Qhov sib txawv tseem ceeb ntawm theem I thiab theem II metabolism yog tias theem I metabolism hloov cov tshuaj niam txiv mus rau polar active metabolites thaum theem II metabolism hloov cov tshuaj niam txiv mus rau polar inactive metabolites.
Metabolism (tshuaj metabolism) yog cov tshuaj anabolic thiab catabolic tawg los ntawm cov kab mob nyob. Yog li ntawd, tshuaj metabolism yog ib qho tseem ceeb ntawm kev ua neej nyob. Nws tshwm sim los ntawm cov tshuaj tiv thaiv enzymatic. Tsis tas li ntawd, cov tshuaj metabolism yog ntawm peb theem; Theem I (hloov kho), Theem II (conjugation) thiab Theem III (kev hloov kho ntxiv thiab tshem tawm) thiab tag nrho peb theem nquag koom nrog rau detoxify thiab tshem tawm xenobiotics ntawm lub hlwb.
Phase I Metabolism yog dab tsi?
Phase I cov tshuaj tiv thaiv hloov cov tshuaj niam txiv mus rau polar active metabolites los ntawm kev tshem tawm lossis tso rau ntawm pawg polar functional. Yog li ntawd, nyob rau theem I cov tshuaj metabolism, cov tshuaj tiv thaiv tshwm sim los ntawm oxidation (cytochrome p450 monooxygenase system), txo qis (NADPH cytochrome P450 reductase), hydrolysis (esterases), thiab lwm yam.
Ntawm no, ntau yam enzymes reacts los qhia cov polar reactive pawg rau cov substrate (tshuaj). Li no, nws yog theem hu ua kev hloov kho. Qhov kev hloov kho tshaj plaws yog hydroxylation. Nws yog catalyzed los ntawm cytochrome P-450 nyob sib xyaw ua haujlwm oxidase system.
Daim duab 01: Phase I Metabolism
Ntxiv mus, cov tshuaj tiv thaiv oxidation feem ntau thaum lub sijhawm kuv koom nrog kev hloov pauv ntawm C-H daim ntawv cog lus rau hauv C-OH daim ntawv cog lus. Thiab, qhov no yog qhov tseem ceeb vim nws hloov cov tshuaj prodrug (pharmacologically inactive tshuaj) mus rau ib qho tshuaj nquag. Tsis tas li ntawd, theem I metabolism tuaj yeem hloov pauv tsis muaj tshuaj lom molecule mus rau cov tshuaj lom molecule. Txawm li cas los xij, cov tshuaj metabolized los ntawm theem kuv metabolism tau ntev dua ib nrab neej.
Phase II Metabolism yog dab tsi?
Phase II cov tshuaj tiv thaiv hloov cov tshuaj niam txiv mus rau polar inactive metabolites los ntawm kev sib txuas ntawm pawg rau -SH, -OH, -NH2 pab pawg ua haujlwm ntawm cov tshuaj. Yog li, theem II metabolism tshwm sim ntawm methylation (methyltransferase), acetylation (N-acetyltransferase), sulfation (sulphotransferase) thiab glucuronidation (UDP-glucuronosyltransferase)..
Daim duab 02: Phase II Metabolism
Cov metabolites conjugated tau nce molecular hnyav thiab ua haujlwm tsawg dua li cov tshuaj substrate. Yog li ntawd, cov khoom siv metabolic no raug tso tawm hauv lub raum. Cov tib neeg uas tsis muaj peev xwm acetylation raug kev txom nyem ntev los yog tshuaj lom cov lus teb rau cov tshuaj ib txwm siv vim tias cov qib metabolic tsawg.
Dab tsi zoo sib xws ntawm Phase I thiab Phase II Metabolism?
- Ob theem I thiab II metabolism cuam tshuam nrog tshuaj anabolism thiab catabolism.
- Kuj, ob theem tsim cov polar molecules.
- Thiab, lawv tshwm sim hauv kev ua neej nyob.
Qhov txawv ntawm Phase I thiab Phase II Metabolism yog dab tsi?
Phase I thiab theem II metabolism yog ob ntawm peb theem ntawm cov tshuaj metabolism. Phase I metabolism hloov cov tshuaj niam txiv mus rau polar active metabolites thaum theem II metabolism hloov niam txiv mus rau polar inactive metabolites. Yog li, qhov no yog qhov sib txawv tseem ceeb ntawm theem I thiab theem II metabolism. Tsis tas li ntawd, theem I metabolism tshwm sim los ntawm kev tsis tuaj yeem los yog tso rau ntawm pawg polar functional thaum theem II metabolism tshwm sim los ntawm kev sib txuas ntawm pawg sub. Li no, qhov no yog lwm qhov sib txawv ntawm theem I thiab theem II metabolism.
Ntxiv mus, qhov sib txawv ntxiv ntawm theem I thiab theem II metabolism yog tias cov kev cuam tshuam cuam tshuam nrog rau theem I metabolism yog oxidation, txo qis thiab hydrolysis thaum cov tshuaj tiv thaiv cuam tshuam nrog theem II metabolism yog Methylation, glucuronidation, acetylation thiab sulfation.
Cov hauv qab no yog cov ntsiab lus ntxiv ntawm qhov sib txawv ntawm theem I thiab theem II metabolism.
Summary – Phase I vs Phase II Metabolism
Metabolism (tshuaj metabolism) yog cov tshuaj anabolic thiab catabolic tawg los ntawm cov kab mob nyob. Qhov sib txawv tseem ceeb ntawm theem I thiab theem II metabolism yog tias theem I cov tshuaj tiv thaiv hloov cov tshuaj niam txiv mus rau polar active metabolites los ntawm unmasking los yog tso rau ntawm lub ncov qaumteb qabte functional pab pawg neeg thaum lub sij hawm II cov tshuaj hloov ib tug niam txiv tshuaj rau polar inactive metabolites los ntawm conjugation ntawm subgroups rau - SH, -OH thiab -NH2 pab pawg ua haujlwm ntawm cov tshuaj. Tsis tas li ntawd, cov tshuaj metabolized los ntawm theem I metabolism muaj ib nrab-lub neej ntev dua li metabolized los ntawm theem II metabolism.
