor cell. Ob leeg HSCs thiab progenitor cells muaj kev siv ntau yam kev kho mob ntawm tes xws li cov ntaub so ntswg rov tsim dua thiab hloov pauv. Yog li, qhov no qhia txog qhov sib txawv ntawm hematopoietic stem cells thiab progenitor cells.
